Disease on EC 3.4.22.34 - Legumain
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Acidosis
Activation of asparaginyl endopeptidase leads to Tau hyperphosphorylation in Alzheimer disease.
Acidosis
Animal models of the sporadic form of Alzheimer's disease: focus on the disease and not just the lesions.
Acidosis
Mechanism of Tau Hyperphosphorylation Involving Lysosomal Enzyme Asparagine Endopeptidase in a Mouse Model of Brain Ischemia.
Acute Coronary Syndrome
Legumain in Acute Coronary Syndromes: A Substudy of the PLATO (Platelet Inhibition and Patient Outcomes) Trial.
Adenocarcinoma
Asparaginyl endopeptidase enhances pancreatic ductal adenocarcinoma cell invasion in an exosome-dependent manner and correlates with poor prognosis.
Adenocarcinoma of Lung
Immunohistochemical distributions of cathepsin B and basement membrane antigens in human lung adenocarcinoma: association with invasion and metastasis.
Alzheimer Disease
Activation of asparaginyl endopeptidase leads to Tau hyperphosphorylation in Alzheimer disease.
Alzheimer Disease
Animal models of the sporadic form of Alzheimer's disease: focus on the disease and not just the lesions.
Alzheimer Disease
Asparagine Endopeptidase (? Secretase), an Enzyme Implicated in Alzheimer's Disease Pathology, Is an Inhibitor of Axon Regeneration in Peripheral Nerves.
Alzheimer Disease
Cerebrospinal fluid tau fragment correlates with tau PET: a candidate biomarker for tangle pathology.
Alzheimer Disease
Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.
Alzheimer Disease
Cuprizone and EAE mouse frontal cortex proteomics revealed proteins altered in multiple sclerosis.
Alzheimer Disease
Delta- and beta- secretases crosstalk amplifies the amyloidogenic pathway in Alzheimer's disease.
Alzheimer Disease
Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease.
Alzheimer Disease
Imaging asparaginyl endopeptidase (AEP) in the live brain as a biomarker for Alzheimer's disease.
Alzheimer Disease
Increased cross-linking micelle retention in the brain of Alzheimer's disease mice by elevated asparagine endopeptidase protease responsive aggregation.
Alzheimer Disease
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Alzheimer Disease
Involvement of Activation of Asparaginyl Endopeptidase in Tau Hyperphosphorylation in Repetitive Mild Traumatic Brain Injury.
Alzheimer Disease
Lack of association between LGMN and Alzheimer's disease in the Southern Han Chinese population.
Alzheimer Disease
Structural and functional analysis of cystatin E reveals enzymologically relevant dimer and amyloid fibril states.
Anaphylaxis
A case of severe anaphylaxis to kidney bean: phaseolin (vicilin) and PHA (lectin) identified as putative allergens.
Atherosclerosis
Expression of the cysteine protease legumain in vascular lesions and functional implications in atherogenesis.
Atherosclerosis
Increased Legumain/Smad3 expression in atherosclerotic plaque of rat thoracic aorta.
Atherosclerosis
Increased levels of legumain in plasma and plaques from patients with carotid atherosclerosis.
Atherosclerosis
Legumain acts on neuroinflammatory to affect CUS-induced cognitive impairment.
Atherosclerosis
Legumain in Acute Coronary Syndromes: A Substudy of the PLATO (Platelet Inhibition and Patient Outcomes) Trial.
Atherosclerosis
Legumain suppresses OxLDL-induced macrophage apoptosis through enhancement of the autophagy pathway.
Atherosclerosis
Legumain/asparaginyl endopeptidase controls extracellular matrix remodeling through the degradation of fibronectin in mouse renal proximal tubular cells.
Atherosclerosis
Mammalian legumain - A lysosomal cysteine protease with extracellular functions?
Atherosclerosis
Synthesis and evaluation of aza-peptidyl inhibitors of the lysosomal asparaginyl endopeptidase, legumain.
Autoimmune Diseases
Autophagic activity measured in whole rat hepatocytes as the accumulation of a novel BHMT fragment (p10), generated in amphisomes by the asparaginyl proteinase, legumain.
Bone Resorption
Identification of human asparaginyl endopeptidase (legumain) as an inhibitor of osteoclast formation and bone resorption.
Bone Resorption
In vivo and in vitro evidence for the involvement of cysteine proteinases in bone resorption.
Bone Resorption
Osteoclast inhibitory peptide 2 inhibits osteoclast formation via its C-terminal fragment.
Bone Resorption
Proteome analysis of secreted proteins during osteoclast differentiation using two different methods: two-dimensional electrophoresis and isotope-coded affinity tags analysis with two-dimensional chromatography.
Brain Concussion
Involvement of Activation of Asparaginyl Endopeptidase in Tau Hyperphosphorylation in Repetitive Mild Traumatic Brain Injury.
Brain Ischemia
Activation of asparaginyl endopeptidase leads to Tau hyperphosphorylation in Alzheimer disease.
Brain Ischemia
Legumain knockout improved cognitive impairment via reducing neuroinflammation in right unilateral common carotid artery occlusion mice.
Brain Ischemia
Mechanism of Tau Hyperphosphorylation Involving Lysosomal Enzyme Asparagine Endopeptidase in a Mouse Model of Brain Ischemia.
Brain Neoplasms
Increased Gold Nanoparticle Retention in Brain Tumors by in Situ Enzyme-Induced Aggregation.
Breast Neoplasms
A Legumain-based minigene vaccine targets the tumor stroma and suppresses breast cancer growth and angiogenesis.
Breast Neoplasms
Accumulation of Memory Precursor CD8 T Cells in Regressing Tumors Following Combination Therapy with Vaccine and Anti-PD-1 Antibody.
Breast Neoplasms
Alginic acid-coated chitosan nanoparticles loaded with legumain DNA vaccine: effect against breast cancer in mice.
Breast Neoplasms
C/EBP?/AEP Signaling Regulates the Oxidative Stress in Malignant Cancers, Stimulating the Metastasis.
Breast Neoplasms
Development of a selected reaction monitoring mass spectrometry-based assay to detect asparaginyl endopeptidase activity in biological fluids.
Breast Neoplasms
Legumain is an independent predictor for invasive recurrence in breast ductal carcinoma in situ.
Breast Neoplasms
Legumain protein as a potential predictive biomarker for asian patients with breast carcinoma.
Breast Neoplasms
MiRNA-Embedded ShRNAs for Radiation-Inducible LGMN Knockdown and the Antitumor Effects on Breast Cancer.
Breast Neoplasms
Suppression of asparaginyl endopeptidase attenuates breast cancer-induced bone pain through inhibition of neurotrophin receptors.
Breast Neoplasms
Suppression of Asparaginyl Endopeptidase Inhibits Polyomavirus Middle T Antigen-Induced Tumor Formation and Metastasis.
Breast Neoplasms
TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities.
Bronchiectasis
Noncovalent complexes between the lysosomal proteinase cathepsin B and its propeptide account for stable, extracellular, high molecular mass forms of the enzyme.
Carcinogenesis
Asparaginyl endopeptidase improves the resistance of microtubule-targeting drugs in gastric cancer through IQGAP1 modulating the EGFR/JNK/ERK signaling pathway.
Carcinogenesis
Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain.
Carcinogenesis
Expression of legumain correlates with prognosis and metastasis in gastric carcinoma.
Carcinogenesis
Functional imaging of legumain in cancer using a new quenched activity-based probe.
Carcinogenesis
Molecular-dynamics-simulation-driven design of a protease-responsive probe for in-vivo tumor imaging.
Carcinogenesis
Peptide-based MRI contrast agent and near-infrared fluorescent probe for intratumoral legumain detection.
Carcinoma
A Novel Antitumor Prodrug Platform Designed to Be Cleaved by the Endoprotease Legumain.
Carcinoma
Asparaginyl endopeptidase enhances pancreatic ductal adenocarcinoma cell invasion in an exosome-dependent manner and correlates with poor prognosis.
Carcinoma
Expression of legumain correlates with prognosis and metastasis in gastric carcinoma.
Carcinoma
Latency of cathepsin B secreted by human colon carcinoma cells is not linked to secretion of cystatin C and is relieved by neutrophil elastase.
Carcinoma
Legumain expression in relation to clinicopathologic and biological variables in colorectal cancer.
Carcinoma
Modulation of invasive properties of murine squamous carcinoma cells by heterologous expression of cathepsin B and cystatin C.
Carcinoma
Overexpression of asparaginyl endopeptidase is significant for esophageal carcinoma metastasis and predicts poor patient prognosis.
Carcinoma, Ductal
Legumain is an independent predictor for invasive recurrence in breast ductal carcinoma in situ.
Carcinoma, Hepatocellular
Proteolytic processing and glycosylation of cathepsin B. The role of the primary structure of the latent precursor and of the carbohydrate moiety for cell-type-specific molecular forms of the enzyme.
Carcinoma, Intraductal, Noninfiltrating
Legumain is an independent predictor for invasive recurrence in breast ductal carcinoma in situ.
Carcinoma, Ovarian Epithelial
The expression of asparaginyl endopeptidase promotes growth potential in epithelial ovarian cancer.
Carcinoma, Squamous Cell
Invasive properties of murine squamous carcinoma cells: secretion of matrix-degrading cathepsins is attributable to a deficiency in the mannose 6-phosphate/insulin-like growth factor II receptor.
Cardiovascular Diseases
Associations of Interleukin 10, Matrix Metallopeptidase 9, and Legumain with Blood Pressure Variability and Neurologic Outcomes in Patients with Ischemic Stroke.
Cardiovascular Diseases
Legumain in Acute Coronary Syndromes: A Substudy of the PLATO (Platelet Inhibition and Patient Outcomes) Trial.
Cardiovascular Diseases
Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages.
Carotid Artery Diseases
Increased levels of legumain in plasma and plaques from patients with carotid atherosclerosis.
Carotid Artery Diseases
Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages.
Carotid Stenosis
Increased levels of legumain in plasma and plaques from patients with carotid atherosclerosis.
Chronic Periodontitis
Cathepsin B in gingival crevicular fluid of adult periodontitis patients: identification by immunological and enzymological methods.
Clonorchiasis
Identification of a serodiagnostic antigen, legumain, by immunoproteomic analysis of excretory-secretory products of Clonorchis sinensis adult worms.
Colorectal Neoplasms
Effects of legumain as a potential prognostic factor on gastric cancers.
Colorectal Neoplasms
High expression of the cysteine proteinase legumain in colorectal cancer - implications for therapeutic targeting.
Colorectal Neoplasms
Legumain expression in relation to clinicopathologic and biological variables in colorectal cancer.
Colorectal Neoplasms
Legumain: a biomarker for diagnosis and prognosis of human ovarian cancer.
Colorectal Neoplasms
Synthesis of a novel legumain-cleavable colchicine prodrug with cell-specific toxicity.
Coronary Artery Disease
High Plasma Levels of Legumain in Patients with Complex Coronary Lesions.
Cystic Fibrosis
Activity of the lysosomal cysteine proteinases (cathepsin B,H,L) and a metalloproteinase (MMP-7-ase) in the serum of cystic fibrosis homozygous children.
Dementia
Development of a selected reaction monitoring mass spectrometry-based assay to detect asparaginyl endopeptidase activity in biological fluids.
Demyelinating Diseases
Exploring the factors underlying remyelination arrest by studying the post-transcriptional regulatory mechanisms of cystatin F gene.
Demyelinating Diseases
Microglial cystatin F expression is a sensitive indicator for ongoing demyelination with concurrent remyelination.
Diabetes Mellitus, Type 2
Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages.
Esophageal Neoplasms
Overexpression of asparaginyl endopeptidase is significant for esophageal carcinoma metastasis and predicts poor patient prognosis.
Food Hypersensitivity
Occupational food allergy due to parvalbumin and phaseolin induced by epicutaneous sensitization.
Ganglioneuroblastoma
Legumain correlates with neuroblastoma differentiation and can be used in prodrug design.
Glioblastoma
Inactivation of Wild-Type p53 by Asparagine Endopeptidase in Glioblastoma: An Opportunity to Target the "Undruggable".
Glioblastoma
Role of asparagine endopeptidase in mediating wild-type p53 inactivation of glioblastoma.
Glioma
Aggregable Nanoparticles-Enabled Chemotherapy and Autophagy Inhibition Combined with Anti-PD-L1 Antibody for Improved Glioma Treatment.
Glioma
Inhibition of cathepsin L sensitizes human glioma cells to ionizing radiation in vitro through NF-?B signaling pathway.
Heart Rupture
Legumain is a predictor of all-cause mortality and potential therapeutic target in acute myocardial infarction.
Hookworm Infections
An enzymatically inactivated hemoglobinase from Necator americanus induces neutralizing antibodies against multiple hookworm species and protects dogs against heterologous hookworm infection.
Hookworm Infections
Neutralizing antibodies to the hookworm hemoglobinase Na-APR-1: implications for a multivalent vaccine against hookworm infection and schistosomiasis.
Hookworm Infections
Vaccination with recombinant aspartic hemoglobinase reduces parasite load and blood loss after hookworm infection in dogs.
Hypercalcemia
Identification of human asparaginyl endopeptidase (legumain) as an inhibitor of osteoclast formation and bone resorption.
Hyperglycemia
Activation of asparaginyl endopeptidase leads to Tau hyperphosphorylation in Alzheimer disease.
Hypersensitivity
Phaseolin: a 47.5kDa protein of red kidney bean (Phaseolus vulgaris L.) plays a pivotal role in hypersensitivity induction.
Hypertension, Pulmonary
Macrophage-Derived Legumain Promotes Pulmonary Hypertension by Activating the MMP (Matrix Metalloproteinase)-2/TGF (Transforming Growth Factor)-?1 Signaling.
Infections
Asparagine Endopeptidase Controls Anti-Influenza Virus Immune Responses through TLR7 Activation.
Infections
Asparaginyl endopeptidase from the carcinogenic liver fluke, Opisthorchis viverrini, and its potential for serodiagnosis.
Infections
Cathepsin B-Deficient Mice Resolve Leishmania major Inflammation Faster in a T Cell-Dependent Manner.
Infections
The C-terminal extension of Leishmania pifanoi amastigote-specific cysteine proteinase Lpcys2: A putative function in macrophage infection.
Ischemic Stroke
Associations of Interleukin 10, Matrix Metallopeptidase 9, and Legumain with Blood Pressure Variability and Neurologic Outcomes in Patients with Ischemic Stroke.
Ischemic Stroke
Legumain Knockout Protects Against A?1-42-Induced AD-like Cognitive Deficits and Synaptic Plasticity Dysfunction Via Inhibiting Neuroinflammation Without Cleaving APP.
legumain deficiency
Genomic Analysis of Storage Protein Deficiency in Genetically Related Lines of Common Bean (Phaseolus vulgaris).
legumain deficiency
Legumain promotes fibrogenesis in chronic pancreatitis via activation of transforming growth factor ?1.
legumain deficiency
Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI.
legumain deficiency
Legumain suppresses OxLDL-induced macrophage apoptosis through enhancement of the autophagy pathway.
Leukemia
RAC2, AEP, and ICAM1 expression are associated with CNS disease in a mouse model of pre-B childhood acute lymphoblastic leukemia.
Liver Cirrhosis
Asparaginyl endopeptidase may promote liver sinusoidal endothelial cell angiogenesis via PI3K/Akt pathway.
Liver Cirrhosis
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
Lymphatic Metastasis
Legumain expression in relation to clinicopathologic and biological variables in colorectal cancer.
Lymphohistiocytosis, Hemophagocytic
Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome.
Lymphoma
M2 tumour-associated macrophages contribute to tumour progression via legumain remodelling the extracellular matrix in diffuse large B cell lymphoma.
Lymphoma, B-Cell
M2 tumour-associated macrophages contribute to tumour progression via legumain remodelling the extracellular matrix in diffuse large B cell lymphoma.
Lymphoma, Large B-Cell, Diffuse
M2 tumour-associated macrophages contribute to tumour progression via legumain remodelling the extracellular matrix in diffuse large B cell lymphoma.
Malaria
Cloning and characterization of Plasmodium falciparum cysteine protease, falcipain-2B.
Malaria
Design, synthesis and biological evaluation of functionalized phthalimides: A new class of antimalarials and inhibitors of falcipain-2, a major hemoglobinase of malaria parasite.
Malaria
Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum: a catabolic pathway initiated by a specific aspartic protease.
Malaria
High-level expression of Falcipain-2 in Escherichia coli by codon optimization and auto-induction.
Malaria
Oxidation and Tyrosine Nitration Induce Structural Changes and Inhibits Plasmodium falciparum Falcipain-2 Activity In Vitro.
Malaria
Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease.
Malaria
Synthesis and molecular modeling studies of derivatives of a highly potent peptidomimetic vinyl ester as falcipain-2 inhibitors.
Melanoma
Contact of high-invasive, but not low-invasive, melanoma cells to native collagen I induces the release of mature cathepsin B.
Melanoma
Fabrication of chitosan based nanocomposite with legumain sensitive properties using charge driven self-assembly strategy.
Melanoma
Low-level internalization of cystatin E/M affects legumain activity and migration of melanoma cells.
Mouth Neoplasms
Legumain Induces Oral Cancer Pain by Biased Agonism of Protease-Activated Receptor-2.
Mouth Neoplasms
Silencing of cystatin M in metastatic oral cancer cell line MDA-686Ln by siRNA increases cysteine proteinases and legumain activities, cell proliferation and in vitro invasion.
Multiple Sclerosis
Cuprizone and EAE mouse frontal cortex proteomics revealed proteins altered in multiple sclerosis.
Myocardial Infarction
Legumain in Acute Coronary Syndromes: A Substudy of the PLATO (Platelet Inhibition and Patient Outcomes) Trial.
Myocardial Infarction
Legumain is a predictor of all-cause mortality and potential therapeutic target in acute myocardial infarction.
Myotoxicity
Simvastatin inhibits glucose metabolism and legumain activity in human myotubes.
Neoplasm Metastasis
A Novel Antitumor Prodrug Platform Designed to Be Cleaved by the Endoprotease Legumain.
Neoplasm Metastasis
Asparaginyl endopeptidase induces endothelial permeability and tumor metastasis via downregulating zonula occludens protein ZO-1.
Neoplasm Metastasis
Asparaginyl endopeptidase promotes the invasion and metastasis of gastric cancer through modulating epithelial-to-mesenchymal transition and analysis of their phosphorylation signaling pathways.
Neoplasm Metastasis
Autophagic activity measured in whole rat hepatocytes as the accumulation of a novel BHMT fragment (p10), generated in amphisomes by the asparaginyl proteinase, legumain.
Neoplasm Metastasis
C/EBP?/AEP Signaling Regulates the Oxidative Stress in Malignant Cancers, Stimulating the Metastasis.
Neoplasm Metastasis
Cystatin C properties crucial for uptake and inhibition of intracellular target enzymes.
Neoplasm Metastasis
Effect of protein kinase modulators on the regulation of cathepsin B activity in THP-1 human monocytic leukemia cells.
Neoplasm Metastasis
Effects of legumain as a potential prognostic factor on gastric cancers.
Neoplasm Metastasis
Esomeprazole inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis.
Neoplasm Metastasis
Evaluation of the anti-cervical cancer effect of a prodrug ?CBZ-AAN-DOX with hypoxic cell culture and tumor-bearing zebrafish models.
Neoplasm Metastasis
Expression of both poly r(C) binding protein 1 (PCBP1) and miRNA-3978 is suppressed in peritoneal gastric cancer metastasis.
Neoplasm Metastasis
Expression of legumain correlates with prognosis and metastasis in gastric carcinoma.
Neoplasm Metastasis
Functional Role of Asparaginyl Endopeptidase Ubiquitination by TRAF6 in Tumor Invasion and Metastasis.
Neoplasm Metastasis
High Level of Legumain Was Correlated With Worse Prognosis and Peritoneal Metastasis in Gastric Cancer Patients.
Neoplasm Metastasis
Legumain expression in relation to clinicopathologic and biological variables in colorectal cancer.
Neoplasm Metastasis
Legumain is a predictive effector of peritoneal metastasis for diffuse gastric cancer patients.
Neoplasm Metastasis
MiRNA-3978 regulates peritoneal gastric cancer metastasis by targeting legumain.
Neoplasm Metastasis
Modulation of invasive properties of murine squamous carcinoma cells by heterologous expression of cathepsin B and cystatin C.
Neoplasm Metastasis
Overexpression of asparaginyl endopeptidase is significant for esophageal carcinoma metastasis and predicts poor patient prognosis.
Neoplasm Metastasis
Overexpression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy.
Neoplasm Metastasis
Radiofluorinated Smart Probes for Noninvasive PET Imaging of Legumain Activity in Living Subjects.
Neoplasm Metastasis
Regulation of cathepsin B activity by modulators of arachidonic acid metabolism in human monocytes.
Neoplasm Metastasis
Suppression of asparaginyl endopeptidase attenuates breast cancer-induced bone pain through inhibition of neurotrophin receptors.
Neoplasm Metastasis
Suppression of Asparaginyl Endopeptidase Inhibits Polyomavirus Middle T Antigen-Induced Tumor Formation and Metastasis.
Neoplasm Metastasis
Synthesis and evaluation of radioactive/fluorescent peptide probes for imaging of legumain activity.
Neoplasm Metastasis
The legumain protease-activated auristatin prodrugs suppress tumor growth and metastasis without toxicity.
Neoplasms
A Legumain-based minigene vaccine targets the tumor stroma and suppresses breast cancer growth and angiogenesis.
Neoplasms
A new tandem peptide modified liposomal doxorubicin for tumor "ecological therapy".
Neoplasms
A Novel Antitumor Prodrug Platform Designed to Be Cleaved by the Endoprotease Legumain.
Neoplasms
A novel legumain protease-activated micelle cargo enhances anticancer activity and cellular internalization of doxorubicin.
Neoplasms
A possible mechanism for the long-lasting antitumor effect of the macromolecular conjugate DE-310: mediation by cellular uptake and drug release of its active camptothecin analog DX-8951.
Neoplasms
A protease-responsive fluorescent probe for sensitive imaging of legumain activity in living tumor cells.
Neoplasms
A synthetic enzyme inhibitor is a novel targeting ligand for nanotherapeutic drug delivery inhibiting primary tumor growth without systemic toxicity.
Neoplasms
Activation of legumain involves proteolytic and conformational events, resulting in a context- and substrate-dependent activity profile.
Neoplasms
Antibody-Prodrug Conjugates with KSP Inhibitors and Legumain-Mediated Metabolite Formation.
Neoplasms
Asparaginyl endopeptidase enhances pancreatic ductal adenocarcinoma cell invasion in an exosome-dependent manner and correlates with poor prognosis.
Neoplasms
Asparaginyl endopeptidase induces endothelial permeability and tumor metastasis via downregulating zonula occludens protein ZO-1.
Neoplasms
Asparaginyl endopeptidase may promote liver sinusoidal endothelial cell angiogenesis via PI3K/Akt pathway.
Neoplasms
Asparaginyl endopeptidase promotes proliferation and invasiveness of prostate cancer cells via PI3K/AKT signaling pathway.
Neoplasms
Association of legumain expression pattern with prostate cancer invasiveness and aggressiveness.
Neoplasms
Autophagic activity measured in whole rat hepatocytes as the accumulation of a novel BHMT fragment (p10), generated in amphisomes by the asparaginyl proteinase, legumain.
Neoplasms
Bioengineered Macrophages Can Responsively Transform into Nanovesicles To Target Lung Metastasis.
Neoplasms
C/EBP?/AEP Signaling Regulates the Oxidative Stress in Malignant Cancers, Stimulating the Metastasis.
Neoplasms
Cathepsin B expression in colorectal carcinomas correlates with tumor progression and shortened patient survival.
Neoplasms
Clinicopathologic significance of legumain overexpression in cancer: a systematic review and meta-analysis.
Neoplasms
Comparative localization of cathepsin B protein and activity in colorectal cancer.
Neoplasms
Cooperatively Responsive Peptide Nanotherapeutic that Regulates Angiopoietin Receptor Tie2 Activity in Tumor Microenvironment To Prevent Breast Tumor Relapse after Chemotherapy.
Neoplasms
Cystatin C properties crucial for uptake and inhibition of intracellular target enzymes.
Neoplasms
Determination of cathepsin B expression may offer additional prognostic information for ovarian cancer patients.
Neoplasms
Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain.
Neoplasms
Effect of protein kinase modulators on the regulation of cathepsin B activity in THP-1 human monocytic leukemia cells.
Neoplasms
Esomeprazole inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis.
Neoplasms
Evaluation of the anti-cervical cancer effect of a prodrug ?CBZ-AAN-DOX with hypoxic cell culture and tumor-bearing zebrafish models.
Neoplasms
Expression and protease activity of mouse legumain are regulated by the oncogene/transcription co-activator, DJ-1 through p53 and cleavage of annexin A2 is increased in DJ-1-knockout cells.
Neoplasms
Expression of legumain correlates with prognosis and metastasis in gastric carcinoma.
Neoplasms
Fabrication of chitosan based nanocomposite with legumain sensitive properties using charge driven self-assembly strategy.
Neoplasms
Functional imaging of legumain in cancer using a new quenched activity-based probe.
Neoplasms
Functional recombinant human Legumain protein expression in Pichia pastoris to enable screening for Legumain small molecule inhibitors.
Neoplasms
Functional Role of Asparaginyl Endopeptidase Ubiquitination by TRAF6 in Tumor Invasion and Metastasis.
Neoplasms
Genetically-engineered protein prodrug-like nanoconjugates for tumor-targeting biomimetic delivery via a SHEATH strategy.
Neoplasms
High expression of the cysteine proteinase legumain in colorectal cancer - implications for therapeutic targeting.
Neoplasms
High Level of Legumain Was Correlated With Worse Prognosis and Peritoneal Metastasis in Gastric Cancer Patients.
Neoplasms
IMD-0354 Targets Breast Cancer Stem Cells: A Novel Approach for an Adjuvant to Chemotherapy to Prevent Multidrug Resistance in a Murine Model.
Neoplasms
Inhibition of cathepsin L sensitizes human glioma cells to ionizing radiation in vitro through NF-?B signaling pathway.
Neoplasms
Intra- and extracellular regulation of activity and processing of legumain by cystatin E/M.
Neoplasms
Intracellular and extracellular cathepsin B facilitate invasion of MCF-10A neoT cells through reconstituted extracellular matrix in vitro.
Neoplasms
iRGD-Mediated and Enzyme-Induced Precise Targeting and Retention of Gold Nanoparticles for the Enhanced Imaging and Treatment of Breast Cancer.
Neoplasms
Knockdown of Legumain Suppresses Cervical Cancer Cell Migration and Invasion.
Neoplasms
Legumain correlates with neuroblastoma differentiation and can be used in prodrug design.
Neoplasms
Legumain expression in relation to clinicopathologic and biological variables in colorectal cancer.
Neoplasms
Legumain is an independent predictor for invasive recurrence in breast ductal carcinoma in situ.
Neoplasms
Legumain protease-activated TAT-liposome cargo for targeting tumours and their microenvironment.
Neoplasms
Legumain protease-activated tuftsin-functionalized nanoparticles for dual-targeting TAMs and cancer chemotherapy.
Neoplasms
Legumain-cleavable 4-arm poly(ethylene glycol)-doxorubicin conjugate for tumor specific delivery and release.
Neoplasms
Legumain-deficient macrophages promote senescence of tumor cells by sustaining JAK1/STAT1 activation.
Neoplasms
Legumain-Specific Near-Infrared Fluorescence "Turn On" for Tumor-Targeted Imaging.
Neoplasms
Legumain/asparaginyl endopeptidase controls extracellular matrix remodeling through the degradation of fibronectin in mouse renal proximal tubular cells.
Neoplasms
M2 tumour-associated macrophages contribute to tumour progression via legumain remodelling the extracellular matrix in diffuse large B cell lymphoma.
Neoplasms
Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation.
Neoplasms
MiRNA-Embedded ShRNAs for Radiation-Inducible LGMN Knockdown and the Antitumor Effects on Breast Cancer.
Neoplasms
Modulation of invasive properties of murine squamous carcinoma cells by heterologous expression of cathepsin B and cystatin C.
Neoplasms
Molecular-dynamics-simulation-driven design of a protease-responsive probe for in-vivo tumor imaging.
Neoplasms
N-Terminomics/TAILS Profiling of Macrophages after Chemical Inhibition of Legumain.
Neoplasms
Noncovalent complexes between the lysosomal proteinase cathepsin B and its propeptide account for stable, extracellular, high molecular mass forms of the enzyme.
Neoplasms
Oral DNA vaccines target the tumor vasculature and microenvironment and suppress tumor growth and metastasis.
Neoplasms
Overexpression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy.
Neoplasms
Peptide-based MRI contrast agent and near-infrared fluorescent probe for intratumoral legumain detection.
Neoplasms
Peptidomic analysis of breast cancer reveals a putative surrogate marker for estrogen receptor-negative carcinomas.
Neoplasms
Phaseolin Attenuates Lipopolysaccharide-Induced Inflammation in RAW 264.7 Cells and Zebrafish.
Neoplasms
Phaseolin Gene from Bean Is Expressed After Transfer to Sunflower Via Tumor-Inducing Plasmid Vectors.
Neoplasms
Protease activity of legumain is inhibited by an increase of cystatin E/M in the DJ-1-knockout mouse spleen, cerebrum and heart.
Neoplasms
Pseudogene legumain promotes thyroid carcinoma progression via the microRNA-495/autophagy pathway.
Neoplasms
Radiofluorinated Smart Probes for Noninvasive PET Imaging of Legumain Activity in Living Subjects.
Neoplasms
Regulation of cathepsin B activity by modulators of arachidonic acid metabolism in human monocytes.
Neoplasms
Role of asparagine endopeptidase in mediating wild-type p53 inactivation of glioblastoma.
Neoplasms
Secretion of a latent, acid activatable cathepsin L precursor by human non-small cell lung cancer cell lines.
Neoplasms
Secretion of Legumain Increases in Conditioned Medium from DJ-1-Knockout Cells and in Serum from DJ-1-Knockout Mice.
Neoplasms
Selective ablation of tumor-associated macrophages suppresses metastasis and angiogenesis.
Neoplasms
Selective targeting of tumor and stromal cells by a nanocarrier system displaying lipidated cathepsin?b inhibitor.
Neoplasms
Single-dose in situ storage for intensifying anticancer efficacy via combinatorial strategy.
Neoplasms
Specific Inhibition of the VEGFR-3 Tyrosine Kinase by SAR131675 Reduces Peripheral and Tumor Associated Immunosuppressive Myeloid Cells.
Neoplasms
Structural and functional analysis of cystatin E reveals enzymologically relevant dimer and amyloid fibril states.
Neoplasms
Structure and mechanism of an aspartimide-dependent Peptide ligase in human legumain.
Neoplasms
Suppression of Asparaginyl Endopeptidase Inhibits Polyomavirus Middle T Antigen-Induced Tumor Formation and Metastasis.
Neoplasms
Synthesis and Evaluation of a CBZ-AAN-Dox Prodrug and its in vitro Effects on SiHa Cervical Cancer Cells Under Hypoxic Conditions.
Neoplasms
Synthesis and evaluation of aza-peptidyl inhibitors of the lysosomal asparaginyl endopeptidase, legumain.
Neoplasms
Synthesis and evaluation of radioactive/fluorescent peptide probes for imaging of legumain activity.
Neoplasms
Synthesis of a novel legumain-cleavable colchicine prodrug with cell-specific toxicity.
Neoplasms
Tailor-made legumain/pH dual-responsive doxorubicin prodrug-embedded nanoparticles for efficient anticancer drug delivery and in situ monitoring of drug release.
Neoplasms
Targeted delivery of doxorubicin to tumour tissues by a novel legumain sensitive polygonal nanogel.
Neoplasms
Targeting cell surface alpha(v)beta(3) integrin increases therapeutic efficacies of a legumain protease-activated auristatin prodrug.
Neoplasms
Targeting cell-impermeable prodrug activation to tumor microenvironment eradicates multiple drug-resistant neoplasms.
Neoplasms
TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities.
Neoplasms
The expression of asparaginyl endopeptidase promotes growth potential in epithelial ovarian cancer.
Neoplasms
The legumain protease-activated auristatin prodrugs suppress tumor growth and metastasis without toxicity.
Neoplasms
The LGMN pseudogene promotes tumor progression by acting as a miR-495-3p sponge in glioblastoma.
Neoplasms
The Mechanism of Asparagine Endopeptidase in the Progression of Malignant Tumors: A Review.
Neuroblastoma
Legumain correlates with neuroblastoma differentiation and can be used in prodrug design.
Neurodegenerative Diseases
Asparagine endopeptidase is an innovative therapeutic target for neurodegenerative diseases.
Neurodegenerative Diseases
BDNF inhibits neurodegenerative disease-associated asparaginyl endopeptidase activity via phosphorylation by AKT.
Neurodegenerative Diseases
Legumain acts on neuroinflammatory to affect CUS-induced cognitive impairment.
Neurodegenerative Diseases
Mammalian legumain - A lysosomal cysteine protease with extracellular functions?
Neurodegenerative Diseases
N-Terminomics/TAILS Profiling of Macrophages after Chemical Inhibition of Legumain.
Neuroinflammatory Diseases
Asparagine endopeptidase inhibitor protects against fenpropathrin-induced neurodegeneration via suppressing ?-synuclein aggregation and neuroinflammation.
Neuroinflammatory Diseases
Legumain acts on neuroinflammatory to affect CUS-induced cognitive impairment.
Neuroinflammatory Diseases
Legumain knockout improved cognitive impairment via reducing neuroinflammation in right unilateral common carotid artery occlusion mice.
Neuroinflammatory Diseases
Legumain Knockout Protects Against A?1-42-Induced AD-like Cognitive Deficits and Synaptic Plasticity Dysfunction Via Inhibiting Neuroinflammation Without Cleaving APP.
Neurologic Manifestations
The asparaginyl endopeptidase legumain after experimental stroke.
Opisthorchiasis
Asparaginyl endopeptidase from the carcinogenic liver fluke, Opisthorchis viverrini, and its potential for serodiagnosis.
Osteoporosis
Mammalian legumain - A lysosomal cysteine protease with extracellular functions?
Osteoporosis, Postmenopausal
Legumain Regulates Differentiation Fate of Human Bone Marrow Stromal Cells and Is Altered in Postmenopausal Osteoporosis.
Ovarian Neoplasms
Determination of cathepsin B expression may offer additional prognostic information for ovarian cancer patients.
Ovarian Neoplasms
Legumain: a biomarker for diagnosis and prognosis of human ovarian cancer.
Pancreatitis, Chronic
Legumain promotes fibrogenesis in chronic pancreatitis via activation of transforming growth factor ?1.
Parkinson Disease
?-Synuclein stimulation of monoamine oxidase-B and legumain protease mediates the pathology of Parkinson's disease.
Parkinson Disease
Asparagine endopeptidase cleaves ?-synuclein and mediates pathologic activities in Parkinson's disease.
Parkinson Disease
Asparagine endopeptidase cleaves synaptojanin 1 and triggers synaptic dysfunction in Parkinson's disease.
Periapical Periodontitis
iTRAQ-based quantitative analysis of alveolar bone resorption in rats with experimental periodontitis.
Prostatic Neoplasms
Asparaginyl endopeptidase promotes proliferation and invasiveness of prostate cancer cells via PI3K/AKT signaling pathway.
Prostatic Neoplasms
Association of legumain expression pattern with prostate cancer invasiveness and aggressiveness.
Prostatic Neoplasms
SUMO-Specific Cysteine Protease 1 Promotes Epithelial Mesenchymal Transition of Prostate Cancer Cells via Regulating SMAD4 deSUMOylation.
Rectal Neoplasms
Clinicopathologic significance of legumain overexpression in cancer: a systematic review and meta-analysis.
Reperfusion Injury
Lysophosphatidic acid induces neuronal cell death via activation of asparagine endopeptidase in cerebral ischemia-reperfusion injury.
Root Resorption
Immunolocalization of vacuolar-type H+-ATPase, cathepsin K, matrix metalloproteinase-9, and receptor activator of NFkappaB ligand in odontoclasts during physiological root resorption of human deciduous teeth.
Schistosomiasis
Immunogenicity of polymerizable synthetic peptides derived from a vaccine candidate against schistosomiasis: the asparaginyl endopeptidase (Sm32).
Schistosomiasis
Lipid core peptide targeting the cathepsin D hemoglobinase of Schistosoma mansoni as a component of a schistosomiasis vaccine.
Schistosomiasis
Neutralizing antibodies to the hookworm hemoglobinase Na-APR-1: implications for a multivalent vaccine against hookworm infection and schistosomiasis.
Spinal Cord Injuries
The asparaginyl endopeptidase legumain is essential for functional recovery after spinal cord injury in adult zebrafish.
ST Elevation Myocardial Infarction
Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages.
Starvation
A Novel Antitumor Prodrug Platform Designed to Be Cleaved by the Endoprotease Legumain.
Stomach Neoplasms
Asparaginyl endopeptidase improves the resistance of microtubule-targeting drugs in gastric cancer through IQGAP1 modulating the EGFR/JNK/ERK signaling pathway.
Stomach Neoplasms
Asparaginyl endopeptidase promotes the invasion and metastasis of gastric cancer through modulating epithelial-to-mesenchymal transition and analysis of their phosphorylation signaling pathways.
Stomach Neoplasms
Expression of both poly r(C) binding protein 1 (PCBP1) and miRNA-3978 is suppressed in peritoneal gastric cancer metastasis.
Stomach Neoplasms
High Level of Legumain Was Correlated With Worse Prognosis and Peritoneal Metastasis in Gastric Cancer Patients.
Stomach Neoplasms
Legumain is a predictive effector of peritoneal metastasis for diffuse gastric cancer patients.
Stomach Neoplasms
Legumain Promotes Gastric Cancer Progression Through Tumor-associated Macrophages In vitro and In vivo.
Stomach Neoplasms
MiRNA-3978 regulates peritoneal gastric cancer metastasis by targeting legumain.
Stroke
Legumain in Acute Coronary Syndromes: A Substudy of the PLATO (Platelet Inhibition and Patient Outcomes) Trial.
Stroke
Lysophosphatidic acid induces neuronal cell death via activation of asparagine endopeptidase in cerebral ischemia-reperfusion injury.
Tetanus
Asparagine deamidation perturbs antigen presentation on class II major histocompatibility complex molecules.
Thyroid Neoplasms
Influence of proliferation, differentiation and dedifferentiation factors on the expression of the lysosomal cysteine proteinase cathepsin L (CL) in thyroid cancer cell lines.
Thyroid Neoplasms
Pseudogene legumain promotes thyroid carcinoma progression via the microRNA-495/autophagy pathway.
Ureteral Obstruction
Legumain, an asparaginyl endopeptidase, mediates the effect of M2 macrophages on attenuating renal interstitial fibrosis in obstructive nephropathy.
Uterine Cervical Neoplasms
Knockdown of Legumain Suppresses Cervical Cancer Cell Migration and Invasion.
Virus Diseases
Kaposi's sarcoma-associated herpesvirus infection promotes differentiation and polarization of monocytes into tumor-associated macrophages.
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