Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.4.22.43: cathepsin V

This is an abbreviated version!
For detailed information about cathepsin V, go to the full flat file.

Word Map on EC 3.4.22.43

Reaction

The recombinant enzyme hydrolyses proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec) =

Synonyms

cathepsin L2, cathepsin L2/V, cathepsin like 2, cathepsin U, cathepsin V, cathepsin V/L2, cathepsin-V, CatV, CL2, CTSL2, CTSV, CV/L2, hcatV, More, stratum corneum thiol protease

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.43 cathepsin V

Disease

topprint

Disease on EC 3.4.22.43 - cathepsin V

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Alopecia
Evaluation of the CTSL2 Gene as a Candidate Gene For Alopecia X in Pomeranians and Keeshonden.
Arthritis
Polymorphisms in the cathepsin L2 (CTSL2) gene show association with type 1 diabetes and early-onset myasthenia gravis.
Arthritis, Juvenile
Polymorphisms in the cathepsin L2 (CTSL2) gene show association with type 1 diabetes and early-onset myasthenia gravis.
Arthritis, Rheumatoid
Polymorphisms in the cathepsin L2 (CTSL2) gene show association with type 1 diabetes and early-onset myasthenia gravis.
Atherosclerosis
Solution phase synthesis of a combinatorial library of chalcones and flavones as potent cathepsin V inhibitors.
Autoimmune Diseases
Polymorphisms in the cathepsin L2 (CTSL2) gene show association with type 1 diabetes and early-onset myasthenia gravis.
Breast Neoplasms
An exploratory study of host polymorphisms in genes that clinically characterize breast cancer tumors and pretreatment cognitive performance in breast cancer survivors.
Cathepsin V suppresses GATA3 protein expression in luminal A breast cancer.
Carcinogenesis
Cathepsin V suppresses GATA3 protein expression in luminal A breast cancer.
Carcinoma
Significance of nuclear cathepsin V in normal thyroid epithelial and carcinoma cells.
Carcinoma, Ductal
Prognostic significance of cathepsin V (CTSV/CTSL2) in breast ductal carcinoma in situ.
Carcinoma, Hepatocellular
Elevated CTSL2 expression is associated with an adverse prognosis in hepatocellular carcinoma.
Carcinoma, Intraductal, Noninfiltrating
Prognostic significance of cathepsin V (CTSV/CTSL2) in breast ductal carcinoma in situ.
Colorectal Neoplasms
Cathepsin V Mediates the Tazarotene-induced Gene 1-induced Reduction in Invasion in Colorectal Cancer Cells.
Dermatitis, Atopic
The cystatin M / E-controlled pathway of skin barrier formation: expression of its key components in psoriasis and atopic dermatitis.
Endometrial Neoplasms
Expression of cysteine protease cathepsin L is increased in endometrial cancer and correlates with expression of growth regulatory genes.
Goiter
Significance of nuclear cathepsin V in normal thyroid epithelial and carcinoma cells.
Hyperhomocysteinemia
HMGB1 mediates homocysteine-induced endothelial cells pyroptosis via cathepsin V-dependent pathway.
Keratoconus
Increased levels of catalase and cathepsin V/L2 but decreased TIMP-1 in keratoconus corneas: evidence that oxidative stress plays a role in this disorder.
Lung Neoplasms
Manipulating substrate and pH in zymography protocols selectively distinguishes cathepsins K, L, S, and V activity in cells and tissues.
Mucopolysaccharidoses
The abnormal accumulation of heparan sulfate in patients with mucopolysaccharidosis prevents the elastolytic activity of cathepsin V.
Myasthenia Gravis
Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis.
Neoplasm Metastasis
Cathepsin V suppresses GATA3 protein expression in luminal A breast cancer.
Determination of cathepsin V activity and intracellular trafficking by N-glycosylation.
Neoplasms
An exploratory study of host polymorphisms in genes that clinically characterize breast cancer tumors and pretreatment cognitive performance in breast cancer survivors.
Cathepsin V suppresses GATA3 protein expression in luminal A breast cancer.
CTSL2 is a pro-apoptotic target of E2F1 and a modulator of histone deacetylase inhibitor and DNA damage-induced apoptosis.
Determination of cathepsin V activity and intracellular trafficking by N-glycosylation.
Elevated CTSL2 expression is associated with an adverse prognosis in hepatocellular carcinoma.
Expression of cysteine protease cathepsin L is increased in endometrial cancer and correlates with expression of growth regulatory genes.
Manipulating substrate and pH in zymography protocols selectively distinguishes cathepsins K, L, S, and V activity in cells and tissues.
Neuroblastoma
Human cathepsin V protease participates in the production of enkephalin and NPY neurotransmitters.
Placenta Accreta
Possible Association between Cathepsin V and the Development of Placenta Accreta Spectrum Disorders.
Psoriasis
The cystatin M / E-controlled pathway of skin barrier formation: expression of its key components in psoriasis and atopic dermatitis.
Sarcoidosis, Pulmonary
Endostatin and cathepsin-V in bronchoalveolar lavage fluid of patients with pulmonary sarcoidosis.
Scleroderma, Systemic
Decreased cathepsin V expression due to Fli1 deficiency contributes to the development of dermal fibrosis and proliferative vasculopathy in systemic sclerosis.
Thyroid Cancer, Papillary
Significance of nuclear cathepsin V in normal thyroid epithelial and carcinoma cells.
Vascular Diseases
l-Homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia.