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Literature summary for 3.4.23.B11 extracted from
- Spumapepsins (2004), Handbook of Proteolytic Enzymes (Barrett, J. ; Rawlings, N. D. ; Woessner, J. F. , eds. ), 1, 188-190.
No PubMed abstract available
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression as His6-tagged enzyme in Escherichia coli | Human spumaretrovirus |
General Stability
| General Stability | Organism |
|---|---|
| the dimeric enzyme is quite unstable compared to the enzyme of other species | Human spumaretrovirus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics with synthetic peptide substrates | Human spumaretrovirus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 10000 | - |
2 * 10000, SDS-PAGE | Human spumaretrovirus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Gag protein precursor + H2O | Human spumaretrovirus | - |
? | - |
? |  |
| additional information | Human spumaretrovirus | spumaretroviruses produce separate Pol and Gag precursor proteins from spliced mRNA in contrast to other retroviruses | ? | - |
? | |
| Pol protein precursor + H2O | Human spumaretrovirus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Human spumaretrovirus | - |
HSV, i.e. Human foamy virus HFV | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Gag protein precursor + H2O | - |
Human spumaretrovirus | ? | - |
? | |
| additional information | spumaretroviruses produce separate Pol and Gag precursor proteins from spliced mRNA in contrast to other retroviruses | Human spumaretrovirus | ? | - |
? | |
| Pol protein precursor + H2O | - |
Human spumaretrovirus | ? | - |
? | |
| PRAVNTVTQR + H2O | analysis of cleavage sites and kinetics with synthetic peptide substrates | Human spumaretrovirus | PRAVN + TVTQR | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 10000, SDS-PAGE | Human spumaretrovirus |
| More | the subunits contain an Gly-Arg-Lys motif of aspartic acid proteases | Human spumaretrovirus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | the enzyme belongs to the A9 peptidase family | Human spumaretrovirus |
| More | the enzyme belongs to the A9 peptidase family | Bovine foamy virus |
| More | the enzyme belongs to the A9 peptidase family | Equine foamy virus |
| More | the enzyme belongs to the A9 peptidase family | Feline foamy virus |
| More | the enzyme belongs to the A9 peptidase family | Simian foamy virus |
| spumapepsin | - |
Human spumaretrovirus |
| spumapepsin | - |
Bovine foamy virus |
| spumapepsin | - |
Equine foamy virus |
| spumapepsin | - |
Feline foamy virus |
| spumapepsin | - |
Simian foamy virus |
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