3.4.22.B6: cathepsin B-like protease
This is an abbreviated version!
For detailed information about cathepsin B-like protease, go to the full flat file.
Reaction
the enzyme does not readily hyrolyze benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin (which is cleaved by cathespsin B). The enzyme is not able to cleave synthetic substrates having an Arg in position P2
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Synonyms
AC-5 cathepsin B-like protease, CatB, CatB2, CathB-1, CathB2, CathB3, cathepsin B type protease, cathepsin B-like cysteine protease, cathepsin B-like cysteine protease 1, cathepsin B-like cysteine protease 2, cathepsin B-like cysteine proteinase, cathepsin B-like cysteine proteinase 1, cathepsin B-like cysteine proteinase 2, cathepsin B-like peptidase, cathepsin B-like protease, CBc1, CBc6, CBL1, CmCatB, CmCatB1, CmCatB2, CPB, CPC, CPC protease, eimeripain, HCB, LmacatB, LOC103512321, More, TbCatB, TcoCBc1, TcoCBc6, TrCB2
ECTree
General Information
General Information on EC 3.4.22.B6 - cathepsin B-like protease
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malfunction
inhibition of the lysosomal cathepsin B-like protease blocks endocytosis causing cell death. Nicotinamide causes cytokinesis defects and cell cycle arrest at G2 phase
evolution
the enzyme is classified as a papain-like protease with similar characteristics to toxopain-1 from the related apicomplexan parasite, Toxoplasma gondii
evolution
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the enzyme is related to other cathepsin B family members with the conserved catalytic triad (Cys, His, Asn) and diagnostic occluding loop
physiological function
cathepsin B-like is a lysosomal protease responsible for degradation of host-derived growth factors, such as transferrin, in the bloodstream form of Trypanosoma brucei
physiological function
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the mature enzyme is an excretory/secretory product of of L4 larval stage of Angiostrongylus cantonensis, excretory-secretory antigens are involved in parasite-host interactions
physiological function
both isoforms CathB2 and CathB3 are capable of acting as endopeptidases and exopeptidases, releasing dipeptides from the C-termini of substrates
physiological function
bth isoforms CathB2 and CathB3 are capable of acting as endopeptidases and exopeptidases, releasing dipeptides from the C-termini of substrates
physiological function
the inhibition of CathB-1 enzymatic activity with antiserum partly suppresses larval penetration ability in the isolated intestine
additional information
enzyme catalytic domain homology modeling, overview
additional information
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enzyme catalytic domain homology modeling, overview
additional information
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the conserved residues Cys122, His292, and Asn312 form the typical cysteine protease catalytic triad. The enzyme sequence contains a specific hemoglobinase motif and might have a hemoglobinase -degrading function