3.4.22.55: caspase-2

This is an abbreviated version!
For detailed information about caspase-2, go to the full flat file.

Word Map on EC 3.4.22.55

3.4.22.55

caspases

bcl-2

necrosis

bid

proapoptotic

anti-apoptotic

parp

raidd

apoptosis-inducing

caspase-dependent

z-vad-fmk

p53-induced

tunel

jurkat

polyadp-ribose

casps

mitochondria-mediated

non-apoptotic

pan-caspase

apaf-1

apoptosome

caspase-mediated

death-inducing

cpp32

fasl

z-devd-fmk

executioner

xiap

damage-induced

etoposide-induced

anti-fas

prodomains

p53-dependent

trail-induced

executor

bh3-only

ac-devd-cho

apoptogenic

trail-mediated

procaspase

caspase-10

chk1

beta-converting

mitochondria-dependent

medicine

diagnostics

Reaction

strict requirement for an Asp residue at P1, with Asp316 being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-/- =

Synonyms

AjCASP, C14.006, CASP-2, Casp2, caspase 2, caspase-2, caspase-2L, caspase-2S, ICH-1, ICH-1 protease, ICH-1L/1S, NEDD-2

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.22 Cysteine endopeptidases

3.4.22.55 caspase-2

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Results	in table
36	Activating Compound
27	AA Sequence
2	Application
1	CAS Registry Number
21	Cloned(Commentary)
2	Crystallization (Commentary)
1015	Disease/ Diagnostics
5	Expression
54	General Information
3	IC50 Value
51	Inhibitors
3	Ki Value [mM]
4	KM Value [mM]
38	Localization
1	Metals/Ions
10	Molecular Weight [Da]
71	Natural Substrates/ Products (Substrates)
104	Organism
36	PDB ID
3	pH Optimum
1	pI Value
16	Posttranslational Modification
23	Protein Variants
9	Purification (Commentary)
2	Reaction
1	Reaction Type
104	Reference
138	Source Tissue
117	Substrates and Products (Substrate)
19	Subunits
64	Synonyms
2	Temperature Optimum [°C]
2	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 3.4.22.55 - caspase-2

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2-chloro-2'-deoxyadenosine

amyloid beta1-42

the levels of activated caspase-2 in cultured hippocampal neurons significantly increase within 30 min of treatment with 0.003 mM amyloid beta1-42

ATM/ATR

caspase-10

is required for effective processing of caspase-2

666511

CD95-death-inducing signaling complex

cyclin D3

lovastatin

0.05 mM for 24 h, increases caspase-2 gene expression

666351

P53

2 entries

p53-induced protein with a death domain

Homo sapiens

PIDD, caspase-2 is activated by the p53 target gene product PIDD, i.e. LRDD or leucine-rich repeats and death domain containing, in a complex called the caspase-2-PIDDosome

718112

p53-inducible death domain-containing protein

PIDD

p73

palmitate

caspase-2 is activated by an overabundance of saturated long-chain fatty acids like palmitate. Inhibition of amino acid transamination by 10 mM aminooxyacetate blocks caspase activation

PIDD protein

PIDDosome

protein phosphatase 1

RAIDD

RAIDD protein

silibinin

caspase-2 and caspase-8 can activate each other in response to silibinin

664533

sterol regulatory element binding protein 2

Homo sapiens

P42575

increases caspase-2 gene expression

666351

additional information

11 entries