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3.4.22.55: caspase-2

This is an abbreviated version!
For detailed information about caspase-2, go to the full flat file.

Word Map on EC 3.4.22.55

Reaction

strict requirement for an Asp residue at P1, with Asp316 being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-/- =

Synonyms

AjCASP, C14.006, CASP-2, Casp2, caspase 2, caspase-2, caspase-2L, caspase-2S, ICH-1, ICH-1 protease, ICH-1L/1S, NEDD-2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.55 caspase-2

Source Tissue

Source Tissue on EC 3.4.22.55 - caspase-2

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
treatment of melanoma cells with terfenadine induced DNA damage and caspases 2 activation. A selective inhibitor of caspase-2 (benzyloxycarbonyl-VDVAD-fluoromethylketone) protects melanoma cells from terfenadine-induced apoptosis
Manually annotated by BRENDA team
-
histone deacetylase inhibition leads to decreased protein kinase casein kinase 2 activity, which is followed by caspase-2 activation and partial cleavage of caspase-8 that sensitizes the tumor cell to TRAIL-induced apoptosis
Manually annotated by BRENDA team
-
PS-341 (bortezomib) induces a dose-dependent apoptosis in association with reactive oxygen species generation and cleavage of caspase-2 to its 33- and 14-kDa fragments. PS-341-induced caspase-2 activation is attenuated by a selective pharmacological inhibitor of cathepsin B (R-3032). Caspase-2 regulates mitochondrial permeability
Manually annotated by BRENDA team
high expression level
Manually annotated by BRENDA team
immunostaining for caspase-2 increases as the luteal phase progresses
Manually annotated by BRENDA team
human esophageal cancer cell line
Manually annotated by BRENDA team
human esophageal cancer cell line
Manually annotated by BRENDA team
hepatoma cell line
Manually annotated by BRENDA team
-
thrombin initiates EMP generation from the human microvascular endothelial cell line HMEC-1. Caspase-2 plays a role in release of endothelial microparticles by controlling the proteolytic activation of ROCK-II
Manually annotated by BRENDA team
human malignant glioma cell line
Manually annotated by BRENDA team
caspase-2 levels are significantly reduced in human lung adenocarcinoma with wild-type p53
Manually annotated by BRENDA team
-
caspase 2 activation is required for release of cytochrome c and cell death
Manually annotated by BRENDA team
human colon cancer cell line
Manually annotated by BRENDA team
human pancreatic cancer cell
Manually annotated by BRENDA team
human esophageal cancer cell line
Manually annotated by BRENDA team
additional information
isoform casp-2S is undetectable in the SKOV3, H-1299 and HCT-116 p53-deficient cells
Manually annotated by BRENDA team