3.4.23.B11: spumapepsin

This is an abbreviated version!
For detailed information about spumapepsin, go to the full flat file.

Reaction

Good cleavage at the peptide bonds: Asn-Thr, Asn-Gln, Asn-Cys and Asn-Ala =

Synonyms

core polyprotein, Gag polyprotein, HFV PR, HSRV protease, human foamy virus protease, human foamy virus protease PR, human foamy virus proteinase, More, spumapepsin

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.B11 spumapepsin

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Results	in table
2	Activating Compound
3	AA Sequence
1	CAS Registry Number
8	Cloned(Commentary)
2	General Information
2	General Stability
3	IC50 Value
3	Inhibitors
12	KM Value [mM]
5	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
20	Organism
9	pH Optimum
2	pH Range
1	pH Stability
8	Protein Variants
3	Purification (Commentary)
1	Reaction
20	Reference
1	Renatured (Commentary)
2	Specific Activity [micromol/min/mg]
39	Substrates and Products (Substrate)
11	Subunits
21	Synonyms
2	Temperature Optimum [°C]
10	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.4.23.B11 - spumapepsin

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

Gag protein precursor + H2O

?

2 entries

Pol protein precursor + H2O

?

Human spumaretrovirus

-

-

668801

-

-

?

pr74 + H2O

?

2 entries

additional information

?

-

2 entries

Gag protein precursor + H2O

?

Human spumaretrovirus

P14349

-

683834

-

-

?

Gag protein precursor + H2O

?

Human spumaretrovirus

-

-

668801

-

-

?

pr74 + H2O

?

Human spumaretrovirus

-

the cleavage site that leads to the formation of the HFV gag proteins p70 and p3 is located 27 amino acid residues upstream of the carboxy terminus of the p74 gag precursor

647789

-

-

?

pr74 + H2O

?

Human spumaretrovirus

-

Pr74 is the gag precursor protein with a molecular mass of 74000 Da from which a 70000 Da protein, p70, is cleaved by the viral protease. Carboxy-terminal cleavage of the human foamy virus Gag precursor molecule is an essential step in the viral life cycle, absolute requirement for viral infectivity

647787

-

-

?

additional information

?

-

Human spumaretrovirus

-

the enzyme is essential for infectivity but not for formation of the 120000 Da Pol polyprotein

647788

-

-

?

additional information

?

-

Human spumaretrovirus

-

spumaretroviruses produce separate Pol and Gag precursor proteins from spliced mRNA in contrast to other retroviruses

668801

-

-

?