3.4.23.B19: plasmepsin V
This is an abbreviated version!
For detailed information about plasmepsin V, go to the full flat file.
Word Map on EC 3.4.23.B19
-
3.4.23.B19
-
plasmepsins
-
plasmodium
-
malaria
-
falciparum
-
erythrocyte
-
pexel
-
antimalarial
-
vacuole
-
aspartyl
-
parasitophorous
-
vivax
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translocon
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pepstatin
-
asexual
-
toxoplasma
-
hydroxyethylamine
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peptidomimetics
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phosphatidylinositol-3-phosphate
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cytoadherence
-
exportome
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picomolar
-
intraerythrocytic
- 3.4.23.B19
-
plasmepsins
- plasmodium
- malaria
- falciparum
- erythrocyte
-
pexel
-
antimalarial
- vacuole
-
aspartyl
-
parasitophorous
- vivax
-
translocon
- pepstatin
-
asexual
- toxoplasma
-
hydroxyethylamine
-
peptidomimetics
- phosphatidylinositol-3-phosphate
-
cytoadherence
-
exportome
-
picomolar
-
intraerythrocytic
Reaction
cleavage of hemoglobin. In contrast to the food vacuole plasmepsins, detergent-solubilized PM V does not bind the aspartic protease inhibitor pepstatin. =
Synonyms
plasmepsin V, Plm V, PlmV, PM V, PMV, PMVm84, PMVp37
ECTree
3.4.23.B19 plasmepsin VAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.4.23.B19 - plasmepsin V
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
DABCYL-LNKRLLHETQ-EDANS + H2O
?
-
fluorogenic peptide corresponding to the PEXEL motif for histidine-rich protein II is cleaved by PM V. Mutation of P1 Leu or P3 Arg abolishes cleavage
-
-
?
Dabcyl-LNKRLLVETQE-Edans + H2O
?
about 150% activity compared to the HRPII peptide Dabcyl-LNKRLLHETQE-Edans
-
-
?
Dabcyl-RYVRELSETE-Edans + H2O
?
about 68% activity compared to the EMP2 peptide Dabcyl-RYVRILSETE-Edans
-
-
?
Dabcyl-RYVRELSETEE-Edans + H2O
?
about 10-25% activity compared to the EMP2 peptide Dabcyl-RYVRILSETEE-Edans
-
-
?
Dabcyl-RYVRILEETE-Edans + H2O
?
about 28% activity compared to the EMP2 peptide Dabcyl-RYVRILSETE-Edans
-
-
?
Dabcyl-RYVRILEETEE-Edans + H2O
?
about 7-30% activity compared to the EMP2 peptide Dabcyl-RYVRILSETEE-Edans
-
-
?
DABCYL-RYVRILSETE-EDANS + H2O
?
-
fluorogenic peptide corresponding to the PEXEL motif for PfEMP2 is cleaved by PM V. Mutation of P1 Leu or P3 Arg abolishes cleavage
-
-
?
Dabcyl-RYVRILVETE-Edans + H2O
?
about 28% activity compared to the EMP2 peptide Dabcyl-RYVRILSETE-Edans
-
-
?
Dabcyl-RYVRILVETEE-Edans + H2O
?
about 8-30% activity compared to the EMP2 peptide Dabcyl-RYVRILSETEE-Edans
-
-
?
Dabcyl-RYVRKLSETE-Edans + H2O
?
about 70% activity compared to the EMP2 peptide Dabcyl-RYVRILSETE-Edans
-
-
?
Dabcyl-RYVRKLSETEE-Edans + H2O
?
about 70% activity compared to the EMP2 peptide Dabcyl-RYVRILSETEE-Edans
-
-
?
EMP2 + H2O
Dabcyl-RYVRIL + SETE-Edans
i.e. Dabcyl-RYVRILSETE-Edans
-
-
?
erythrocyte membrane protein 2 + H2O
?
i.e. Dabcyl-RYVRILSETEE-Edans
-
-
?
histidine-rich protein II + H2O
?
i.e. Dabcyl-LNKRLLHETQE-Edans
-
-
?
Dabcyl-LNKRELHETQE-Edans + H2O
?
about 50% activity compared to the HRPII peptide Dabcyl-LNKRLLHETQE-Edans
-
-
?
Dabcyl-LNKRELHETQE-Edans + H2O
?
Plasmodium vivax Thai
about 50% activity compared to the HRPII peptide Dabcyl-LNKRLLHETQE-Edans
-
-
?
Dabcyl-LNKRKLHETQE-Edans + H2O
?
about 130% activity compared to the HRPII peptide Dabcyl-LNKRLLHETQE-Edans
-
-
?
Dabcyl-LNKRKLHETQE-Edans + H2O
?
Plasmodium vivax Thai
about 130% activity compared to the HRPII peptide Dabcyl-LNKRLLHETQE-Edans
-
-
?
Dabcyl-LNKRLLEETQE-Edans + H2O
?
about 50% activity compared to the HRPII peptide Dabcyl-LNKRLLHETQE-Edans
-
-
?
Dabcyl-LNKRLLEETQE-Edans + H2O
?
Plasmodium vivax Thai
about 50% activity compared to the HRPII peptide Dabcyl-LNKRLLHETQE-Edans
-
-
?
Dabcyl-LNKRLLSETQE-Edans + H2O
?
about 180% activity compared to the HRPII peptide Dabcyl-LNKRLLHETQE-Edans
-
-
?
Dabcyl-LNKRLLSETQE-Edans + H2O
?
Plasmodium vivax Thai
about 180% activity compared to the HRPII peptide Dabcyl-LNKRLLHETQE-Edans
-
-
?
EMP2 + H2O
?
i.e. Dabcyl-RYVRILSETE-Edans, most efficient substrate. Replacing Ser by Val or Glu of the PfEMP2 peptide P1' position markedly reduces the enzyme activity of the enzyme
-
-
?
HRPII + H2O
?
i.e. Dabcyl-LNKRLLHETQE-Edans. Replacing His by Val or Ser of the HRPII peptide P1' position increases the cleavage activity
-
-
?
additional information
?
-
-
PM V pull-downs identified an ER-resident HSP70 and HSP101 as associated proteins
-
-
?
additional information
?
-
-
plasmepsin V recognizes pentameric motif RxLxE/Q/D of exported proteins. Plasmepsin V cleavage reveals the export signal xE/Q/D at the N-terminus of cargo proteins. Plasmepsin V activity is essential and linked with other key export events
-
-
?
additional information
?
-
no activity with DABCYL-KAVHYLEHNVKE-EDANS and Dabcyl-RYVAIASATEE-Edans
-
-
?
additional information
?
-
-
no activity with DABCYL-KAVHYLEHNVKE-EDANS and Dabcyl-RYVAIASATEE-Edans
-
-
?
additional information
?
-
no activity with DABCYL-KAVHYLEHNVKE-EDANS and Dabcyl-RYVAIASATEE-Edans
-
-
?
additional information
?
-
-
no activity with DABCYL-KAVHYLEHNVKE-EDANS and Dabcyl-RYVAIASATEE-Edans
-
-
?
additional information
?
-
Plasmodium vivax Thai
no activity with DABCYL-KAVHYLEHNVKE-EDANS and Dabcyl-RYVAIASATEE-Edans
-
-
?
