Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
33000 | - |
x * 33000, isoform casp-2S, SDS-PAGE | Homo sapiens |
45000 | - |
x * 45000, isoform casp-2L, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
CUX1 + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P42575 | - |
- |
Purification (Comment) | Organism |
---|---|
anti-FLAG affinity gel chromatography, and gel filtration | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
2008 cell | - |
Homo sapiens | - |
2008C13 cell | - |
Homo sapiens | - |
A-2780 cell | - |
Homo sapiens | - |
A-549 cell | - |
Homo sapiens | - |
A2780/CDDP cell | - |
Homo sapiens | - |
H-1299 cell | - |
Homo sapiens | - |
H-460 cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
additional information | isoform casp-2S is undetectable in the SKOV3, H-1299 and HCT-116 p53-deficient cells | Homo sapiens | - |
ovarian cancer cell | - |
Homo sapiens | - |
PEO-1 cell | - |
Homo sapiens | - |
PEO-4 cell | - |
Homo sapiens | - |
SKOV-3 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CUX1 + H2O | - |
Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 33000, isoform casp-2S, SDS-PAGE | Homo sapiens |
? | x * 45000, isoform casp-2L, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
CASP-2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the long isoform, casp-2L, promotes apoptosis, whereas the short isoform, casp-2S, inhibits apoptosis. Isoform casp-2S is responsible for inhibiting DNA damage-induced cytoplasmic fodrin cleavage independent of cellular p53 status, and prevents cisplatin-induced membrane blebbing thereby affecting cellular apoptosis | Homo sapiens |