3.4.23.B11: spumapepsin

This is an abbreviated version!
For detailed information about spumapepsin, go to the full flat file.

Word Map on EC 3.4.23.B11

3.4.23.B11

polyproteins

leukemia

envelope

thymocytes

retroviral

virion

spumaretrovirus

viruses

antisera

sarcoma

nonviral

maltose

preleukemic

Reaction

Good cleavage at the peptide bonds: Asn-Thr, Asn-Gln, Asn-Cys and Asn-Ala =

Synonyms

core polyprotein, Gag polyprotein, HFV PR, HSRV protease, human foamy virus protease, human foamy virus protease PR, human foamy virus proteinase, More, spumapepsin

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.23 Aspartic endopeptidases

3.4.23.B11 spumapepsin

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2	Activating Compound
3	AA Sequence
1	CAS Registry Number
8	Cloned(Commentary)
2	General Information
2	General Stability
3	IC50 Value
3	Inhibitors
12	KM Value [mM]
5	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
20	Organism
9	pH Optimum
2	pH Range
1	pH Stability
8	Protein Variants
3	Purification (Commentary)
1	Reaction
20	Reference
1	Renatured (Commentary)
2	Specific Activity [micromol/min/mg]
39	Substrates and Products (Substrate)
11	Subunits
21	Synonyms
2	Temperature Optimum [°C]
10	Turnover Number [1/s]

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Cloned on EC 3.4.23.B11 - spumapepsin

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expressed in Escherichia coli, wild-type and mutant enzymes, in fusion with maltose binding protein

Human spumaretrovirus

684018

expression as His6-tagged enzyme in Escherichia coli

Human spumaretrovirus

668801

expression in Escherichia coli

2 entries

expression of a 141 residue long part of the HFV as a fusion protein with maltose binding protein in Escherichia coli

Human spumaretrovirus

647784

gene pol encoding the Pro-Pol polyprotein which includes the enzyme subunits, expression regulation and splicing, overview. The foamy viral purine-rich C element, also encoded by gene pol, regulates splicing by suppressing the branch point recognition of the strongest env splice acceptor. It is essential for the formation of unspliced gag and singly spliced pol transcripts

human foamy virus

P14350

755371

the enzyme is cloned into a modified thioredoxin fusion vector that carries a His-tag in the centrally located surface loop of the Escherichia coli trxA protein, bacterially expressed as a soluble fusion protein

Human spumaretrovirus

647789

Virion-associated RT assay is performed in BHK cells, ATCC CCL-10. Analysis of titers of wild-type and mutant proviruses transiently transfected into HEK-293T cells. Titers of Pol cleavage site mutants after infection measured in HEL cells.

Human spumaretrovirus

P14349

683834