Activating Compound | Comment | Organism | Structure |
---|---|---|---|
amyloid beta1-42 | the levels of activated caspase-2 in cultured hippocampal neurons significantly increase within 30 min of treatment with 0.003 mM amyloid beta1-42 | Rattus norvegicus | |
additional information | caspase-2 is rapidly activated by nerve growth factor deprivation | Rattus norvegicus | |
RAIDD | caspase-2 activation is dependent on the adaptor protein RAIDD | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
biotinylated VAD-fluoromethylketone | irreversible pan-caspase inhibitor | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
45000 | - |
x * 45000, SDS-PAGE | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
CUX1 + H2O | Rattus norvegicus | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P55215 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hippocampus | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CUX1 + H2O | - |
Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 45000, SDS-PAGE | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
Casp2 | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme is essential for c-Jun transcriptional activation and Bim induction in in neurons subjected to apoptotic stimuli | Rattus norvegicus |