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Literature summary for 3.4.22.55 extracted from

  • Johnson, E.S.; Lindblom, K.R.; Robeson, A.; Stevens, R.D.; Ilkayeva, O.R.; Newgard, C.B.; Kornbluth, S.; Andersen, J.L.
    Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis (2013), J. Biol. Chem., 288, 14463-14475.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
palmitate caspase-2 is activated by an overabundance of saturated long-chain fatty acids like palmitate. Inhibition of amino acid transamination by 10 mM aminooxyacetate blocks caspase activation Xenopus laevis

Organism

Organism UniProt Comment Textmining
Xenopus laevis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
egg
-
 Xenopus laevis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-DEVD-4-nitroanilide + H2O
-
 Xenopus laevis N-acetyl-DEVD + 4-nitroaniline
-
 ?

General Information

General Information Comment Organism
physiological function caspase-2 plays a role in lipoapoptosis and is required for cell death Xenopus laevis