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3.4.22.55: caspase-2

This is an abbreviated version!
For detailed information about caspase-2, go to the full flat file.

Word Map on EC 3.4.22.55

Reaction

strict requirement for an Asp residue at P1, with Asp316 being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-/- =

Synonyms

AjCASP, C14.006, CASP-2, Casp2, caspase 2, caspase-2, caspase-2L, caspase-2S, ICH-1, ICH-1 protease, ICH-1L/1S, NEDD-2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.55 caspase-2

Expression

Expression on EC 3.4.22.55 - caspase-2

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
caspase-2 enzyme activity in both Brucella abortus strain RB51- and S2308-infected bone marrow-derived dendritic cells is significantly up-regulated at 1 h, 4 h, and 24 h post infection
caspase-2 induction by p53
-
downregulated duiring the development of the central nervous system
-
highly expressed in neural precursor cells
-
significantly induced by lipopolysaccharide