3.4.22.B79: nsP2 protease

This is an abbreviated version!
For detailed information about nsP2 protease, go to the full flat file.

Word Map on EC 3.4.22.B79

3.4.22.B79

polyproteins

viruses

alphavirus

chikungunya

replicase

sindbis

chikv

nsp1

semliki

subgenomic

positive-stranded

venezuelan

hp-prrsv

papain-like

noncytopathic

plus-stranded

positive-sense

minus-strand

analysis

3c-like

drug development

autoprotease

medicine

Reaction

the enzymes processes the alphavirus nonstructural polyprotein (nsP1234). The enzyme from Venezuelan equine encephalitis virus shwos a preferens for Gly or Als in position P1', Ala or Cys in P1, and Gly in P2 =

Synonyms

non-structural polyprotein 2, nonstructural polyprotein, nonstructural protein, nonstructural protein 2, ns polyprotein, nsP2, nsP2 protease, nsp2 protein, nsp2pro, p39 nsp2 protease

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.22 Cysteine endopeptidases

3.4.22.B79 nsP2 protease

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Results	in table
2	Activating Compound
11	AA Sequence
12	Application
13	Cloned(Commentary)
10	Crystallization (Commentary)
9	General Information
18	Inhibitors
23	kcat/KM [mM/s]
35	KM Value [mM]
3	Localization
3	Metals/Ions
2	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
51	Organism
1	pH Optimum
2	pH Range
2	Posttranslational Modification
81	Protein Variants
6	Purification (Commentary)
1	Reaction
45	Reference
1	Storage Stability
37	Substrates and Products (Substrate)
4	Subunits
24	Synonyms
3	Temperature Optimum [°C]
2	Temperature Range [°C]
3	Temperature Stability [°C]
30	Turnover Number [1/s]

Organism

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Organism on EC 3.4.22.B79 - nsP2 protease

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Chikungunya virus

8 entries

Chikungunya virus 899

truncated non-structural polyprotein

753234

C8YZ72

UniProt

Chikungunya virus ECSA

nonstructural polyprotein

755448

Q1W368

UniProt

Chikungunya virus ECSA E1:226V

755412

Chikungunya virus S27

732352, 732353

Q8JUX6

UniProt

Chikungunya virus S27-African prototype

753238, 753844

Q8JUX6

UniProt

infectious bronchitis virus

706978

Murine coronavirus

replicase polyprotein

754547

P0C6X9

UniProt

Murine coronavirus A59

replicase polyprotein

754547

P0C6X9

UniProt

porcine reproductive and respiratory syndrome virus

Venezuelan equine encephalitis virus

5 entries

Venezuelan equine encephalitis virus Mena II

755648

Q9WJC7

UniProt

Venezuelan equine encephalitis virus Trinidad donkey

2 entries