3.4.23.B11: spumapepsin
This is an abbreviated version!
For detailed information about spumapepsin, go to the full flat file.
Word Map on EC 3.4.23.B11
-
3.4.23.B11
-
polyproteins
-
leukemia
-
envelope
-
thymocytes
-
retroviral
-
virion
-
spumaretrovirus
-
viruses
-
antisera
-
sarcoma
-
nonviral
-
maltose
-
preleukemic
- 3.4.23.B11
- polyproteins
- leukemia
- envelope
-
thymocytes
-
retroviral
- virion
- spumaretrovirus
- viruses
- antisera
- sarcoma
-
nonviral
- maltose
-
preleukemic
Reaction
Good cleavage at the peptide bonds: Asn-Thr, Asn-Gln, Asn-Cys and Asn-Ala =
Synonyms
core polyprotein, Gag polyprotein, HFV PR, HSRV protease, human foamy virus protease, human foamy virus protease PR, human foamy virus proteinase, More, spumapepsin
ECTree
Advanced search results
Engineering
Engineering on EC 3.4.23.B11 - spumapepsin
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
additional information
PCR mutagenesis, cleavage site mutants of Human foamy virus protease PR generated using the full-length viral clone pcHFV13
additional information
-
a Pol mutant lacking the integrase domain has defects in protease activity and Pol packaging into virions. Introduction of a leucine zipper dimerization motif, zip, in an integrase truncation mutant can restore protease activity, leading to Pol processing in cells. However, these zip mutants neither cleave Gag nor incorporate Pol into virions. The integrase domain may be required for Pol dimerization, which is necessary for the creation of a functional protease active site