3.4.22.B6: cathepsin B-like protease
This is an abbreviated version!
For detailed information about cathepsin B-like protease, go to the full flat file.
Reaction
the enzyme does not readily hyrolyze benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin (which is cleaved by cathespsin B). The enzyme is not able to cleave synthetic substrates having an Arg in position P2 =
Synonyms
AC-5 cathepsin B-like protease, CatB, CatB2, CathB-1, CathB2, CathB3, cathepsin B type protease, cathepsin B-like cysteine protease, cathepsin B-like cysteine protease 1, cathepsin B-like cysteine protease 2, cathepsin B-like cysteine proteinase, cathepsin B-like cysteine proteinase 1, cathepsin B-like cysteine proteinase 2, cathepsin B-like peptidase, cathepsin B-like protease, CBc1, CBc6, CBL1, CmCatB, CmCatB1, CmCatB2, CPB, CPC, CPC protease, eimeripain, HCB, LmacatB, LOC103512321, More, TbCatB, TcoCBc1, TcoCBc6, TrCB2
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Disease on EC 3.4.22.B6 - cathepsin B-like protease
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Carcinogenesis
Changes in tissue and serum activity of cathepsin B-like cysteine proteinase during colorectal carcinogenesis by 1,2-dimethylhydrazine in mice.
Carcinoma
Fluorescence demonstration of cathepsin B-like cysteine proteinase activity in lung squamous cell carcinomas and surrounding tissues.
Carcinoma, Squamous Cell
Fluorescence demonstration of cathepsin B-like cysteine proteinase activity in lung squamous cell carcinomas and surrounding tissues.
cathepsin b-like protease deficiency
A parasite cysteine protease is key to host protein degradation and iron acquisition.
Colorectal Neoplasms
Clinical experience with the testing of serum proteinase activity by cathepsin B-like sensitive amino acid derivatives of 7-amino-4-methylcoumarine.
Gingivitis
Identification of a cathepsin b-like protease in the crevicular fluid of gingivitis patients.
Infections
Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei.
Leukemia
Activity and inhibition by cytotoxic and antimetastatic drugs of cathepsin B-like cysteine proteinase in transplantable leukemias in mice.
Melanoma, Experimental
Properties of a plasma membrane-associated cathepsin B-like cysteine proteinase in metastatic B16 melanoma variants.
Neoplasms
Activity and inhibition by cytotoxic and antimetastatic drugs of cathepsin B-like cysteine proteinase in transplantable leukemias in mice.
Neoplasms
Involvement of a cathepsin B-like cysteine proteinase in platelet aggregation induced by tumor cells and their shed membrane vesicles.
Neoplasms
Properties of a plasma membrane-associated cathepsin B-like cysteine proteinase in metastatic B16 melanoma variants.
Trypanosomiasis, African
The Inhibition of Cysteine Proteases Rhodesain and TbCatB: a Valuable Approach to Treat Human African Trypanosomiasis.
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