3.4.22.55: caspase-2
This is an abbreviated version!
For detailed information about caspase-2, go to the full flat file.
Word Map on EC 3.4.22.55
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3.4.22.55
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caspases
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bcl-2
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necrosis
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bid
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proapoptotic
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anti-apoptotic
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parp
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raidd
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apoptosis-inducing
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caspase-dependent
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z-vad-fmk
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p53-induced
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tunel
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jurkat
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polyadp-ribose
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casps
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mitochondria-mediated
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non-apoptotic
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pan-caspase
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apaf-1
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apoptosome
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caspase-mediated
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death-inducing
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cpp32
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fasl
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z-devd-fmk
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executioner
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xiap
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damage-induced
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etoposide-induced
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anti-fas
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prodomains
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p53-dependent
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trail-induced
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executor
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bh3-only
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ac-devd-cho
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apoptogenic
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trail-mediated
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procaspase
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caspase-10
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chk1
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beta-converting
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mitochondria-dependent
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medicine
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diagnostics
- 3.4.22.55
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caspases
- bcl-2
- necrosis
- bid
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proapoptotic
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anti-apoptotic
- parp
- raidd
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apoptosis-inducing
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caspase-dependent
- z-vad-fmk
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p53-induced
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tunel
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jurkat
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polyadp-ribose
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casps
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mitochondria-mediated
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non-apoptotic
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pan-caspase
- apaf-1
- apoptosome
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caspase-mediated
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death-inducing
- cpp32
- fasl
- z-devd-fmk
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executioner
- xiap
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damage-induced
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etoposide-induced
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anti-fas
- prodomains
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p53-dependent
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trail-induced
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executor
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bh3-only
- ac-devd-cho
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apoptogenic
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trail-mediated
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procaspase
- caspase-10
- chk1
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beta-converting
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mitochondria-dependent
- medicine
- diagnostics
Reaction
strict requirement for an Asp residue at P1, with Asp316 being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-/- =
Synonyms
AjCASP, C14.006, CASP-2, Casp2, caspase 2, caspase-2, caspase-2L, caspase-2S, ICH-1, ICH-1 protease, ICH-1L/1S, NEDD-2
ECTree
3.4.22.55 caspase-2Advanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 3.4.22.55 - caspase-2
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
eukaryotic translation initiation factor 4B + H2O
?
Asp563 in eukaryotic translation initiation factor 4B is a caspase-2-preferred cleavage site
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-
?
Mdm2 protein + H2O
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caspase-2 cleaves and inhibits Mdm2 and thereby promotes the stability of the tumor-suppressor p53
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?
Val-Asp-Val-Ala-Asp-7-amido-4-methylcoumarin + H2O
Val-Asp-Val-Ala-Asp + 7-amino-4-methylcoumarin
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?
BID + H2O
?
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caspase-2 cleaves BID in response 16 to endoplasmic reticulum stress. Resistance to endoplasmic reticulum stress-induced apoptosis can be conferred by inhibiting caspase-2 activity
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?
Bid + H2O
tBid + ?
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active caspase-2 cleaves Bid to form tBid, which induces mitochondrial outer membrane permeabilization
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?
Bid + H2O
tBid + ?
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active caspase-2 cleaves Bid to form tBid, which induces mitochondrial outer membrane permeabilization
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?
MDM2 + H2O
MDM2 p60 + ?
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active caspase-2 cleaves MDM2 to form MDM2 p60, which binds to and stabilizes p53
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?
MDM2 + H2O
MDM2 p60 + ?
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active caspase-2 cleaves MDM2 to form MDM2 p60, which binds to and stabilizes p53
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?
tau protein + H2O
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caspase-2 cleavage of tau at Asp314 impairs cognitive and synaptic function in animal and cellular models of tauopathies by promoting the missorting of tau to dendritic spines. The truncation product, DELTAtau314, resists fibrillation and is present at higher levels in brains from cognitively impaired mice and humans with Alzheimer's disease
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?
tau protein + H2O
?
caspase-2 cleavage of tau at Asp314 impairs cognitive and synaptic function in animal and cellular models of tauopathies by promoting the missorting of tau to dendritic spines. The truncation product, DELTAtau314, resists fibrillation and is present at higher levels in brains from cognitively impaired mice and humans with Alzheimer's disease
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?
additional information
?
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caspase-2 activation regulates PS-341-induced mitochondrial depolarization and apoptosis, suggesting that caspase-2 can serve as a link between lysosomal and mitochondrial permeabilization
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?
additional information
?
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caspase-2 initiates caspase cascade after trichostatin A treatment and involves the formation of the PIDDosome (a complex of caspase-2-CRADD/RAIDD-PIDD)
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?
additional information
?
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phenotype of animals deficient in caspase-2: increased number of oocytes at birth, and oocytes are less susceptible to doxorubicin-induced apoptosis. B cells are partially resistant to death induction by granzyme B, accelerated apoptosis of facial motor neurons
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?
additional information
?
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caspase 2 is involved in ischemia-reperfusion-induced germ-cell-specific apoptosis
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?
additional information
?
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caspase-2 is a substrate for caspase-8 and caspase-3
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?
