Literature summary for 3.4.23.B19 extracted from

Meissner, K.A.; Kronenberger, T.; Maltarollo, V.G.; Trossini, G.H.G.; Wrenger, C.
Targeting the Plasmodium falciparum plasmepsin V by ligand-based virtual screening (2019), Chem. Biol. Drug Des., 93, 300-312 .

Search for more literature for 3.4.23.B19

Inhibitors

Inhibitors	Comment	Organism	Structure
lopinavir	-	Plasmodium falciparum
N'-benzyl-2-(8-methyl-2,4-dioxo-1,3-diazaspiro[4.5]dec-3-yl)-N'-phenylacetohydrazide	ZINC36767691	Plasmodium falciparum
N,N'-(propane-1,3-diyl)bis(2-bromobenzamide)	ZINC02802008	Plasmodium falciparum
N-(2-[[(2-fluorophenyl)methyl]amino]-2-oxoethyl)-2-iodobenzamide	ZINC07922110	Plasmodium falciparum
nelfinavir	-	Plasmodium falciparum
ritonavir	-	Plasmodium falciparum
saquinavir	-	Plasmodium falciparum
tert-butyl (3-[[(2-methyl-1H-indol-3-yl)carbonyl]amino]propyl)(pyridin-3-ylmethyl)carbamate	ZINC72012008	Plasmodium falciparum
WEHI-842	-	Plasmodium falciparum
WEHI-916	-	Plasmodium falciparum

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	Q8I6Z5	isolate 3D7	-

Synonyms

Synonyms	Comment	Organism
PMV	-	Plasmodium falciparum

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0487	-	pH and temperature not specified in the publication	Plasmodium falciparum	tert-butyl (3-[[(2-methyl-1H-indol-3-yl)carbonyl]amino]propyl)(pyridin-3-ylmethyl)carbamate
0.0856	-	pH and temperature not specified in the publication	Plasmodium falciparum	N'-benzyl-2-(8-methyl-2,4-dioxo-1,3-diazaspiro[4.5]dec-3-yl)-N'-phenylacetohydrazide

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Release 2023.1 (January 2023)