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Literature summary for 3.4.22.B6 extracted from

  • Rieux, A.; Gras, S.; Lecaille, F.; Niepceron, A.; Katrib, M.; Smith, N.C.; Lalmanach, G.; Brossier, F.
    Eimeripain, a cathepsin B-like cysteine protease, expressed throughout sporulation of the apicomplexan parasite Eimeria tenella (2012), PLoS ONE, 7, e31914.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression of eimeripain fused to the fluorescent protein mCherry Eimeria tenella

Inhibitors

Inhibitors Comment Organism Structure
CA-074 a specific cathepsin B inhibitor, the membrane-permeable derivative of CA-074, impairs invasion of epithelial MDBK cells by Eimeria tenella sporozoites Eimeria tenella

Organism

Organism UniProt Comment Textmining
Eimeria tenella G9IBU6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information the enzyme is expressed throughout sporulation and has a punctate distribution in the bodies of extra- and intracellular parasites, expression profile, overview Eimeria tenella
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oocyte
-
Eimeria tenella
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sporozoite extracellular and intracellular sporozoites Eimeria tenella
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Z-Leu-Arg-7-amido-4-methylcoumarin + H2O
-
Eimeria tenella Z-Leu-Arg + 7-amino-4-methylcoumarin
-
?
Z-Phe-Arg-7-amido-4-methylcoumarin + H2O
-
Eimeria tenella Z-Phe-Arg + 7-amino-4-methylcoumarin
-
?

Synonyms

Synonyms Comment Organism
cathepsin B-like cysteine protease
-
Eimeria tenella
eimeripain
-
Eimeria tenella

General Information

General Information Comment Organism
evolution the enzyme is classified as a papain-like protease with similar characteristics to toxopain-1 from the related apicomplexan parasite, Toxoplasma gondii Eimeria tenella
additional information enzyme catalytic domain homology modeling, overview Eimeria tenella