3.4.23.B19: plasmepsin V
This is an abbreviated version!
For detailed information about plasmepsin V, go to the full flat file.
Word Map on EC 3.4.23.B19
-
3.4.23.B19
-
plasmepsins
-
plasmodium
-
malaria
-
falciparum
-
erythrocyte
-
pexel
-
antimalarial
-
vacuole
-
aspartyl
-
parasitophorous
-
vivax
-
translocon
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pepstatin
-
asexual
-
toxoplasma
-
hydroxyethylamine
-
peptidomimetics
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phosphatidylinositol-3-phosphate
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cytoadherence
-
exportome
-
picomolar
-
intraerythrocytic
- 3.4.23.B19
-
plasmepsins
- plasmodium
- malaria
- falciparum
- erythrocyte
-
pexel
-
antimalarial
- vacuole
-
aspartyl
-
parasitophorous
- vivax
-
translocon
- pepstatin
-
asexual
- toxoplasma
-
hydroxyethylamine
-
peptidomimetics
- phosphatidylinositol-3-phosphate
-
cytoadherence
-
exportome
-
picomolar
-
intraerythrocytic
Reaction
cleavage of hemoglobin. In contrast to the food vacuole plasmepsins, detergent-solubilized PM V does not bind the aspartic protease inhibitor pepstatin. =
Synonyms
plasmepsin V, Plm V, PlmV, PM V, PMV, PMVm84, PMVp37
ECTree
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IC50 Value
IC50 Value on EC 3.4.23.B19 - plasmepsin V
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0.02225
3-(3-hydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-2,2-dimethylpropyl heptanoate
Plasmodium falciparum
at pH 6.5 and 25°C
0.06894
3-(3-hydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-2,2-dimethylpropyl tridecanoate
Plasmodium falciparum
at pH 6.5 and 25°C
0.05
3-amino-N-[(benzyloxy)carbonyl]-L-phenylalanyl-N-[(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-[(2-phenylethyl)amino]heptan-4-yl]-L-valinamide
Plasmodium falciparum
IC50 above 0.05 mM, at pH 6.4 and 37°C
0.05
4-amino-N-[(benzyloxy)carbonyl]-L-phenylalanyl-N-[(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-[(2-phenylethyl)amino]heptan-4-yl]-L-valinamide
Plasmodium falciparum
IC50 above 0.05 mM, at pH 6.4 and 37°C
0.0856
N'-benzyl-2-(8-methyl-2,4-dioxo-1,3-diazaspiro[4.5]dec-3-yl)-N'-phenylacetohydrazide
Plasmodium falciparum
pH and temperature not specified in the publication
0.05
N-[(benzyloxy)carbonyl]-3-carbamimidamido-L-phenylalanyl-N-[(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-[(2-phenylethyl)amino]heptan-4-yl]-L-valinamide
Plasmodium falciparum
IC50 above 0.05 mM, at pH 6.4 and 37°C
0.05
N-[(benzyloxy)carbonyl]-4-carbamimidamido-L-phenylalanyl-N-[(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-[(2-phenylethyl)amino]heptan-4-yl]-L-valinamide
Plasmodium falciparum
IC50 above 0.05 mM, at pH 6.4 and 37°C
0.00274
N-[(benzyloxy)carbonyl]-O-carbamimidamido-L-homoseryl-N-[(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-[(2-phenylethyl)amino]heptan-4-yl]-L-valinamide
Plasmodium falciparum
at pH 6.4 and 37°C
0.000128
N2-[(benzyloxy)carbonyl]-L-arginyl-N-[(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-[(2-phenylethyl)amino]heptan-4-yl]-L-valinamide
Plasmodium falciparum
at pH 6.4 and 37°C
0.0416
N2-[(benzyloxy)carbonyl]-N-carbamimidoyl-L-glutaminyl-N-[(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-[(2-phenylethyl)amino]heptan-4-yl]-L-valinamide
Plasmodium falciparum
at pH 6.4 and 37°C
0.05
N2-[(benzyloxy)carbonyl]-N5-(methylsulfonyl)-L-ornithyl-N-[(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-[(2-phenylethyl)amino]heptan-4-yl]-L-valinamide
Plasmodium falciparum
IC50 above 0.05 mM, at pH 6.4 and 37°C
0.05
N2-[(benzyloxy)carbonyl]-N5-(N-cyanocarbamimidoyl)-L-ornithyl-N-[(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-[(2-phenylethyl)amino]heptan-4-yl]-L-valinamide
Plasmodium falciparum
IC50 above 0.05 mM, at pH 6.4 and 37°C
0.00388
N2-[(benzyloxy)carbonyl]-N5-(N-hydroxycarbamimidoyl)-L-ornithyl-N-[(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-[(2-phenylethyl)amino]heptan-4-yl]-L-valinamide
Plasmodium falciparum
at pH 6.4 and 37°C
0.18
N2-[(benzyloxy)carbonyl]-N5-(N-methoxycarbamimidoyl)-L-ornithyl-N-[(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-[(2-phenylethyl)amino]heptan-4-yl]-L-valinamide
Plasmodium falciparum
at pH 6.4 and 37°C
0.0377
N2-[(benzyloxy)carbonyl]-N5-(N-methylcarbamimidoyl)-L-ornithyl-N-[(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-[(2-phenylethyl)amino]heptan-4-yl]-L-valinamide
Plasmodium falciparum
at pH 6.4 and 37°C
0.05
N2-[(benzyloxy)carbonyl]-N5-(N-nitrocarbamimidoyl)-L-ornithyl-N-[(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-[(2-phenylethyl)amino]heptan-4-yl]-L-valinamide
Plasmodium falciparum
IC50 above 0.05 mM, at pH 6.4 and 37°C
0.05
N2-[(benzyloxy)carbonyl]-N5-(propan-2-yl)-L-ornithyl-N-[(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-[(2-phenylethyl)amino]heptan-4-yl]-L-valinamide
Plasmodium falciparum
IC50 above 0.05 mM, at pH 6.4 and 37°C
0.05
N2-[(benzyloxy)carbonyl]-N5-carbamimidoyl-N5-methyl-L-ornithyl-N-[(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-[(2-phenylethyl)amino]heptan-4-yl]-L-valinamide
Plasmodium falciparum
IC50 above 0.05 mM, at pH 6.4 and 37°C
0.05
N2-[(benzyloxy)carbonyl]-N5-carbamoyl-L-ornithyl-N-[(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-[(2-phenylethyl)amino]heptan-4-yl]-L-valinamide
Plasmodium falciparum
at pH 6.4 and 37°C
0.0403
N2-[(benzyloxy)carbonyl]-N5-ethanimidoyl-L-ornithyl-N-[(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-[(2-phenylethyl)amino]heptan-4-yl]-L-valinamide
Plasmodium falciparum
at pH 6.4 and 37°C
0.05
N5-acetyl-N2-[(benzyloxy)carbonyl]-L-ornithyl-N-[(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-[(2-phenylethyl)amino]heptan-4-yl]-L-valinamide
Plasmodium falciparum
IC50 above 0.05 mM, at pH 6.4 and 37°C
0.0487
tert-butyl (3-[[(2-methyl-1H-indol-3-yl)carbonyl]amino]propyl)(pyridin-3-ylmethyl)carbamate
Plasmodium falciparum
pH and temperature not specified in the publication
0.00001
WEHI-842
Plasmodium falciparum
pH and temperature not specified in the publication