Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.4.22.34: Legumain

This is an abbreviated version!
For detailed information about Legumain, go to the full flat file.

Word Map on EC 3.4.22.34

Reaction

hydrolysis of proteins and small molecule substrates at -Asn-/-Xaa- bonds =

Synonyms

AEP, Antigen Sj32, Antigen SM32, As-specific vacuolar cysteine proteinase, Asn-specific vacuolar cysteine proteinase, asparagine endopeptidase, asparaginly endopeptidase, asparaginyl endopepidase, Asparaginyl endopeptidase, asparaginyl endopeptidase legumain, asparaginyl endopeptidase,, asparaginyl proteinase, asparaginyl-specific cysteine endopeptidase, asparagyl-endopeptidase, aspartate-specific endopeptidase, AtLEGgamma, Bean endopeptidase, C197 legumain, c197 Sm32, cysteine protease 1, hemoglobinase, HlLgm, HlLgm2, IrAE, IrAE protein, isae1, isae2, LeG, LEG-1, Leg-2, Leg-4, Leg1, Leg2, Leg3, Leg4, Leg5, legumain, legumain-1, LGMN, lysosomal asparaginycysteine endopeptidase, lysosomal asparaginyl endopeptidase, lysosomal cysteine proteinase, More, N197 legumain, osteoclast inhibitory peptide 2, Ov-aep-1, Phaseolin, Proteinase B, PrVPE1, schistosome legumain, Sj32, Sm32, SmAE, SmAE protein, SPAE, TcLEG3, TcLEG6, TcLEG9, TvAE1, vacuolar processing enzyme, vacuolar processing enzyme 1a, vacuolar processing enzyme 1b, vacuolar processing enzyme 2, vacuolar processing enzyme 3, Vicilin peptidohydrolase, VPE, VPE1a, VPE1b, VPE2, VPE3

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.34 Legumain

IC50 Value

IC50 Value on EC 3.4.22.34 - Legumain

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0000093
(1-[[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]carbonyl]cyclopropyl)carbamic acid
Homo sapiens
-
pH 5.8, temperature not specified in the publication
0.0000044 - 0.0000086
(1-[[(2S)-2-[[2-(2-amino-2-oxoethyl)-2-[[(2S,3S)-3-(ethoxycarbonyl)oxiran-2-yl]carbonyl]hydrazinyl]carbonyl]pyrrolidin-1-yl]carbonyl]cyclopropyl)carbamic acid
0.0000083
(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidine-1-carboxylic acid
Homo sapiens
-
pH 5.8, temperature not specified in the publication
0.0000093
(2S)-2-[[2-(2-amino-2-oxoethyl)-2-[[(2S,3S)-3-(ethoxycarbonyl)oxiran-2-yl]carbonyl]hydrazinyl]carbonyl]pyrrolidine-1-carboxylic acid
Homo sapiens
-
pH 5.8, temperature not specified in the publication
0.005854
(2S)-N-[(1S)-3-amino-1-cyano-3-oxopropyl]-2-[[(2',3'-difluoro[1,1'-biphenyl]-4-yl)methyl](methanesulfonyl)amino]butanamide
Homo sapiens
pH 7.4, 37°C
0.001
(3-[[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]carbonyl]phenyl)carbamic acid
Homo sapiens
-
pH 5.8, temperature not specified in the publication
0.000704
(3S)-3-[(1-acetyl-L-prolyl)amino]-5-[(2,6-dimethylbenzoyl)oxy]-4-oxopentanoic acid
Mus musculus
-
pH 7.4
0.000267
(4-[[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]carbonyl]benzyl)carbamic acid
Homo sapiens
-
pH 5.8, temperature not specified in the publication
0.000638
2-[[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]carbonyl]piperidine-1-carboxylic acid
Homo sapiens
-
pH 5.8, temperature not specified in the publication
0.001
3-[[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]carbonyl]-3,4-dihydroisoquinoline-2(1H)-carboxylic acid
Homo sapiens
-
pH 5.8, temperature not specified in the publication
0.000167
4-[[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]carbonyl]-1,3-thiazolidine-3-carboxylic acid
Homo sapiens
-
pH 5.8, temperature not specified in the publication
0.00075
Boc-azaAsn-CH=CH-COOEt
Ixodes ricinus
-
pH 6.8, 25°C
0.00003 - 0.000045
Boc-Piz-Ala-Ala-azaAsn-CH=CH-CON(Bzl)2
0.000005 - 0.000068
Boc-Piz-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
0.00002 - 0.000058
Boc-Piz-Ala-Ala-azaAsn-CH=CH-CON(CH3)CH2-1-naphthyl
0.0000075 - 0.000045
Boc-Piz-Ala-Ala-azaAsn-CH=CH-COOBzl
0.0000085 - 0.00008
Boc-Piz-Ala-Ala-azaAsn-CH=CH-COOEt
0.00008 - 0.00027
Boc-Piz-Ala-Ala-azaAsn-EP(S,S)-CON(Bzl)2
0.0000045 - 0.000031
Cbz-Ala-Ala-azaAsn-CH=CH-COOEt
0.00000052 - 0.00028
Cbz-Ala-Ile-azaAsn-CH=CH-COOEt
0.0005
CBZ-Ala-Phe-azaAsn-CH=CH-CO-tetrahydroisoquinoline
Ixodes ricinus
-
pH 6.8, 25°C
0.0018
CBZ-Ala-Phe-azaAsn-CH=CH-CONHCH2-furyl
Ixodes ricinus
-
pH 6.8, 25°C
0.000013 - 0.0005
Cbz-Ala-Val-azaAsn-CH=CH-CO-tetrahydroquinoline
0.00035 - 0.00105
Cbz-Ala-Val-azaAsn-CH=CH-CONHCH2-1-naphthyl
0.000065 - 0.0001
Cbz-Ala-Val-azaAsn-CH=CH-COOEt
0.00000037 - 0.00005
Cbz-Piz-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
0.00000035 - 0.00007
Cbz-Piz-Ala-Ala-azaAsn-CH=CH-CON(CH3)CH2-1-naphthyl
0.00000014 - 0.00007
Cbz-Piz-Ala-Ala-azaAsn-CH=CH-COOEt
0.00075 - 0.0008
Cbz-Piz-Ala-azaAsn-CH=CH-CO-tetrahydroisoquinoline
0.00075 - 0.00085
Cbz-Piz-Ala-azaAsn-CH=CH-CO-tetrahydroquinoline
0.0083
ethyl (2E)-4-[1-(2-amino-2-oxoethyl)-2-[[(2S)-1-(2-oxopropanoyl)pyrrolidin-2-yl]carbonyl]hydrazinyl]-4-oxobut-2-enoate
Mus musculus
-
in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.000141
ethyl (2E)-4-[2-([(2S)-1-[(2E)-2-(acetylamino)but-2-enoyl]pyrrolidin-2-yl]carbonyl)-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
Mus musculus
-
in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.001
ethyl (2E)-4-[2-([(2S)-1-[(2R)-2-(acetylamino)-3-(4-hydroxy-3-nitrophenyl)propanoyl]pyrrolidin-2-yl]carbonyl)-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
Mus musculus
-
IC50 above 0.001 mM, in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.0000065
ethyl (2E)-4-[2-([(2S)-1-[(2R)-2-(acetylamino)butanoyl]pyrrolidin-2-yl]carbonyl)-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
Mus musculus
-
in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.000017
ethyl (2E)-4-[2-([(2S)-1-[(2R)-2-(acetylamino)pent-4-ynoyl]pyrrolidin-2-yl]carbonyl)-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
Mus musculus
-
in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.000198
ethyl (2E)-4-[2-([(2S)-1-[2-(acetylamino)-2-methylpropanoyl]pyrrolidin-2-yl]carbonyl)-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
Mus musculus
-
in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.000148
ethyl (2E)-4-[2-([(2S)-1-[2-(acetylamino)-3-methylbut-2-enoyl]pyrrolidin-2-yl]carbonyl)-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
Mus musculus
-
in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.001
ethyl (2E)-4-[2-([(2S)-1-[3-(acetylamino)benzoyl]pyrrolidin-2-yl]carbonyl)-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
Mus musculus
-
IC50 above 0.001 mM, in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.000267
ethyl (2E)-4-[2-([(2S)-1-[4-(acetylamino)benzoyl]pyrrolidin-2-yl]carbonyl)-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
Mus musculus
-
in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.000638
ethyl (2E)-4-[2-[[(2S)-1-[[(2R)-1-acetylpiperidin-2-yl]carbonyl]pyrrolidin-2-yl]carbonyl]-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
Mus musculus
-
in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.001
ethyl (2E)-4-[2-[[(2S)-1-[[(3S)-2-acetyl-1,2,3,4-tetrahydroisoquinolin-3-yl]carbonyl]pyrrolidin-2-yl]carbonyl]-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
Mus musculus
-
IC50 above 0.001 mM, in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.000167
ethyl (2E)-4-[2-[[(2S)-1-[[(4S)-3-acetyl-1,3-thiazolidin-4-yl]carbonyl]pyrrolidin-2-yl]carbonyl]-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
Mus musculus
-
in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.0000093
ethyl (2E)-4-[2-[[(2S)-1-[[1-(acetylamino)cyclopropyl]carbonyl]pyrrolidin-2-yl]carbonyl]-1-(2-amino-2-oxoethyl)hydrazinyl]-4-oxobut-2-enoate
Mus musculus
-
in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.0093
ethyl (2S,3S)-3-[[1-(2-amino-2-oxoethyl)-2-[([2S)-1-(2-oxopropanoyl)pyrrolidin-2-yl]carbonyl]hydrazinyl]carbonyl]oxirane-2-carboxylate
Mus musculus
-
IC50 above 0.001 mM, in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.0081
ethyl (2S,3S)-3-[[2-([(2S)-1-[(2R)-2-(acetylamino)butanoyl]pyrrolidin-2-yl]carbonyl)-1-(2-amino-2-oxoethyl)hydrazinyl]carbonyl]oxirane-2-carboxylate
Mus musculus
-
IC50 above 0.001 mM, in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.0086
ethyl (2S,3S)-3-[[2-([(2S)-1-[(2R)-2-(acetylamino)pent-4-ynoyl]pyrrolidin-2-yl]carbonyl)-1-(2-amino-2-oxoethyl)hydrazinyl]carbonyl]oxirane-2-carboxylate
Mus musculus
-
IC50 above 0.001 mM, in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.0000115
ethyl (2S,3S)-3-[[2-[[(2S)-1-acetylpyrrolidin-2-yl]carbonyl]-1-(2-amino-2-oxoethyl)hydrazinyl]carbonyl]oxirane-2-carboxylate
Mus musculus
-
pH 7.4
0.0044
ethyl (2S,3S)-3-[[2-[[(2S)-1-[[1-(acetylamino)cyclopropyl]carbonyl]pyrrolidin-2-yl]carbonyl]-1-(2-amino-2-oxoethyl)hydrazinyl]carbonyl]oxirane-2-carboxylate
Mus musculus
-
IC50 above 0.001 mM, in 0.1 M citrate-phosphate, 4 mM dithiothreitol, pH 5.8, at 25°C
0.02 - 0.2
FaCPI-1
-
0.038 - 0.12
HvCPI-4
-
0.018 - 0.068
HvCPI-4-deltaT143-Cterm
-
0.022 - 0.091
HvCPI-4-deltaT151-Cterm
-
0.033 - 0.11
HvCPI-4-Q86P
-
0.000065 - 0.000103
Mu-Ala-Ala-azaAsn-CH=CH-CO-tetrahydroisoquinoline
0.0000033 - 0.000045
Mu-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
0.00145
Mu-Ala-Ala-azaAsn-CH=CH-CONHCH2CH2CH2Ph
Schistosoma mansoni
-
pH 6.8, 25°C
0.00000023 - 0.000101
Mu-Ala-Ala-azaAsn-CH=CH-COOEt
0.0000017 - 0.00009
Mu-Ala-Ala-azaAsn-EP(S,S)-CON(Bzl)2
0.000006 - 0.00006
Mu-Ala-Ala-azaAsn-EP(S,S)-CONHCH2-1-naphthyl
0.0006 - 0.00075
Mu-Ala-azaAsn-CH=CH-CO-tetrahydroisoquinoline
0.000006
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(2',4'-dichloro[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000035
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(2'-chloro[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000593
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(2,4-dichlorobenzene-1-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000169
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(3',4'-dichloro[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000023
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(3',4'-difluoro[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000033 - 0.000047
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(3'-fluoro[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
0.000045 - 0.000067
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(4'-chloro[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
0.000033
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(4'-cyano[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000071
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(4'-ethyl[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000006
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(4'-methoxy[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000032
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(4'-methyl[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000071
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(4'-tert-butyl[1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000282
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(4-bromobenzene-1-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000073
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(4-chlorobenzene-1-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000269
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-(4-fluorobenzene-1-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000012
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-([1,1'-biphenyl]-4-sulfonyl)-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000093
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-[2'-(trifluoromethyl)[1,1'-biphenyl]-4-sulfonyl]-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000005
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-[4'-(propan-2-yl)[1,1'-biphenyl]-4-sulfonyl]-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000121
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-[4'-(trifluoromethyl)[1,1'-biphenyl]-4-sulfonyl]-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000073 - 0.000969
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-[4'-[(propan-2-yl)oxy][1,1'-biphenyl]-4-sulfonyl]-L-prolinamide
0.000049
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-[4-(2H-1,3-benzodioxol-5-yl)benzene-1-sulfonyl]-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000332
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-[4-(trifluoromethyl)benzene-1-sulfonyl]-L-prolinamide
Homo sapiens
pH and temperature not specified in the publication
0.003889
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-(ethanesulfonyl)-N2-[(3'-fluoro[1,1'-biphenyl]-4-yl)methyl]-L-alaninamide
Homo sapiens
pH 7.4, 37°C
0.005854
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-(methanesulfonyl)-N2-[(3'-methoxy[1,1'-biphenyl]-4-yl)methyl]-D-alaninamide
Homo sapiens
pH 7.4, 37°C
0.000378
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-(methanesulfonyl)-N2-[(3'-methoxy[1,1'-biphenyl]-4-yl)methyl]-L-alaninamide
Homo sapiens
pH 7.4, 37°C
0.00505
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-(methanesulfonyl)-N2-[(3'-propoxy[1,1'-biphenyl]-4-yl)methyl]-D-alaninamide
Homo sapiens
pH 7.4, 37°C
0.000882
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-(methanesulfonyl)-N2-[(3'-propoxy[1,1'-biphenyl]-4-yl)methyl]-L-alaninamide
Homo sapiens
pH 7.4, 37°C
0.000601
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-(methanesulfonyl)-N2-[[3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methyl]-L-alaninamide
Homo sapiens
pH 7.4, 37°C
0.001818
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(2',3'-difluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(2-methylpropane-1-sulfonyl)-L-alaninamide
Homo sapiens
pH 7.4, 37°C
0.001086
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(2',3'-difluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(ethanesulfonyl)-L-alaninamide
Homo sapiens
pH 7.4, 37°C
0.001459
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(2',3'-difluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-D-alaninamide
Homo sapiens
pH 7.4, 37°C
0.007749
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(2',3'-difluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-L-norvalinamide
Homo sapiens
pH 7.4, 37°C
0.006745
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(2',3'-difluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(propane-1-sulfonyl)-L-alaninamide
Homo sapiens
pH 7.4, 37°C
0.000356
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(2'-fluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-L-alaninamide
Homo sapiens
pH 7.4, 37°C
0.006296
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(3',4'-difluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-D-alaninamide
Homo sapiens
pH 7.4, 37°C
0.000252
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(3',4'-difluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-L-alaninamide
Homo sapiens
pH 7.4, 37°C
0.001359 - 0.009249
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(3',5'-difluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-D-alaninamide
0.000425
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(3'-chloro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)alaninamide
Homo sapiens
pH 7.4, 37°C
0.000586
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(3'-ethoxy[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-L-alaninamide
Homo sapiens
pH 7.4, 37°C
0.002272
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(3'-fluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(2-methylpropane-1-sulfonyl)-L-alaninamide
Homo sapiens
pH 7.4, 37°C
0.002259
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(3'-fluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-D-alaninamide
Homo sapiens
pH 7.4, 37°C
0.000128
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(3'-fluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-L-alaninamide
Homo sapiens
pH 7.4, 37°C
0.004384
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(3'-fluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-L-norvalinamide
Homo sapiens
pH 7.4, 37°C
0.000323 - 0.001035
N-[(1S)-3-amino-1-cyano-3-oxopropyl]-N2-[(4'-fluoro[1,1'-biphenyl]-4-yl)methyl]-N2-(methanesulfonyl)-L-alaninamide
0.008
N-[(2S)-1-{2-(2-amino-2-oxoethyl)-2-[(2E,4E)-hexa-2,4-dienoyl]hydrazinyl}-1-oxopropan-2-yl]-N2-[(benzyloxy)carbonyl]-L-alaninamide
Trichomonas vaginalis
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.0000045 - 0.0003
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(1,3-dihydroisoindol-2-ylcarbonyl)propenoyl)hydrazine
0.0005 - 0.001
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(1-piperidylcarbonyl)propenoyl)hydrazine
0.000018 - 0.00007
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(2,3-dihydroindol-1-ylcarbonyl)propenoyl)hydrazine
0.0075
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(2-furyl)propenoyl)hydrazine
Ixodes ricinus
-
0.1 M citrate phosphate, 4 mM dithiothreitol, pH 5.5, 0.1 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.0000025 - 0.0002
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(3,4-dihydro-1H-quinolin-2-ylcarbonyl)propenoyl)hydrazine
0.0000035 - 0.00007
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(3,4-dihydro-2H-quinolin-1-ylcarbonyl)propenoyl)hydrazine
0.008 - 0.01
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(3-pyridyl)propenoyl)hydrazine
Trichomonas vaginalis
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.000075 - 0.0008
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(4-fluorobenzyl)carbamoylpropenoyl)hydrazine
0.00001 - 0.00075
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(4-phenyl-5,6-dihydro-2H-pyridin-1-ylcarbonyl)propenoyl)hydrazine
0.0000055 - 0.000035
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(methyl-1-naphthylmethylcarbamoyl)propenoyl)hydrazine
0.00005 - 0.0006
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(methylphenethylcarbamoyl)propenoyl)hydrazine
0.0000018 - 0.00006
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-(methylphenylcarbamoyl)propenoyl)hydrazine
0.00001 - 0.001
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-benzylcarbamoylpropenoyl)hydrazine
0.00000055 - 0.000055
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-benzylmethylcarbamoylpropenoyl)hydrazine
0.0009 - 0.015
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-bis-(2-furylmethyl)carbamoylpropenoyl)hydrazine
0.0000023 - 0.00045
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-dibenzylcarbamoylpropenoyl)hydrazine
0.0001 - 0.001
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-dibutylcarbamoylpropenoyl)hydrazine
0.002 - 0.0027
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-diethylcarbamoylpropenoyl)hydrazine
0.0000045 - 0.000031
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-ethoxycarbonylpropenoyl)hydrazine
0.00001 - 0.0006
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-phenethylcarbamoylpropenoyl)hydrazine
0.00007
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-phenylbenzylcarbamoylpropenoyl)hydrazine
Schistosoma mansoni
-
in 0.1 M citrate phosphate, 4 mM dithiothreitol, pH 6.8, 0.01 mM Cbz-Ala-Ala-Asn-7-amido-4-methylcoumarin as substrate
0.00001 - 0.0007
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-phenylcarbamoylpropenoyl)hydrazine
0.00008 - 0.00075
N2-(N-benzyloxycarbonylalanylalanyl)-N1-carbamoylmethyl-N1-trans-3-(N-methyl-N-(1-(N-methyl-N-phenethylcarbamoyl)phenylethyl)carbamoylpropenoyl)hydrazine
0.00006 - 0.0007
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyl(4-fluorobenzyl)carbamoylpropenoyl)-N1-carbamoylmethylhydrazine
0.000006 - 0.000062
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyl-1-naphthylmethylcarbamoylpropenoyl)-N1-carbamoylmethylhydrazine
0.000006 - 0.00007
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyl-2-naphthylmethylcarbamoylpropenoyl)-N1-carbamoylmethylhydrazine
0.000005 - 0.000038
N2-(N-benzyloxycarbonylalanylalanyl)-N1-trans-(3-benzyloxycarbonylpropenoyl)-N1-carbamoylmethylhydrazine
0.0000028 - 0.00001
N2-(N-biotinylalanylalanyl)-N1-carbamoylmethyl-N1-trans-(3-ethoxycarbonylpropenoyl)hydrazine
0.0000024 - 0.0001
Pip-Ala-Ala-azaAsn-CH=CH-CON(Bzl)-CH2-1-naphthyl
0.000017 - 0.00008
Pip-Ala-Ala-azaAsn-CH=CH-CON(Bzl)2
0.000008 - 0.000057
Pip-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
0.0004 - 0.00075
Pip-Ala-Ala-azaAsn-CH=CH-CONHCH2CH2Ph
0.000015 - 0.00008
Pip-Ala-Ala-azaAsn-CH=CH-COOEt
0.000012 - 0.000072
Pip-Ala-Ala-azaAsn-EP(S,S)-CON(Bzl)2
0.0000085 - 0.00016
Pip-Ala-Ala-azaAsn-EP(S,S)-CONHCH2-1-naphthyl
0.00003 - 0.00022
Pip-Ala-Ala-azaAsn-EP(S,S)-COOEt
0.00015 - 0.0006
Pip-Ala-azaAsn-CH=CH-CO-tetrahydroisoquinoline
0.000031 - 0.00009
Piz-Ala-Ala-azaAsn-CH=CH-CON(Bzl)2
0.0000026 - 0.00007
Piz-Ala-Ala-azaAsn-CH=CH-CON(CH2-1-naphthyl)2
0.0000038 - 0.00004
Piz-Ala-Ala-azaAsn-CH=CH-CON(CH3)CH2-1-naphthyl
0.000013 - 0.00025
Piz-Ala-Ala-azaAsn-CH=CH-COOBzl
0.0000085 - 0.0003
Piz-Ala-Ala-azaAsn-CH=CH-COOEt
0.000011 - 0.00015
Piz-Ala-Ala-azaAsn-EP(S,S)-CON(Bzl)2
0.001
[(2S)-1-[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]-3-[4-hydroxy-3-[hydroxy(oxo)ammonio]phenyl]-1-oxopropan-2-yl]carbamate
Homo sapiens
-
pH 5.8, temperature not specified in the publication
0.000141
[(2Z)-1-[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]-1-oxobut-2-en-2-yl]carbamic acid
Homo sapiens
-
pH 5.8, temperature not specified in the publication
0.0000065
[1-[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]-1-oxobutan-2-yl]carbamic acid
Homo sapiens
-
pH 5.8, temperature not specified in the publication
0.000017
[1-[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]-1-oxopent-4-yn-2-yl]carbamic acid
Homo sapiens
-
pH 5.8, temperature not specified in the publication
0.000198
[1-[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]-2-methyl-1-oxopropan-2-yl]carbamic acid
Homo sapiens
-
pH 5.8, temperature not specified in the publication
0.000148
[1-[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]-3-methyl-1-oxobut-2-en-2-yl]carbamic acid
Homo sapiens
-
pH 5.8, temperature not specified in the publication
0.0000081
[1-[(2S)-2-[[2-(2-amino-2-oxoethyl)-2-[[(2R,3R)-3-(ethoxycarbonyl)oxiran-2-yl]carbonyl]hydrazinyl]carbonyl]pyrrolidin-1-yl]-1-oxobutan-2-yl]carbamic acid
Homo sapiens
-
pH 5.8, temperature not specified in the publication
additional information
additional information
-