3.4.22.34: Legumain

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For detailed information about Legumain, go to the full flat file.

Reaction

hydrolysis of proteins and small molecule substrates at -Asn-/-Xaa- bonds =

Synonyms

AEP, Antigen Sj32, Antigen SM32, As-specific vacuolar cysteine proteinase, Asn-specific vacuolar cysteine proteinase, asparagine endopeptidase, asparaginly endopeptidase, asparaginyl endopepidase, Asparaginyl endopeptidase, asparaginyl endopeptidase legumain, asparaginyl endopeptidase,, asparaginyl proteinase, asparaginyl-specific cysteine endopeptidase, asparagyl-endopeptidase, aspartate-specific endopeptidase, AtLEGgamma, Bean endopeptidase, C197 legumain, c197 Sm32, cysteine protease 1, hemoglobinase, HlLgm, HlLgm2, IrAE, IrAE protein, isae1, isae2, LeG, LEG-1, Leg-2, Leg-4, Leg1, Leg2, Leg3, Leg4, Leg5, legumain, legumain-1, LGMN, lysosomal asparaginycysteine endopeptidase, lysosomal asparaginyl endopeptidase, lysosomal cysteine proteinase, More, N197 legumain, osteoclast inhibitory peptide 2, Ov-aep-1, Phaseolin, Proteinase B, PrVPE1, schistosome legumain, Sj32, Sm32, SmAE, SmAE protein, SPAE, TcLEG3, TcLEG6, TcLEG9, TvAE1, vacuolar processing enzyme, vacuolar processing enzyme 1a, vacuolar processing enzyme 1b, vacuolar processing enzyme 2, vacuolar processing enzyme 3, Vicilin peptidohydrolase, VPE, VPE1a, VPE1b, VPE2, VPE3

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.34 Legumain

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Results	in table
22	Activating Compound
1004	AA Sequence
6	Application
1	CAS Registry Number
49	Cloned(Commentary)
3	Crystallization (Commentary)
1114	Disease/ Diagnostics
17	Expression
14	General Information
10	General Stability
266	IC50 Value
466	Inhibitors
47	Ki Value [mM]
15	KM Value [mM]
70	Localization
1	Metals/Ions
58	Molecular Weight [Da]
77	Natural Substrates/ Products (Substrates)
124	Organism
61	PDB ID
53	pH Optimum
13	pH Range
7	pH Stability
2	pI Value
48	Posttranslational Modification
16	Protein Variants
39	Purification (Commentary)
7	Reaction
34	Reaction Type
123	Reference
1	Renatured (Commentary)
167	Source Tissue
49	Specific Activity [micromol/min/mg]
3	Storage Stability
324	Substrates and Products (Substrate)
30	Subunits
197	Synonyms
28	Temperature Optimum [°C]
2	Temperature Range [°C]
5	Temperature Stability [°C]
5	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.4.22.34 - Legumain

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

sitting-drop vapor-diffusion method

Arabidopsis thaliana

Q39119

755030

-

Homo sapiens

-

668775

super-activated legumain is crystallized in complex with the legumain-specific inhibitor Ala-Ala-Asn-chloromethylketone to resolution of 2.47 A

Homo sapiens

Q99538

717046