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3.4.23.B11: spumapepsin

This is an abbreviated version!
For detailed information about spumapepsin, go to the full flat file.

Word Map on EC 3.4.23.B11

Reaction

Good cleavage at the peptide bonds: Asn-Thr, Asn-Gln, Asn-Cys and Asn-Ala =

Synonyms

core polyprotein, Gag polyprotein, HFV PR, HSRV protease, human foamy virus protease, human foamy virus protease PR, human foamy virus proteinase, More, spumapepsin

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.B11 spumapepsin

General Information

General Information on EC 3.4.23.B11 - spumapepsin

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
-
the RNase H domain is essential for protease activity, but can functionally be substituted by RNase H domains of other retroviruses.The RNase H domain might be involved in the stabilization of the protease dimer, while the reverse transcriptase domain is essential for RNA dependent protease activation
additional information
the Pro-Pol polyprotein elements A and B are required for protease dimerization and activation, while the C-element is required for pol expression and splicing regulation