3.4.22.B79: nsP2 protease

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For detailed information about nsP2 protease, go to the full flat file.

Reaction

the enzymes processes the alphavirus nonstructural polyprotein (nsP1234). The enzyme from Venezuelan equine encephalitis virus shwos a preferens for Gly or Als in position P1', Ala or Cys in P1, and Gly in P2 =

Synonyms

non-structural polyprotein 2, nonstructural polyprotein, nonstructural protein, nonstructural protein 2, ns polyprotein, nsP2, nsP2 protease, nsp2 protein, nsp2pro, p39 nsp2 protease

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B79 nsP2 protease

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Results	in table
2	Activating Compound
11	AA Sequence
12	Application
13	Cloned(Commentary)
10	Crystallization (Commentary)
9	General Information
18	Inhibitors
23	kcat/KM [mM/s]
35	KM Value [mM]
3	Localization
3	Metals/Ions
2	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
51	Organism
1	pH Optimum
2	pH Range
2	Posttranslational Modification
81	Protein Variants
6	Purification (Commentary)
1	Reaction
45	Reference
1	Storage Stability
37	Substrates and Products (Substrate)
4	Subunits
24	Synonyms
3	Temperature Optimum [°C]
2	Temperature Range [°C]
3	Temperature Stability [°C]
30	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.4.22.B79 - nsP2 protease

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

XJ-160 virus-specific protein + H2O

?

Sindbis virus

-

-

710679

-

-

?

additional information

?

-

Sindbis virus

-

enzyme is critically involved in development of cytopathic effect. Cytotoxic effect of enzyme is due to its ability to cause transcriptional shutoff

666194

-

-

?