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Disease on EC 3.4.22.34 - Legumain

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DISEASE
TITLE OF PUBLICATION
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Acidosis
Activation of asparaginyl endopeptidase leads to Tau hyperphosphorylation in Alzheimer disease.
Animal models of the sporadic form of Alzheimer's disease: focus on the disease and not just the lesions.
Mechanism of Tau Hyperphosphorylation Involving Lysosomal Enzyme Asparagine Endopeptidase in a Mouse Model of Brain Ischemia.
Acute Coronary Syndrome
Legumain in Acute Coronary Syndromes: A Substudy of the PLATO (Platelet Inhibition and Patient Outcomes) Trial.
Adenocarcinoma
Asparaginyl endopeptidase enhances pancreatic ductal adenocarcinoma cell invasion in an exosome-dependent manner and correlates with poor prognosis.
Effects of legumain as a potential prognostic factor on gastric cancers.
Legumain: a biomarker for diagnosis and prognosis of human ovarian cancer.
Adenocarcinoma of Lung
Immunohistochemical distributions of cathepsin B and basement membrane antigens in human lung adenocarcinoma: association with invasion and metastasis.
Alzheimer Disease
Activation of asparaginyl endopeptidase leads to Tau hyperphosphorylation in Alzheimer disease.
Animal models of the sporadic form of Alzheimer's disease: focus on the disease and not just the lesions.
Asparagine Endopeptidase (? Secretase), an Enzyme Implicated in Alzheimer's Disease Pathology, Is an Inhibitor of Axon Regeneration in Peripheral Nerves.
Cerebrospinal fluid tau fragment correlates with tau PET: a candidate biomarker for tangle pathology.
Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.
Cuprizone and EAE mouse frontal cortex proteomics revealed proteins altered in multiple sclerosis.
Delta- and beta- secretases crosstalk amplifies the amyloidogenic pathway in Alzheimer's disease.
Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease.
Imaging asparaginyl endopeptidase (AEP) in the live brain as a biomarker for Alzheimer's disease.
Increased cross-linking micelle retention in the brain of Alzheimer's disease mice by elevated asparagine endopeptidase protease responsive aggregation.
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Involvement of Activation of Asparaginyl Endopeptidase in Tau Hyperphosphorylation in Repetitive Mild Traumatic Brain Injury.
Lack of association between LGMN and Alzheimer's disease in the Southern Han Chinese population.
Structural and functional analysis of cystatin E reveals enzymologically relevant dimer and amyloid fibril states.
Structure and function of legumain in health and disease.
Anaphylaxis
A case of severe anaphylaxis to kidney bean: phaseolin (vicilin) and PHA (lectin) identified as putative allergens.
Atherosclerosis
Expression of the cysteine protease legumain in vascular lesions and functional implications in atherogenesis.
Increased Legumain/Smad3 expression in atherosclerotic plaque of rat thoracic aorta.
Increased levels of legumain in plasma and plaques from patients with carotid atherosclerosis.
Legumain acts on neuroinflammatory to affect CUS-induced cognitive impairment.
Legumain in Acute Coronary Syndromes: A Substudy of the PLATO (Platelet Inhibition and Patient Outcomes) Trial.
Legumain is activated in macrophages during pancreatitis.
Legumain Promotes Atherosclerotic Vascular Remodeling.
Legumain suppresses OxLDL-induced macrophage apoptosis through enhancement of the autophagy pathway.
Legumain/asparaginyl endopeptidase controls extracellular matrix remodeling through the degradation of fibronectin in mouse renal proximal tubular cells.
Mammalian legumain - A lysosomal cysteine protease with extracellular functions?
Synthesis and evaluation of aza-peptidyl inhibitors of the lysosomal asparaginyl endopeptidase, legumain.
Autoimmune Diseases
Autophagic activity measured in whole rat hepatocytes as the accumulation of a novel BHMT fragment (p10), generated in amphisomes by the asparaginyl proteinase, legumain.
Bone Resorption
Identification of human asparaginyl endopeptidase (legumain) as an inhibitor of osteoclast formation and bone resorption.
In vivo and in vitro evidence for the involvement of cysteine proteinases in bone resorption.
Osteoclast inhibitory peptide 2 inhibits osteoclast formation via its C-terminal fragment.
Proteome analysis of secreted proteins during osteoclast differentiation using two different methods: two-dimensional electrophoresis and isotope-coded affinity tags analysis with two-dimensional chromatography.
Structure and chromosomal assignment of the human cathepsin K gene.
Brain Concussion
Involvement of Activation of Asparaginyl Endopeptidase in Tau Hyperphosphorylation in Repetitive Mild Traumatic Brain Injury.
Brain Ischemia
Activation of asparaginyl endopeptidase leads to Tau hyperphosphorylation in Alzheimer disease.
Legumain knockout improved cognitive impairment via reducing neuroinflammation in right unilateral common carotid artery occlusion mice.
Mechanism of Tau Hyperphosphorylation Involving Lysosomal Enzyme Asparagine Endopeptidase in a Mouse Model of Brain Ischemia.
Brain Neoplasms
Increased Gold Nanoparticle Retention in Brain Tumors by in Situ Enzyme-Induced Aggregation.
Breast Neoplasms
A Legumain-based minigene vaccine targets the tumor stroma and suppresses breast cancer growth and angiogenesis.
Accumulation of Memory Precursor CD8 T Cells in Regressing Tumors Following Combination Therapy with Vaccine and Anti-PD-1 Antibody.
Alginic acid-coated chitosan nanoparticles loaded with legumain DNA vaccine: effect against breast cancer in mice.
C/EBP?/AEP Signaling Regulates the Oxidative Stress in Malignant Cancers, Stimulating the Metastasis.
Development of a selected reaction monitoring mass spectrometry-based assay to detect asparaginyl endopeptidase activity in biological fluids.
Effects of legumain as a potential prognostic factor on gastric cancers.
Legumain expression as a prognostic factor in breast cancer patients.
Legumain is an independent predictor for invasive recurrence in breast ductal carcinoma in situ.
Legumain protein as a potential predictive biomarker for asian patients with breast carcinoma.
MiRNA-Embedded ShRNAs for Radiation-Inducible LGMN Knockdown and the Antitumor Effects on Breast Cancer.
Suppression of asparaginyl endopeptidase attenuates breast cancer-induced bone pain through inhibition of neurotrophin receptors.
Suppression of Asparaginyl Endopeptidase Inhibits Polyomavirus Middle T Antigen-Induced Tumor Formation and Metastasis.
TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities.
Bronchiectasis
Noncovalent complexes between the lysosomal proteinase cathepsin B and its propeptide account for stable, extracellular, high molecular mass forms of the enzyme.
Carcinogenesis
Asparaginyl endopeptidase improves the resistance of microtubule-targeting drugs in gastric cancer through IQGAP1 modulating the EGFR/JNK/ERK signaling pathway.
Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain.
Effects of legumain as a potential prognostic factor on gastric cancers.
Expression of legumain correlates with prognosis and metastasis in gastric carcinoma.
Functional imaging of legumain in cancer using a new quenched activity-based probe.
Molecular-dynamics-simulation-driven design of a protease-responsive probe for in-vivo tumor imaging.
Peptide-based MRI contrast agent and near-infrared fluorescent probe for intratumoral legumain detection.
Carcinoma
A Novel Antitumor Prodrug Platform Designed to Be Cleaved by the Endoprotease Legumain.
Asparaginyl endopeptidase enhances pancreatic ductal adenocarcinoma cell invasion in an exosome-dependent manner and correlates with poor prognosis.
Expression of legumain correlates with prognosis and metastasis in gastric carcinoma.
Latency of cathepsin B secreted by human colon carcinoma cells is not linked to secretion of cystatin C and is relieved by neutrophil elastase.
Legumain expression in relation to clinicopathologic and biological variables in colorectal cancer.
MiRNA-3978 regulates peritoneal gastric cancer metastasis by targeting legumain.
Modulation of invasive properties of murine squamous carcinoma cells by heterologous expression of cathepsin B and cystatin C.
Overexpression of asparaginyl endopeptidase is significant for esophageal carcinoma metastasis and predicts poor patient prognosis.
Carcinoma, Ductal
Legumain is an independent predictor for invasive recurrence in breast ductal carcinoma in situ.
Carcinoma, Hepatocellular
Proteolytic processing and glycosylation of cathepsin B. The role of the primary structure of the latent precursor and of the carbohydrate moiety for cell-type-specific molecular forms of the enzyme.
Carcinoma, Intraductal, Noninfiltrating
Legumain is an independent predictor for invasive recurrence in breast ductal carcinoma in situ.
Carcinoma, Ovarian Epithelial
The expression of asparaginyl endopeptidase promotes growth potential in epithelial ovarian cancer.
Carcinoma, Squamous Cell
Invasive properties of murine squamous carcinoma cells: secretion of matrix-degrading cathepsins is attributable to a deficiency in the mannose 6-phosphate/insulin-like growth factor II receptor.
Cardiovascular Diseases
Associations of Interleukin 10, Matrix Metallopeptidase 9, and Legumain with Blood Pressure Variability and Neurologic Outcomes in Patients with Ischemic Stroke.
Legumain in Acute Coronary Syndromes: A Substudy of the PLATO (Platelet Inhibition and Patient Outcomes) Trial.
Legumain in cardiovascular disease: Culprit or ally?
Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages.
Carotid Artery Diseases
Increased levels of legumain in plasma and plaques from patients with carotid atherosclerosis.
Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages.
Legumain Promotes Atherosclerotic Vascular Remodeling.
Carotid Stenosis
Increased levels of legumain in plasma and plaques from patients with carotid atherosclerosis.
Chronic Periodontitis
Cathepsin B in gingival crevicular fluid of adult periodontitis patients: identification by immunological and enzymological methods.
Clonorchiasis
Identification of a serodiagnostic antigen, legumain, by immunoproteomic analysis of excretory-secretory products of Clonorchis sinensis adult worms.
Colorectal Neoplasms
Correction: Nuclear Legumain Activity in Colorectal Cancer.
Effects of legumain as a potential prognostic factor on gastric cancers.
High expression of the cysteine proteinase legumain in colorectal cancer - implications for therapeutic targeting.
Legumain expression in relation to clinicopathologic and biological variables in colorectal cancer.
Legumain: a biomarker for diagnosis and prognosis of human ovarian cancer.
Nuclear legumain activity in colorectal cancer.
Synthesis of a novel legumain-cleavable colchicine prodrug with cell-specific toxicity.
Coronary Artery Disease
High Plasma Levels of Legumain in Patients with Complex Coronary Lesions.
Cystic Fibrosis
Activity of the lysosomal cysteine proteinases (cathepsin B,H,L) and a metalloproteinase (MMP-7-ase) in the serum of cystic fibrosis homozygous children.
Dementia
Development of a selected reaction monitoring mass spectrometry-based assay to detect asparaginyl endopeptidase activity in biological fluids.
Demyelinating Diseases
Exploring the factors underlying remyelination arrest by studying the post-transcriptional regulatory mechanisms of cystatin F gene.
Microglial cystatin F expression is a sensitive indicator for ongoing demyelination with concurrent remyelination.
Diabetes Mellitus, Type 2
Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages.
Esophageal Neoplasms
Overexpression of asparaginyl endopeptidase is significant for esophageal carcinoma metastasis and predicts poor patient prognosis.
Food Hypersensitivity
Occupational food allergy due to parvalbumin and phaseolin induced by epicutaneous sensitization.
Ganglioneuroblastoma
Legumain correlates with neuroblastoma differentiation and can be used in prodrug design.
Glioblastoma
Inactivation of Wild-Type p53 by Asparagine Endopeptidase in Glioblastoma: An Opportunity to Target the "Undruggable".
Role of asparagine endopeptidase in mediating wild-type p53 inactivation of glioblastoma.
Upregulation of LGMNP1 confers radiotherapy resistance in glioblastoma.
Glioma
Aggregable Nanoparticles-Enabled Chemotherapy and Autophagy Inhibition Combined with Anti-PD-L1 Antibody for Improved Glioma Treatment.
Inhibition of cathepsin L sensitizes human glioma cells to ionizing radiation in vitro through NF-?B signaling pathway.
Heart Rupture
Legumain is a predictor of all-cause mortality and potential therapeutic target in acute myocardial infarction.
Hookworm Infections
An enzymatically inactivated hemoglobinase from Necator americanus induces neutralizing antibodies against multiple hookworm species and protects dogs against heterologous hookworm infection.
Neutralizing antibodies to the hookworm hemoglobinase Na-APR-1: implications for a multivalent vaccine against hookworm infection and schistosomiasis.
Vaccination with recombinant aspartic hemoglobinase reduces parasite load and blood loss after hookworm infection in dogs.
Hypercalcemia
Identification of human asparaginyl endopeptidase (legumain) as an inhibitor of osteoclast formation and bone resorption.
Hyperglycemia
Activation of asparaginyl endopeptidase leads to Tau hyperphosphorylation in Alzheimer disease.
Hypersensitivity
Phaseolin: a 47.5kDa protein of red kidney bean (Phaseolus vulgaris L.) plays a pivotal role in hypersensitivity induction.
Hypertension
Legumain in Pulmonary Arterial Hypertension.
Hypertension, Pulmonary
Macrophage-Derived Legumain Promotes Pulmonary Hypertension by Activating the MMP (Matrix Metalloproteinase)-2/TGF (Transforming Growth Factor)-?1 Signaling.
Infections
Asparagine Endopeptidase Controls Anti-Influenza Virus Immune Responses through TLR7 Activation.
Asparaginyl endopeptidase from the carcinogenic liver fluke, Opisthorchis viverrini, and its potential for serodiagnosis.
Cathepsin B-Deficient Mice Resolve Leishmania major Inflammation Faster in a T Cell-Dependent Manner.
The C-terminal extension of Leishmania pifanoi amastigote-specific cysteine proteinase Lpcys2: A putative function in macrophage infection.
Ischemic Stroke
Associations of Interleukin 10, Matrix Metallopeptidase 9, and Legumain with Blood Pressure Variability and Neurologic Outcomes in Patients with Ischemic Stroke.
Legumain Knockout Protects Against A?1-42-Induced AD-like Cognitive Deficits and Synaptic Plasticity Dysfunction Via Inhibiting Neuroinflammation Without Cleaving APP.
legumain deficiency
Genomic Analysis of Storage Protein Deficiency in Genetically Related Lines of Common Bean (Phaseolus vulgaris).
Legumain promotes fibrogenesis in chronic pancreatitis via activation of transforming growth factor ?1.
Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI.
Legumain suppresses OxLDL-induced macrophage apoptosis through enhancement of the autophagy pathway.
The asparaginyl endopeptidase legumain after experimental stroke.
Leukemia
RAC2, AEP, and ICAM1 expression are associated with CNS disease in a mouse model of pre-B childhood acute lymphoblastic leukemia.
Liver Cirrhosis
Asparaginyl endopeptidase may promote liver sinusoidal endothelial cell angiogenesis via PI3K/Akt pathway.
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
Lyme Disease
Multiple legumain isoenzymes in ticks.
Lymphatic Metastasis
Legumain expression in relation to clinicopathologic and biological variables in colorectal cancer.
Lymphohistiocytosis, Hemophagocytic
Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome.
Lymphoma
M2 tumour-associated macrophages contribute to tumour progression via legumain remodelling the extracellular matrix in diffuse large B cell lymphoma.
Lymphoma, B-Cell
M2 tumour-associated macrophages contribute to tumour progression via legumain remodelling the extracellular matrix in diffuse large B cell lymphoma.
Lymphoma, Large B-Cell, Diffuse
M2 tumour-associated macrophages contribute to tumour progression via legumain remodelling the extracellular matrix in diffuse large B cell lymphoma.
Malaria
Cloning and characterization of Plasmodium falciparum cysteine protease, falcipain-2B.
Design, synthesis and biological evaluation of functionalized phthalimides: A new class of antimalarials and inhibitors of falcipain-2, a major hemoglobinase of malaria parasite.
Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum: a catabolic pathway initiated by a specific aspartic protease.
High-level expression of Falcipain-2 in Escherichia coli by codon optimization and auto-induction.
Oxidation and Tyrosine Nitration Induce Structural Changes and Inhibits Plasmodium falciparum Falcipain-2 Activity In Vitro.
Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease.
Structural features of falcipain-3 inhibitors: an in silico study.
Synthesis and molecular modeling studies of derivatives of a highly potent peptidomimetic vinyl ester as falcipain-2 inhibitors.
Measles
Immunological reactions after measles vaccination.
Melanoma
Contact of high-invasive, but not low-invasive, melanoma cells to native collagen I induces the release of mature cathepsin B.
Cystatin E/M suppresses legumain activity and invasion of human melanoma.
Fabrication of chitosan based nanocomposite with legumain sensitive properties using charge driven self-assembly strategy.
Low-level internalization of cystatin E/M affects legumain activity and migration of melanoma cells.
Prognostic value of legumain in uveal melanoma.
Mouth Neoplasms
Legumain Induces Oral Cancer Pain by Biased Agonism of Protease-Activated Receptor-2.
Silencing of cystatin M in metastatic oral cancer cell line MDA-686Ln by siRNA increases cysteine proteinases and legumain activities, cell proliferation and in vitro invasion.
Multiple Sclerosis
Cuprizone and EAE mouse frontal cortex proteomics revealed proteins altered in multiple sclerosis.
Myocardial Infarction
Legumain in Acute Coronary Syndromes: A Substudy of the PLATO (Platelet Inhibition and Patient Outcomes) Trial.
Legumain is a predictor of all-cause mortality and potential therapeutic target in acute myocardial infarction.
Myotoxicity
Simvastatin inhibits glucose metabolism and legumain activity in human myotubes.
Neoplasm Metastasis
A Novel Antitumor Prodrug Platform Designed to Be Cleaved by the Endoprotease Legumain.
Asparaginyl endopeptidase induces endothelial permeability and tumor metastasis via downregulating zonula occludens protein ZO-1.
Asparaginyl endopeptidase promotes the invasion and metastasis of gastric cancer through modulating epithelial-to-mesenchymal transition and analysis of their phosphorylation signaling pathways.
Autoactivation of prolegumain is accelerated by glycosaminoglycans.
Autophagic activity measured in whole rat hepatocytes as the accumulation of a novel BHMT fragment (p10), generated in amphisomes by the asparaginyl proteinase, legumain.
Blockade of Asparagine Endopeptidase Inhibits Cancer Metastasis.
C/EBP?/AEP Signaling Regulates the Oxidative Stress in Malignant Cancers, Stimulating the Metastasis.
Cystatin C properties crucial for uptake and inhibition of intracellular target enzymes.
Effect of protein kinase modulators on the regulation of cathepsin B activity in THP-1 human monocytic leukemia cells.
Effects of legumain as a potential prognostic factor on gastric cancers.
Esomeprazole inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis.
Evaluation of the anti-cervical cancer effect of a prodrug ?CBZ-AAN-DOX with hypoxic cell culture and tumor-bearing zebrafish models.
Expression of both poly r(C) binding protein 1 (PCBP1) and miRNA-3978 is suppressed in peritoneal gastric cancer metastasis.
Expression of legumain correlates with prognosis and metastasis in gastric carcinoma.
Functional Role of Asparaginyl Endopeptidase Ubiquitination by TRAF6 in Tumor Invasion and Metastasis.
High Level of Legumain Was Correlated With Worse Prognosis and Peritoneal Metastasis in Gastric Cancer Patients.
Legumain expression in relation to clinicopathologic and biological variables in colorectal cancer.
Legumain is a predictive effector of peritoneal metastasis for diffuse gastric cancer patients.
MiRNA-3978 regulates peritoneal gastric cancer metastasis by targeting legumain.
Modulation of invasive properties of murine squamous carcinoma cells by heterologous expression of cathepsin B and cystatin C.
Overexpression of asparaginyl endopeptidase is significant for esophageal carcinoma metastasis and predicts poor patient prognosis.
Overexpression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy.
Radiofluorinated Smart Probes for Noninvasive PET Imaging of Legumain Activity in Living Subjects.
Regulation of cathepsin B activity by modulators of arachidonic acid metabolism in human monocytes.
Suppression of asparaginyl endopeptidase attenuates breast cancer-induced bone pain through inhibition of neurotrophin receptors.
Suppression of Asparaginyl Endopeptidase Inhibits Polyomavirus Middle T Antigen-Induced Tumor Formation and Metastasis.
Synthesis and evaluation of radioactive/fluorescent peptide probes for imaging of legumain activity.
The legumain protease-activated auristatin prodrugs suppress tumor growth and metastasis without toxicity.
Neoplasms
A Legumain-based minigene vaccine targets the tumor stroma and suppresses breast cancer growth and angiogenesis.
A new tandem peptide modified liposomal doxorubicin for tumor "ecological therapy".
A Novel Antitumor Prodrug Platform Designed to Be Cleaved by the Endoprotease Legumain.
A novel legumain protease-activated micelle cargo enhances anticancer activity and cellular internalization of doxorubicin.
A possible mechanism for the long-lasting antitumor effect of the macromolecular conjugate DE-310: mediation by cellular uptake and drug release of its active camptothecin analog DX-8951.
A protease-responsive fluorescent probe for sensitive imaging of legumain activity in living tumor cells.
A synthetic enzyme inhibitor is a novel targeting ligand for nanotherapeutic drug delivery inhibiting primary tumor growth without systemic toxicity.
Activation of legumain involves proteolytic and conformational events, resulting in a context- and substrate-dependent activity profile.
An intracellular form of cathepsin B contributes to invasiveness in cancer.
An Overview on Targeting Legumain for Inhibiting Cancers.
Antibody-Prodrug Conjugates with KSP Inhibitors and Legumain-Mediated Metabolite Formation.
Asparaginyl endopeptidase enhances pancreatic ductal adenocarcinoma cell invasion in an exosome-dependent manner and correlates with poor prognosis.
Asparaginyl endopeptidase induces endothelial permeability and tumor metastasis via downregulating zonula occludens protein ZO-1.
Asparaginyl endopeptidase may promote liver sinusoidal endothelial cell angiogenesis via PI3K/Akt pathway.
Asparaginyl endopeptidase promotes proliferation and invasiveness of prostate cancer cells via PI3K/AKT signaling pathway.
Association of legumain expression pattern with prostate cancer invasiveness and aggressiveness.
Autoactivation of prolegumain is accelerated by glycosaminoglycans.
Autophagic activity measured in whole rat hepatocytes as the accumulation of a novel BHMT fragment (p10), generated in amphisomes by the asparaginyl proteinase, legumain.
Bioengineered Macrophages Can Responsively Transform into Nanovesicles To Target Lung Metastasis.
Biological characterization of laryngeal squamous-cell carcinoma.
Blockade of Asparagine Endopeptidase Inhibits Cancer Metastasis.
C/EBP?/AEP Signaling Regulates the Oxidative Stress in Malignant Cancers, Stimulating the Metastasis.
Cathepsin B expression in colorectal carcinomas correlates with tumor progression and shortened patient survival.
Cathepsin L is highly expressed in gastrointestinal stromal tumors.
Characterization of a cysteine proteinase secreted by mouse mammary gland.
Clinicopathologic significance of legumain overexpression in cancer: a systematic review and meta-analysis.
Comparative localization of cathepsin B protein and activity in colorectal cancer.
Cooperatively Responsive Peptide Nanotherapeutic that Regulates Angiopoietin Receptor Tie2 Activity in Tumor Microenvironment To Prevent Breast Tumor Relapse after Chemotherapy.
Cystatin C properties crucial for uptake and inhibition of intracellular target enzymes.
Cystatin E/M suppresses legumain activity and invasion of human melanoma.
Determination of cathepsin B expression may offer additional prognostic information for ovarian cancer patients.
Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain.
Effect of protein kinase modulators on the regulation of cathepsin B activity in THP-1 human monocytic leukemia cells.
Effects of legumain as a potential prognostic factor on gastric cancers.
Enhancement of DNA vaccine potency against legumain.
Enzyme-Agnostic Lysosomal Screen Identifies New Legumain-Cleavable ADC Linkers.
Esomeprazole inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis.
Evaluation of the anti-cervical cancer effect of a prodrug ?CBZ-AAN-DOX with hypoxic cell culture and tumor-bearing zebrafish models.
Expression and protease activity of mouse legumain are regulated by the oncogene/transcription co-activator, DJ-1 through p53 and cleavage of annexin A2 is increased in DJ-1-knockout cells.
Expression of legumain correlates with prognosis and metastasis in gastric carcinoma.
Fabrication of chitosan based nanocomposite with legumain sensitive properties using charge driven self-assembly strategy.
Functional imaging of legumain in cancer using a new quenched activity-based probe.
Functional recombinant human Legumain protein expression in Pichia pastoris to enable screening for Legumain small molecule inhibitors.
Functional Role of Asparaginyl Endopeptidase Ubiquitination by TRAF6 in Tumor Invasion and Metastasis.
Genetically-engineered protein prodrug-like nanoconjugates for tumor-targeting biomimetic delivery via a SHEATH strategy.
Glatiramer acetate blocks the activation of THP-1 cells by interferon-gamma.
High expression of the cysteine proteinase legumain in colorectal cancer - implications for therapeutic targeting.
High Level of Legumain Was Correlated With Worse Prognosis and Peritoneal Metastasis in Gastric Cancer Patients.
IMD-0354 Targets Breast Cancer Stem Cells: A Novel Approach for an Adjuvant to Chemotherapy to Prevent Multidrug Resistance in a Murine Model.
Inhibition of cathepsin L sensitizes human glioma cells to ionizing radiation in vitro through NF-?B signaling pathway.
Intra- and extracellular regulation of activity and processing of legumain by cystatin E/M.
Intracellular and extracellular cathepsin B facilitate invasion of MCF-10A neoT cells through reconstituted extracellular matrix in vitro.
iRGD-Mediated and Enzyme-Induced Precise Targeting and Retention of Gold Nanoparticles for the Enhanced Imaging and Treatment of Breast Cancer.
Knockdown of legumain inhibits cleavage of annexin A2 in the mouse kidney.
Knockdown of Legumain Suppresses Cervical Cancer Cell Migration and Invasion.
Legumain acts on neuroinflammatory to affect CUS-induced cognitive impairment.
Legumain correlates with neuroblastoma differentiation and can be used in prodrug design.
Legumain expression as a prognostic factor in breast cancer patients.
Legumain expression in relation to clinicopathologic and biological variables in colorectal cancer.
Legumain is activated in macrophages during pancreatitis.
Legumain is an independent predictor for invasive recurrence in breast ductal carcinoma in situ.
Legumain protease-activated TAT-liposome cargo for targeting tumours and their microenvironment.
Legumain protease-activated tuftsin-functionalized nanoparticles for dual-targeting TAMs and cancer chemotherapy.
Legumain-cleavable 4-arm poly(ethylene glycol)-doxorubicin conjugate for tumor specific delivery and release.
Legumain-deficient macrophages promote senescence of tumor cells by sustaining JAK1/STAT1 activation.
Legumain-Specific Near-Infrared Fluorescence "Turn On" for Tumor-Targeted Imaging.
Legumain/asparaginyl endopeptidase controls extracellular matrix remodeling through the degradation of fibronectin in mouse renal proximal tubular cells.
Legumain: a biomarker for diagnosis and prognosis of human ovarian cancer.
M2 tumour-associated macrophages contribute to tumour progression via legumain remodelling the extracellular matrix in diffuse large B cell lymphoma.
Mammalian legumain - A lysosomal cysteine protease with extracellular functions?
Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation.
MiRNA-Embedded ShRNAs for Radiation-Inducible LGMN Knockdown and the Antitumor Effects on Breast Cancer.
Modelling family 2 cystatins and their interaction with papain.
Modulation of invasive properties of murine squamous carcinoma cells by heterologous expression of cathepsin B and cystatin C.
Molecular-dynamics-simulation-driven design of a protease-responsive probe for in-vivo tumor imaging.
N-Terminomics/TAILS Profiling of Macrophages after Chemical Inhibition of Legumain.
Noncovalent complexes between the lysosomal proteinase cathepsin B and its propeptide account for stable, extracellular, high molecular mass forms of the enzyme.
Nuclear legumain activity in colorectal cancer.
Oral DNA vaccines target the tumor vasculature and microenvironment and suppress tumor growth and metastasis.
Overexpression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy.
Peptide-based MRI contrast agent and near-infrared fluorescent probe for intratumoral legumain detection.
Peptidomic analysis of breast cancer reveals a putative surrogate marker for estrogen receptor-negative carcinomas.
Phaseolin Attenuates Lipopolysaccharide-Induced Inflammation in RAW 264.7 Cells and Zebrafish.
Phaseolin Gene from Bean Is Expressed After Transfer to Sunflower Via Tumor-Inducing Plasmid Vectors.
Phorbol ester stimulated cathepsin L expression in U937 cells.
Protease activity of legumain is inhibited by an increase of cystatin E/M in the DJ-1-knockout mouse spleen, cerebrum and heart.
Pseudogene legumain promotes thyroid carcinoma progression via the microRNA-495/autophagy pathway.
Radiofluorinated Smart Probes for Noninvasive PET Imaging of Legumain Activity in Living Subjects.
Regulation of cathepsin B activity by modulators of arachidonic acid metabolism in human monocytes.
Role of asparagine endopeptidase in mediating wild-type p53 inactivation of glioblastoma.
Secretion of a latent, acid activatable cathepsin L precursor by human non-small cell lung cancer cell lines.
Secretion of Legumain Increases in Conditioned Medium from DJ-1-Knockout Cells and in Serum from DJ-1-Knockout Mice.
Selective ablation of tumor-associated macrophages suppresses metastasis and angiogenesis.
Selective targeting of tumor and stromal cells by a nanocarrier system displaying lipidated cathepsin?b inhibitor.
Single-dose in situ storage for intensifying anticancer efficacy via combinatorial strategy.
Specific Inhibition of the VEGFR-3 Tyrosine Kinase by SAR131675 Reduces Peripheral and Tumor Associated Immunosuppressive Myeloid Cells.
Structural and functional analysis of cystatin E reveals enzymologically relevant dimer and amyloid fibril states.
Structure and function of legumain in health and disease.
Structure and mechanism of an aspartimide-dependent Peptide ligase in human legumain.
Suppression of Asparaginyl Endopeptidase Inhibits Polyomavirus Middle T Antigen-Induced Tumor Formation and Metastasis.
Synthesis and Evaluation of a CBZ-AAN-Dox Prodrug and its in vitro Effects on SiHa Cervical Cancer Cells Under Hypoxic Conditions.
Synthesis and evaluation of aza-peptidyl inhibitors of the lysosomal asparaginyl endopeptidase, legumain.
Synthesis and evaluation of radioactive/fluorescent peptide probes for imaging of legumain activity.
Synthesis of a novel legumain-cleavable colchicine prodrug with cell-specific toxicity.
Tailor-made legumain/pH dual-responsive doxorubicin prodrug-embedded nanoparticles for efficient anticancer drug delivery and in situ monitoring of drug release.
Targeted delivery of doxorubicin to tumour tissues by a novel legumain sensitive polygonal nanogel.
Targeting cell surface alpha(v)beta(3) integrin increases therapeutic efficacies of a legumain protease-activated auristatin prodrug.
Targeting cell-impermeable prodrug activation to tumor microenvironment eradicates multiple drug-resistant neoplasms.
Targeting legumain as a novel therapeutic strategy in cancers.
TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities.
The expression of asparaginyl endopeptidase promotes growth potential in epithelial ovarian cancer.
The legumain protease-activated auristatin prodrugs suppress tumor growth and metastasis without toxicity.
The LGMN pseudogene promotes tumor progression by acting as a miR-495-3p sponge in glioblastoma.
The Mechanism of Asparagine Endopeptidase in the Progression of Malignant Tumors: A Review.
Transcriptional regulation of the legumain gene by p53 in HCT116 cells.
Neuroblastoma
Legumain correlates with neuroblastoma differentiation and can be used in prodrug design.
Neurodegenerative Diseases
Asparagine endopeptidase is an innovative therapeutic target for neurodegenerative diseases.
BDNF inhibits neurodegenerative disease-associated asparaginyl endopeptidase activity via phosphorylation by AKT.
Legumain acts on neuroinflammatory to affect CUS-induced cognitive impairment.
Mammalian legumain - A lysosomal cysteine protease with extracellular functions?
N-Terminomics/TAILS Profiling of Macrophages after Chemical Inhibition of Legumain.
Neuroinflammatory Diseases
Asparagine endopeptidase inhibitor protects against fenpropathrin-induced neurodegeneration via suppressing ?-synuclein aggregation and neuroinflammation.
Legumain acts on neuroinflammatory to affect CUS-induced cognitive impairment.
Legumain knockout improved cognitive impairment via reducing neuroinflammation in right unilateral common carotid artery occlusion mice.
Legumain Knockout Protects Against A?1-42-Induced AD-like Cognitive Deficits and Synaptic Plasticity Dysfunction Via Inhibiting Neuroinflammation Without Cleaving APP.
Neurologic Manifestations
The asparaginyl endopeptidase legumain after experimental stroke.
Opisthorchiasis
Asparaginyl endopeptidase from the carcinogenic liver fluke, Opisthorchis viverrini, and its potential for serodiagnosis.
Osteoporosis
Mammalian legumain - A lysosomal cysteine protease with extracellular functions?
Osteoporosis, Postmenopausal
Legumain Regulates Differentiation Fate of Human Bone Marrow Stromal Cells and Is Altered in Postmenopausal Osteoporosis.
Ovarian Neoplasms
Determination of cathepsin B expression may offer additional prognostic information for ovarian cancer patients.
Legumain: a biomarker for diagnosis and prognosis of human ovarian cancer.
Pancreatitis
Legumain is activated in macrophages during pancreatitis.
Pancreatitis, Chronic
Legumain is activated in macrophages during pancreatitis.
Legumain promotes fibrogenesis in chronic pancreatitis via activation of transforming growth factor ?1.
Parkinson Disease
?-Synuclein stimulation of monoamine oxidase-B and legumain protease mediates the pathology of Parkinson's disease.
Asparagine endopeptidase cleaves ?-synuclein and mediates pathologic activities in Parkinson's disease.
Asparagine endopeptidase cleaves synaptojanin 1 and triggers synaptic dysfunction in Parkinson's disease.
Periapical Periodontitis
iTRAQ-based quantitative analysis of alveolar bone resorption in rats with experimental periodontitis.
Prostatic Neoplasms
Asparaginyl endopeptidase promotes proliferation and invasiveness of prostate cancer cells via PI3K/AKT signaling pathway.
Association of legumain expression pattern with prostate cancer invasiveness and aggressiveness.
SUMO-Specific Cysteine Protease 1 Promotes Epithelial Mesenchymal Transition of Prostate Cancer Cells via Regulating SMAD4 deSUMOylation.
Pulmonary Arterial Hypertension
Legumain in Pulmonary Arterial Hypertension.
Rectal Neoplasms
Clinicopathologic significance of legumain overexpression in cancer: a systematic review and meta-analysis.
Reperfusion Injury
Lysophosphatidic acid induces neuronal cell death via activation of asparagine endopeptidase in cerebral ischemia-reperfusion injury.
Root Resorption
Immunolocalization of vacuolar-type H+-ATPase, cathepsin K, matrix metalloproteinase-9, and receptor activator of NFkappaB ligand in odontoclasts during physiological root resorption of human deciduous teeth.
Schistosomiasis
Immunogenicity of polymerizable synthetic peptides derived from a vaccine candidate against schistosomiasis: the asparaginyl endopeptidase (Sm32).
Lipid core peptide targeting the cathepsin D hemoglobinase of Schistosoma mansoni as a component of a schistosomiasis vaccine.
Neutralizing antibodies to the hookworm hemoglobinase Na-APR-1: implications for a multivalent vaccine against hookworm infection and schistosomiasis.
Spinal Cord Injuries
The asparaginyl endopeptidase legumain is essential for functional recovery after spinal cord injury in adult zebrafish.
ST Elevation Myocardial Infarction
Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages.
Starvation
A Novel Antitumor Prodrug Platform Designed to Be Cleaved by the Endoprotease Legumain.
Stomach Neoplasms
Asparaginyl endopeptidase improves the resistance of microtubule-targeting drugs in gastric cancer through IQGAP1 modulating the EGFR/JNK/ERK signaling pathway.
Asparaginyl endopeptidase promotes the invasion and metastasis of gastric cancer through modulating epithelial-to-mesenchymal transition and analysis of their phosphorylation signaling pathways.
Effects of legumain as a potential prognostic factor on gastric cancers.
Expression of both poly r(C) binding protein 1 (PCBP1) and miRNA-3978 is suppressed in peritoneal gastric cancer metastasis.
High Level of Legumain Was Correlated With Worse Prognosis and Peritoneal Metastasis in Gastric Cancer Patients.
Legumain is a predictive effector of peritoneal metastasis for diffuse gastric cancer patients.
Legumain Promotes Gastric Cancer Progression Through Tumor-associated Macrophages In vitro and In vivo.
MiRNA-3978 regulates peritoneal gastric cancer metastasis by targeting legumain.
Stroke
Legumain in Acute Coronary Syndromes: A Substudy of the PLATO (Platelet Inhibition and Patient Outcomes) Trial.
Legumain is activated in macrophages during pancreatitis.
Lysophosphatidic acid induces neuronal cell death via activation of asparagine endopeptidase in cerebral ischemia-reperfusion injury.
The asparaginyl endopeptidase legumain after experimental stroke.
Tetanus
Asparagine deamidation perturbs antigen presentation on class II major histocompatibility complex molecules.
Control of antigen presentation by a single protease cleavage site.
Enhancement of DNA vaccine potency against legumain.
Legumain forms from plants and animals differ in their specificity.
Thyroid Neoplasms
Influence of proliferation, differentiation and dedifferentiation factors on the expression of the lysosomal cysteine proteinase cathepsin L (CL) in thyroid cancer cell lines.
Pseudogene legumain promotes thyroid carcinoma progression via the microRNA-495/autophagy pathway.
Ureteral Obstruction
Legumain, an asparaginyl endopeptidase, mediates the effect of M2 macrophages on attenuating renal interstitial fibrosis in obstructive nephropathy.
Uterine Cervical Neoplasms
Knockdown of Legumain Suppresses Cervical Cancer Cell Migration and Invasion.
Virus Diseases
Kaposi's sarcoma-associated herpesvirus infection promotes differentiation and polarization of monocytes into tumor-associated macrophages.
Two vacuole-mediated defense strategies in plants.