3.4.22.B6: cathepsin B-like protease
This is an abbreviated version!
For detailed information about cathepsin B-like protease, go to the full flat file.
Reaction
the enzyme does not readily hyrolyze benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin (which is cleaved by cathespsin B). The enzyme is not able to cleave synthetic substrates having an Arg in position P2
=
Synonyms
AC-5 cathepsin B-like protease, CatB, CatB2, CathB-1, CathB2, CathB3, cathepsin B type protease, cathepsin B-like cysteine protease, cathepsin B-like cysteine protease 1, cathepsin B-like cysteine protease 2, cathepsin B-like cysteine proteinase, cathepsin B-like cysteine proteinase 1, cathepsin B-like cysteine proteinase 2, cathepsin B-like peptidase, cathepsin B-like protease, CBc1, CBc6, CBL1, CmCatB, CmCatB1, CmCatB2, CPB, CPC, CPC protease, eimeripain, HCB, LmacatB, LOC103512321, More, TbCatB, TcoCBc1, TcoCBc6, TrCB2
ECTree
KCat KM Value
KCat KM Value on EC 3.4.22.B6 - cathepsin B-like protease
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1.6 - 957
Abz-GIVRAK(Dnp)
0.05 - 8
Z-Arg-Arg-7-amido-4-methylcoumarin
3.4 - 174
Z-Phe-Arg-7-amido-4-methylcoumarin
4.4
Abz-FRF(NO2)A
mutant H207A, pH 5.5, 37°C
18
Abz-FRF(NO2)A
mutant G336E, pH 5.5, 37°C
362
Abz-FRF(NO2)A
pH 5.5, 37°C
362
Abz-FRF(NO2)A
wild-type, pH 5.5, 37°C
1.6
Abz-GIVRAK(Dnp)
mutant H207A, pH 5.5, 37°C
104
Abz-GIVRAK(Dnp)
mutant G336E, pH 5.5, 37°C
957
Abz-GIVRAK(Dnp)
pH 5.5, 37°C
957
Abz-GIVRAK(Dnp)
wild-type, pH 5.5, 37°C
0.05
Z-Arg-Arg-7-amido-4-methylcoumarin
mutant H207A, pH 5.5, 37°C
2
Z-Arg-Arg-7-amido-4-methylcoumarin
pH 5.5, 37°C
2
Z-Arg-Arg-7-amido-4-methylcoumarin
wild-type, pH 5.5, 37°C
8
Z-Arg-Arg-7-amido-4-methylcoumarin
mutant G336E, pH 5.5, 37°C
3.4
Z-Phe-Arg-7-amido-4-methylcoumarin
mutant H207A, pH 5.5, 37°C
12
Z-Phe-Arg-7-amido-4-methylcoumarin
mutant G336E, pH 5.5, 37°C
174
Z-Phe-Arg-7-amido-4-methylcoumarin
pH 5.5, 37°C
174
Z-Phe-Arg-7-amido-4-methylcoumarin
wild-type, pH 5.5, 37°C