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Literature summary for 3.4.22.55 extracted from

  • Han, C.; Zhao, R.; Kroger, J.; Qu, M.; Wani, A.A.; Wang, Q.E.
    Caspase-2 short isoform interacts with membrane-associated cytoskeleton proteins to inhibit apoptosis (2013), PLoS ONE, 8, e67033.
    View publication on PubMedView publication on EuropePMC

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
33000
-
x * 33000, isoform casp-2S, SDS-PAGE Homo sapiens
45000
-
x * 45000, isoform casp-2L, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CUX1 + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P42575
-
-

Purification (Commentary)

Purification (Comment) Organism
anti-FLAG affinity gel chromatography, and gel filtration Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
2008 cell
-
Homo sapiens
-
2008C13 cell
-
Homo sapiens
-
A-2780 cell
-
Homo sapiens
-
A-549 cell
-
Homo sapiens
-
A2780/CDDP cell
-
Homo sapiens
-
H-1299 cell
-
Homo sapiens
-
H-460 cell
-
Homo sapiens
-
HeLa cell
-
Homo sapiens
-
additional information isoform casp-2S is undetectable in the SKOV3, H-1299 and HCT-116 p53-deficient cells Homo sapiens
-
ovarian cancer cell
-
Homo sapiens
-
PEO-1 cell
-
Homo sapiens
-
PEO-4 cell
-
Homo sapiens
-
SKOV-3 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CUX1 + H2O
-
Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
? x * 33000, isoform casp-2S, SDS-PAGE Homo sapiens
? x * 45000, isoform casp-2L, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
CASP-2
-
Homo sapiens

General Information

General Information Comment Organism
physiological function the long isoform, casp-2L, promotes apoptosis, whereas the short isoform, casp-2S, inhibits apoptosis. Isoform casp-2S is responsible for inhibiting DNA damage-induced cytoplasmic fodrin cleavage independent of cellular p53 status, and prevents cisplatin-induced membrane blebbing thereby affecting cellular apoptosis Homo sapiens