Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P29594 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone marrow-derived dendritic cell | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
Casp2 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | caspase-2 enzyme activity in both Brucella abortus strain RB51- and S2308-infected bone marrow-derived dendritic cells is significantly up-regulated at 1 h, 4 h, and 24 h post infection | up |
General Information | Comment | Organism |
---|---|---|
malfunction | maturation, activation, and cytokine secretion are significantly impaired in Caspase-2 knockout cells infected with Brucella abortus strain RB51 or Salmonella typhimurium strain SL1344 | Mus musculus |
physiological function | Brucella abortus strain RB51- and S2308-induced BMDC cell death is regulated by caspase-2. The enzyme is required for naive T-lymphocyte proliferation following stimulation with RB51-infected bone marrow-derived dendritic cells | Mus musculus |