3.4.23.B11: spumapepsin

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For detailed information about spumapepsin, go to the full flat file.

Reaction

Good cleavage at the peptide bonds: Asn-Thr, Asn-Gln, Asn-Cys and Asn-Ala =

Synonyms

core polyprotein, Gag polyprotein, HFV PR, HSRV protease, human foamy virus protease, human foamy virus protease PR, human foamy virus proteinase, More, spumapepsin

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.B11 spumapepsin

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Results	in table
2	Activating Compound
3	AA Sequence
1	CAS Registry Number
8	Cloned(Commentary)
2	General Information
2	General Stability
3	IC50 Value
3	Inhibitors
12	KM Value [mM]
5	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
20	Organism
9	pH Optimum
2	pH Range
1	pH Stability
8	Protein Variants
3	Purification (Commentary)
1	Reaction
20	Reference
1	Renatured (Commentary)
2	Specific Activity [micromol/min/mg]
39	Substrates and Products (Substrate)
11	Subunits
21	Synonyms
2	Temperature Optimum [°C]
10	Turnover Number [1/s]

pH Optimum

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pH Optimum on EC 3.4.23.B11 - spumapepsin

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pH OPTIMUM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

6

Human spumaretrovirus

-

-

670143

6.21

Human spumaretrovirus

-

Q8R mutant

684018

6.24

Human spumaretrovirus

-

H22L mutant

684018

6.3

Human spumaretrovirus

-

wild-type

684018

6.5

Human spumaretrovirus

-

H22L/T28D double mutant, increased pH optimum identified

684018

6.5 - 9

Human spumaretrovirus

-

Q8R/T28D double mutant, increased pH optimum identified

684018

6.6

Human spumaretrovirus

-

-

647784

6.65

Human spumaretrovirus

-

S25T mutant, increased pH optimum identified

684018

6.81

Human spumaretrovirus

-

T28D mutant, increased pH optimum identified

684018