3.4.22.B6: cathepsin B-like protease
This is an abbreviated version!
For detailed information about cathepsin B-like protease, go to the full flat file.
Reaction
the enzyme does not readily hyrolyze benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin (which is cleaved by cathespsin B). The enzyme is not able to cleave synthetic substrates having an Arg in position P2
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Synonyms
AC-5 cathepsin B-like protease, CatB, CatB2, CathB-1, CathB2, CathB3, cathepsin B type protease, cathepsin B-like cysteine protease, cathepsin B-like cysteine protease 1, cathepsin B-like cysteine protease 2, cathepsin B-like cysteine proteinase, cathepsin B-like cysteine proteinase 1, cathepsin B-like cysteine proteinase 2, cathepsin B-like peptidase, cathepsin B-like protease, CBc1, CBc6, CBL1, CmCatB, CmCatB1, CmCatB2, CPB, CPC, CPC protease, eimeripain, HCB, LmacatB, LOC103512321, More, TbCatB, TcoCBc1, TcoCBc6, TrCB2
ECTree
Source Tissue
Source Tissue on EC 3.4.22.B6 - cathepsin B-like protease
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expression in virulence
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developing, HCB expression analysis during embryogenesis, overview
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of femal adult worms
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the expression in the gut is 175fold and 3333fold higher than in the remaining tissues and in the head, respectively
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neurons
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hippocampal
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the expression of DCcathB in nymph and adult is approximately 9fold greater than in egg
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in the sphere of yolk granules
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three isozymes of HCB
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extracellular and intracellular sporozoites
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high expression level
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the expression of DCcathB in nymph and adult is approximately 9fold greater than in egg
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expressed mainly in bloodstream form
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mainly
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female
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low expression level
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fourth-stage larvae, the mature enzyme is an excretory/secretory product of of L4 larval stage
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high expression level in stage L3, negligible in stage L1
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additional information
developmental expression analysis of gene AC-cathB-1, which is highly expressed in adult worms, overview
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additional information
developmental expression analysis of gene AC-cathB-1, which is highly expressed in adult worms, overview
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additional information
developmental expression analysis of gene AC-cathB-2, no expression in adult worm, overview
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additional information
developmental expression analysis of gene AC-cathB-2, no expression in adult worm, overview
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additional information
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enzyme expression throughout various developmental stages, L3, L4, adult male and female worms, immunohistochemic analysis
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additional information
the enzyme is expressed throughout sporulation and has a punctate distribution in the bodies of extra- and intracellular parasites, expression profile, overview
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additional information
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the enzyme is expressed throughout sporulation and has a punctate distribution in the bodies of extra- and intracellular parasites, expression profile, overview
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