3.4.22.16: cathepsin H
This is an abbreviated version!
For detailed information about cathepsin H, go to the full flat file.
Word Map on EC 3.4.22.16
Reaction
Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg-/- bonds) as well as an endopeptidase =
Synonyms
aleurain, aleuron thiol protease, alpha-N-benzoyl-arginine 2-naphthylamide hydrolase, alpha-N-benzoylarginine-beta-naphthylamide hydrolase, Cat H, CatB3, CatH, cathepsin B3, cathepsin Ba, cathepsin H, cathepsin H-like cysteine proteinase, CTSH, procathepsin H
ECTree
3.4.22.16 cathepsin HAdvanced search results
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Engineering on EC 3.4.22.16 - cathepsin H
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
C26S
site-directed mutagenesis, catalytically inactive active site mutant
C80S
site-directed mutagenesis, the mutation removes the disulfide between the mini-chain and the mature domain and completely abolishes the protease activity
H166A
site-directed mutagenesis, catalytically inactive active site mutant
N186A
site-directed mutagenesis, catalytically inactive active site mutant
T83A
site-directed mutagenesis, mutation of the Thr83 of the mini-chain has only mild effects on the enzyme activity
additional information
additional information
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mutant lacking the mini chain, loss of aminopeptidase activity, increase in endopeptidase activity
additional information
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mutant lacking the mini-chain, T11_E18del-cathepsin H, minimal aminopeptidase activity against good wild type substrates, endopeptidase activity against Z-L-Phe-L-Arg-NH-4-methylcoumaryl-7-amide, which is not cleaved by wild type
additional information
generation of short hairpin RNA Ctsh knockout and heterozygote mice into C57BL/6J background
additional information
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generation of short hairpin RNA Ctsh knockout and heterozygote mice into C57BL/6J background
additional information
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generation of short hairpin RNA Ctsh knockout and heterozygote mice into C57BL/6J background
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additional information
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mutant lacking the mini chain, loss of aminopeptidase activity, increase in endopeptidase activity
