3.4.22.B6: cathepsin B-like protease
This is an abbreviated version!
For detailed information about cathepsin B-like protease, go to the full flat file.
Reaction
the enzyme does not readily hyrolyze benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin (which is cleaved by cathespsin B). The enzyme is not able to cleave synthetic substrates having an Arg in position P2
=
Synonyms
AC-5 cathepsin B-like protease, CatB, CatB2, CathB-1, CathB2, CathB3, cathepsin B type protease, cathepsin B-like cysteine protease, cathepsin B-like cysteine protease 1, cathepsin B-like cysteine protease 2, cathepsin B-like cysteine proteinase, cathepsin B-like cysteine proteinase 1, cathepsin B-like cysteine proteinase 2, cathepsin B-like peptidase, cathepsin B-like protease, CBc1, CBc6, CBL1, CmCatB, CmCatB1, CmCatB2, CPB, CPC, CPC protease, eimeripain, HCB, LmacatB, LOC103512321, More, TbCatB, TcoCBc1, TcoCBc6, TrCB2
ECTree
Turnover Number
Turnover Number on EC 3.4.22.B6 - cathepsin B-like protease
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0.02 - 0.17
Abz-FRF(NO2)A
0.015 - 0.9
Abz-GIVRAK(Dnp)
0.145
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin
-
pH 5.5, 25°C, wild-type enzyme
1.05 - 7.6
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin
3 - 6
CBZ-Arg-Arg-7-amido-4-methylcoumarin
-
3.49
N2-benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin
-
1.09
Nalpha-benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin
-
0.005 - 0.05
Z-Arg-Arg-7-amido-4-methylcoumarin
0.14 - 1
Z-Phe-Arg-7-amido-4-methylcoumarin
0.02
Abz-FRF(NO2)A
mutant H207A, pH 5.5, 37°C
0.04
Abz-FRF(NO2)A
mutant G336E, pH 5.5, 37°C
0.17
Abz-FRF(NO2)A
pH 5.5, 37°C
0.17
Abz-FRF(NO2)A
wild-type, pH 5.5, 37°C
0.015
Abz-GIVRAK(Dnp)
mutant H207A, pH 5.5, 37°C
0.11
Abz-GIVRAK(Dnp)
mutant G336E, pH 5.5, 37°C
0.9
Abz-GIVRAK(Dnp)
pH 5.5, 37°C
0.9
Abz-GIVRAK(Dnp)
wild-type, pH 5.5, 37°C
1.05
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin
-
pH 5.5, 25°C, mutant enzyme G234E
6.6
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin
-
pH 5.5, 25°C, mutant enzyme G234E
7.6
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin
-
pH 5.5, 25°C, wild-type enzyme
0.005
Z-Arg-Arg-7-amido-4-methylcoumarin
mutant H207A, pH 5.5, 37°C
0.04
Z-Arg-Arg-7-amido-4-methylcoumarin
mutant G336E, pH 5.5, 37°C
0.05
Z-Arg-Arg-7-amido-4-methylcoumarin
pH 5.5, 37°C
0.05
Z-Arg-Arg-7-amido-4-methylcoumarin
wild-type, pH 5.5, 37°C
0.14
Z-Phe-Arg-7-amido-4-methylcoumarin
mutant G336E, pH 5.5, 37°C
0.14
Z-Phe-Arg-7-amido-4-methylcoumarin
mutant H207A, pH 5.5, 37°C
1
Z-Phe-Arg-7-amido-4-methylcoumarin
pH 5.5, 37°C
1
Z-Phe-Arg-7-amido-4-methylcoumarin
wild-type, pH 5.5, 37°C