3.4.22.34: Legumain

This is an abbreviated version!
For detailed information about Legumain, go to the full flat file.

Word Map on EC 3.4.22.34

3.4.22.34

cathepsins

phaseolus

vulgaris

vacuole

cystatins

proteinases

metastasis

papain

cotyledon

plasmodium

globulin

falciparum

vicilins

schistosoma

papain-like

tau

legume

endopeptidases

seed-specific

mesoamerican

phytohemagglutinin

falcipain-2

clan

mansoni

andean

leguminous

procathepsins

lunatus

cyclotides

jack

caspase-1-like

drug development

biotechnology

medicine

diagnostics

Reaction

hydrolysis of proteins and small molecule substrates at -Asn-/-Xaa- bonds =

Synonyms

AEP, Antigen Sj32, Antigen SM32, As-specific vacuolar cysteine proteinase, Asn-specific vacuolar cysteine proteinase, asparagine endopeptidase, asparaginly endopeptidase, asparaginyl endopepidase, Asparaginyl endopeptidase, asparaginyl endopeptidase legumain, asparaginyl endopeptidase,, asparaginyl proteinase, asparaginyl-specific cysteine endopeptidase, asparagyl-endopeptidase, aspartate-specific endopeptidase, AtLEGgamma, Bean endopeptidase, C197 legumain, c197 Sm32, cysteine protease 1, hemoglobinase, HlLgm, HlLgm2, IrAE, IrAE protein, isae1, isae2, LeG, LEG-1, Leg-2, Leg-4, Leg1, Leg2, Leg3, Leg4, Leg5, legumain, legumain-1, LGMN, lysosomal asparaginycysteine endopeptidase, lysosomal asparaginyl endopeptidase, lysosomal cysteine proteinase, More, N197 legumain, osteoclast inhibitory peptide 2, Ov-aep-1, Phaseolin, Proteinase B, PrVPE1, schistosome legumain, Sj32, Sm32, SmAE, SmAE protein, SPAE, TcLEG3, TcLEG6, TcLEG9, TvAE1, vacuolar processing enzyme, vacuolar processing enzyme 1a, vacuolar processing enzyme 1b, vacuolar processing enzyme 2, vacuolar processing enzyme 3, Vicilin peptidohydrolase, VPE, VPE1a, VPE1b, VPE2, VPE3

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.22 Cysteine endopeptidases

3.4.22.34 Legumain

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Results	in table
22	Activating Compound
1004	AA Sequence
6	Application
1	CAS Registry Number
49	Cloned(Commentary)
3	Crystallization (Commentary)
1114	Disease/ Diagnostics
17	Expression
14	General Information
10	General Stability
266	IC50 Value
466	Inhibitors
47	Ki Value [mM]
15	KM Value [mM]
70	Localization
1	Metals/Ions
58	Molecular Weight [Da]
77	Natural Substrates/ Products (Substrates)
124	Organism
61	PDB ID
53	pH Optimum
13	pH Range
7	pH Stability
2	pI Value
48	Posttranslational Modification
16	Protein Variants
39	Purification (Commentary)
7	Reaction
34	Reaction Type
123	Reference
1	Renatured (Commentary)
167	Source Tissue
49	Specific Activity [micromol/min/mg]
3	Storage Stability
324	Substrates and Products (Substrate)
30	Subunits
197	Synonyms
28	Temperature Optimum [°C]
2	Temperature Range [°C]
5	Temperature Stability [°C]
5	Turnover Number [1/s]

pH Stability

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pH Stability on EC 3.4.22.34 - Legumain

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3 - 6

Sus scrofa

stable, irreversible denaturation at higher pH

668775

3 - 7

Vigna aconitifolia

26.5°C, very stable

30313

4 - 5.5

Homo sapiens

Q99538

the thermal stability of active legumain is highest in the pH interval 4.0-5.5, with a melting temperature Tm of 60°C. At pH values higher than 6.0 the melting temperature Tm decreased to below 30°C

717046

Homo sapiens

Q99538

the isolated enzyme becomes irreversibly denatured at pH values above 6.0

731134

Homo sapiens

no enzymatic activity at pH 7.0, legumain undergoes denaturation at these basic conditions

696499

7.5

Canavalia ensiformis

even with additives the enzyme is labile above

30311

additional information

2 entries