3.4.22.B6: cathepsin B-like protease

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For detailed information about cathepsin B-like protease, go to the full flat file.

Reaction

the enzyme does not readily hyrolyze benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin (which is cleaved by cathespsin B). The enzyme is not able to cleave synthetic substrates having an Arg in position P2 =

Synonyms

AC-5 cathepsin B-like protease, CatB, CatB2, CathB-1, CathB2, CathB3, cathepsin B type protease, cathepsin B-like cysteine protease, cathepsin B-like cysteine protease 1, cathepsin B-like cysteine protease 2, cathepsin B-like cysteine proteinase, cathepsin B-like cysteine proteinase 1, cathepsin B-like cysteine proteinase 2, cathepsin B-like peptidase, cathepsin B-like protease, CBc1, CBc6, CBL1, CmCatB, CmCatB1, CmCatB2, CPB, CPC, CPC protease, eimeripain, HCB, LmacatB, LOC103512321, More, TbCatB, TcoCBc1, TcoCBc6, TrCB2

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B6 cathepsin B-like protease

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Results	in table
1	Activating Compound
15	AA Sequence
1	Application
1	CAS Registry Number
16	Cloned(Commentary)
1	Crystallization (Commentary)
51	Disease/ Diagnostics
10	General Information
7	IC50 Value
41	Inhibitors
16	kcat/KM [mM/s]
4	Ki Value [mM]
24	KM Value [mM]
8	Localization
12	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
31	Organism
5	pH Optimum
2	pH Range
3	pI Value
7	Posttranslational Modification
10	Protein Variants
9	Purification (Commentary)
1	Reaction
1	Reaction Type
28	Reference
28	Source Tissue
46	Substrates and Products (Substrate)
10	Subunits
43	Synonyms
2	Temperature Optimum [°C]
23	Turnover Number [1/s]

Application

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Application on EC 3.4.22.B6 - cathepsin B-like protease

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

medicine

Trypanosoma congolense

B2C323

TcoCBc1 elicits an important immune response in experimentally infected cattle. The protein is a potential therapeutic target and is a plausible antigen for Trypanosoma congolense diagnosis

679598