3.4.22.B6: cathepsin B-like protease
This is an abbreviated version!
For detailed information about cathepsin B-like protease, go to the full flat file.
Reaction
the enzyme does not readily hyrolyze benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin (which is cleaved by cathespsin B). The enzyme is not able to cleave synthetic substrates having an Arg in position P2 =
Synonyms
AC-5 cathepsin B-like protease, CatB, CatB2, CathB-1, CathB2, CathB3, cathepsin B type protease, cathepsin B-like cysteine protease, cathepsin B-like cysteine protease 1, cathepsin B-like cysteine protease 2, cathepsin B-like cysteine proteinase, cathepsin B-like cysteine proteinase 1, cathepsin B-like cysteine proteinase 2, cathepsin B-like peptidase, cathepsin B-like protease, CBc1, CBc6, CBL1, CmCatB, CmCatB1, CmCatB2, CPB, CPC, CPC protease, eimeripain, HCB, LmacatB, LOC103512321, More, TbCatB, TcoCBc1, TcoCBc6, TrCB2
ECTree
3.4.22.B6 cathepsin B-like proteaseAdvanced search results
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results (Inhibitors
Inhibitors on EC 3.4.22.B6 - cathepsin B-like protease
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
(1S,2S)-2-(((S)-1-((4-guanidinobutyl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)cyclopropanecarboxylic acid
-
i.e. E-64
acetyl-Leu-Val-lysinal
350 nM, 37°C, pH 4.5, 1 h, 15% inhibition
cathepsin L inhibitor 1
-
has a lower inhibitory effct on cathepsin B-like protease
CBZ-Phe-Gly-NHO-Bz-pMe
350 nM, 37°X, pH 4.5, 1 h, 87% inhibition
N-(L-3-trans-propylcarbamoyl-oxirane-2-carbonyl)-L-Ile-L-Pro
-
CA074, irreversible inhibitor
N-(L-3-trans-propylcarbamoyloxirane-2-carbonyl)-Ile-Pro-OH
CA-074, irreversible inhibitor
N-(Na-carbonyl-Cpd-Gln-Ala-al)-Leu
elastatinal, irreversible inhibitor
N-trans-(epoxysuccinyl)-L-leucine 4-guanidinobutylamide
E-64, irreversible inhibitor
CA-074
a specific cathepsin B inhibitor, the membrane-permeable derivative of CA-074, impairs invasion of epithelial MDBK cells by Eimeria tenella sporozoites
CA074
-
i.e. N-(L-3-trans-propylcarbamoyloxirane-2-carbonyl)-L-isoleucyl-L-proline
cystatin
Haemonchus contortus, GenBank accession number AF035945
-
Leishmania cysteine peptidase inhibitor 1
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i.e. ICP, inhibitor of CPs from family C1 clan A
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Leishmania cysteine peptidase inhibitor 1
-
i.e. ICP, inhibitor of CPs from family C1 clan A
-
Leishmania cysteine peptidase inhibitor 1
-
i.e. ICP, inhibitor of CPs from family C1 clan A
-
additional information
no significant inhibitory effects for pepstatin and PMSF
-
additional information
activity is unaffeceted by soyacystatin N
-
additional information
activity is unaffeceted by soyacystatin N
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