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Literature summary for 3.4.22.55 extracted from
- Caspase-2 function in response to DNA damage (2005), Biochem. Biophys. Res. Commun., 331, 859-867.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 2-chloro-2'-deoxyadenosine | - |
Homo sapiens |  |
| cyclin D3 | - |
Homo sapiens | |
| p53-inducible death domain-containing protein | PIDD | Homo sapiens | |
| p73 | - |
Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| diagnostics | high level of inactive, non-processed caspase-2 together with caspase-3 is used as a predictor of survival and complete remission in adults with acute myeloblastic or lymphoblastic leukemias | Homo sapiens |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| glucocorticoid modulatory element-binding protein 1 | GMEB1, endogenous inhibitor of pro-caspase-2 activation | Homo sapiens | |
| SP600125 | inhibits caspase-2 partially | Homo sapiens | |
| Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-CH2F | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | soluble | Homo sapiens | 5737 | - |
| Golgi apparatus | - |
Homo sapiens | 5794 | - |
| mitochondrion | - |
Homo sapiens | 5739 | - |
| nucleus | - |
Homo sapiens | 5634 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 51000 | - |
monomer, inactive form, pro-caspase-2 | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P42575 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| astrocytoma cell | - |
Homo sapiens | - |
| brain | embryonic and adult | Homo sapiens | - |
| brain | embryonic and adult, highest expression in embryonic brain | Homo sapiens | - |
| heart | - |
Homo sapiens | - |
| HeLa cell | - |
Homo sapiens | - |
| JURKAT cell | - |
Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| THP-1 cell | - |
Homo sapiens | - |
| thymus | adult | Homo sapiens | - |
| U-937 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha-II-spectrin + H2O | - |
Homo sapiens | ? | - |
? | |
| golgin-160 + H2O | - |
Homo sapiens | ? | - |
? | |
| PKC-delta + H2O | in JURKAT cells | Homo sapiens | ? | - |
? | |
| VDVAD + H2O | - |
Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | active form | Homo sapiens |
| monomer | inactive form | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| caspase-2 | - |
Homo sapiens |
| caspase-2L | 435 amino acids, overexpression induces cell death | Homo sapiens |
| caspase-2S | 312 amino acids, overexpression suppresses cell death | Homo sapiens |
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