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Literature summary for 3.4.22.55 extracted from

  • Kumar, S.
    Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more? (2009), Nat. Rev. Cancer, 9, 897-903.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Mus musculus 5634
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the initial activation of caspase 2 seems to be mediated by dimerization not processing, this generates a partially active enzyme that is further activated by autoprocessing (self cleavage). Additional processing, which is presumably mediated by active effector caspases (caspases 3 and 7) results in the generation of caspase 2 p19 and p12 subunits. Given that caspase 2 can be processed by caspases 3 and 7, and that loss or inhibition of these caspases or their upstream activators (caspase 9 and APAF1) leads to an inhibition of caspase 2 cleavage Mus musculus

Synonyms

Synonyms Comment Organism
caspase 2
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus downregulated duiring the development of the central nervous system down
Mus musculus highly expressed in neural precursor cells up

General Information

General Information Comment Organism
malfunction Casp2-null animals develop normally, and thymocytes and neurons derived from them seem to undergo similar levels of apoptosis to those from wild-type littermates. Nevertheless, several subtle phenotypes are associated with the Casp2-knockout mice: Casp2-knockout females have a slight increase in the number of oocytes and Casp2–/– oocytes show reduced apoptosis in response to treatment with doxorubicin. The neurons derived from Casp2-null mice are resistant to beta-amyloid-mediated death, which suggests a role for caspase 2 in neuronal death. Casp2-deficient mice also show signs of premature ageing, including accumulation of oxidative damage. Mouse embryonic fibroblasts from Casp2-deficient animals show a reduced or delayed apoptotic response to some cytotoxic drugs, have an aberrant DNA damage and cell cycle response and are readily transformed when they are challenged by oncogene expression. Mus musculus
physiological function caspase 2 is thought be a downstream caspase Mus musculus