3.4.23.B11: spumapepsin
This is an abbreviated version!
For detailed information about spumapepsin, go to the full flat file.
Word Map on EC 3.4.23.B11
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3.4.23.B11
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polyproteins
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leukemia
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envelope
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thymocytes
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retroviral
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virion
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spumaretrovirus
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viruses
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antisera
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sarcoma
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nonviral
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maltose
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preleukemic
- 3.4.23.B11
- polyproteins
- leukemia
- envelope
-
thymocytes
-
retroviral
- virion
- spumaretrovirus
- viruses
- antisera
- sarcoma
-
nonviral
- maltose
-
preleukemic
Reaction
Good cleavage at the peptide bonds: Asn-Thr, Asn-Gln, Asn-Cys and Asn-Ala =
Synonyms
core polyprotein, Gag polyprotein, HFV PR, HSRV protease, human foamy virus protease, human foamy virus protease PR, human foamy virus proteinase, More, spumapepsin
ECTree
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General Information
General Information on EC 3.4.23.B11 - spumapepsin
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physiological function
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the RNase H domain is essential for protease activity, but can functionally be substituted by RNase H domains of other retroviruses.The RNase H domain might be involved in the stabilization of the protease dimer, while the reverse transcriptase domain is essential for RNA dependent protease activation
additional information
the Pro-Pol polyprotein elements A and B are required for protease dimerization and activation, while the C-element is required for pol expression and splicing regulation