3.4.22.16: cathepsin H
This is an abbreviated version!
For detailed information about cathepsin H, go to the full flat file.
Word Map on EC 3.4.22.16
Reaction
Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg-/- bonds) as well as an endopeptidase =
Synonyms
aleurain, aleuron thiol protease, alpha-N-benzoyl-arginine 2-naphthylamide hydrolase, alpha-N-benzoylarginine-beta-naphthylamide hydrolase, Cat H, CatB3, CatH, cathepsin B3, cathepsin Ba, cathepsin H, cathepsin H-like cysteine proteinase, CTSH, procathepsin H
ECTree
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Reference on EC 3.4.22.16 - cathepsin H
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lenney, J.F.; Liao, J.R.; Sugg, S.L.; Gopalakrishnan, V.; Wong, H.C.H.; Ouye, K.H.; Chan, P.W.H.
Low molecular weight inhibitors of cathepsins B, H and T in human serum, synovial fluid and CSF
Biochem. Biophys. Res. Commun.
108
1581-1587
1982
Homo sapiens
Barrett, A.J.; Kirschke, H.
Cathepsin B, Cathepsin H, and cathepsin L
Methods Enzymol.
80
535-561
1981
Homo sapiens, Rattus norvegicus
Lenney, J.F.; Tolan, J.R.; Sugai, W.J.; Lee, A.G.
Thermostable endogenous inhibitors of cathepsins B and H
Eur. J. Biochem.
101
153-161
1979
Homo sapiens, Paramecium caudatum, Rattus norvegicus, Sus scrofa, Tetrahymena pyriformis
Taniguchi, T.; Mizuochi, T.; Towatari, T.; Katunuma, N.; Kobata, A.
Structural studies on the carbohydrate moieties of rat liver cathepsins B and H
J. Biochem.
97
973-976
1985
Rattus norvegicus
Fuchs, R.; Machleidt, W.; Gassen, H.G.
Molecular cloning and sequencing of a cDNA coding for mature human kidney cathepsin H
Biol. Chem. Hoppe-Seyler
369
469-475
1988
Homo sapiens
Popovic, T.; Brzin, J.; Kos, J.; Lenarcic, B.; Machleidt, W.; Ritonja, A.; Hanada, K.; Turk, V.
A new purification procedure of human kidney cathepsin H, its properties ans kinetic data
Biol. Chem. Hoppe-Seyler
369
175-183
1988
Homo sapiens
-
Hara, K.; Kominami, E.; Katunuma, N.
Effect of proteinase inhibitors on intracellular processing of cathepsin B, H and L in rat macrophages
FEBS Lett.
231
229-231
1988
Rattus norvegicus
Ritonja, A.; Popovic, T.; Kotnik, M.; Machleidt, W.; Turk, V.
Amino acid sequences of the human kidney cathepsins H and L
FEBS Lett.
228
341-345
1988
Homo sapiens
Nishimura, Y.; Amano, J.; Sato, H.; Tsuji, H.; Kato, K.
Biosynthesis of lysosomal cathepsins B and H in cultures rat hepatocytes
Arch. Biochem. Biophys.
262
159-170
1988
Rattus norvegicus
Ishidoh, K.; Imajoh, S.; Emori, Y.; Ohno, S.; Kawasaki, H.; Minami, Y.; Kominami, E.; Katunuma, N.; Suzuki, K.
Molecular cloning and sequencing of cDNA for rat cathepsin H
FEBS Lett.
226
33-37
1987
Rattus norvegicus
Brümme, D.; Bescherer, K.; Kirschke, H.; Fittkau, S.
Enzyme-substrate interactions in the hydrolysis of peptides by cathepsins B and H from rat liver
Biochem. J.
245
381-385
1987
Rattus norvegicus
Rogers, J.C.; Dean, D.; Heck, G.R.
Aleurain: a barley thiol protease closely related to mammalian cathepsin H
Proc. Natl. Acad. Sci. USA
82
6512-6516
1985
Hordeum vulgare
Kominami, E.; Tsukahara, T.; Bando, Y.; Katunuma, N.
Distribution of cathepsins B and H in rat tissues and peripheral blood cells
J. Biochem.
98
87-93
1985
Rattus norvegicus
Willenbrock, F.; Brocklehurst, K.
Preparation of cathepsins B and H by covalent chromatography and characterization of their catalytic sites by reaction with a thiol-specific two-protonic-state reactivity probe
Biochem. J.
85
511-519
1985
Bos taurus
-
Takahashi, T.; Dehdarani, A.H.; Schmidt, P.G.; Tang, J.
Cathepsins B and H from porcine spleen
J. Biol. Chem.
259
9874-9882
1984
Sus scrofa
Takio, K.; Towatari, T.; Katunuma, N.; Teller, D.C.; Titani, K.
Homology of amino acid sequences of rat liver cathepsins B and H with that of papain
Proc. Natl. Acad. Sci. USA
80
3666-3670
1983
Rattus norvegicus
Bergmeyer, H.U.ed
Cathepsin B, cathepsin H, and cathepsin L
Methods Enzym. Anal. (3rd. ed. )
5
195-210
1984
Homo sapiens, Rattus norvegicus
-
Schwartz, W.N.; Barrett, A.J.
Human cathepsin H
Biochem. J.
191
487-497
1980
Homo sapiens, Rattus norvegicus
Singh, H.; Kalnitsky, G.
Separation of a new alpha-N-benzoylarginine-beta-naphthylamide hydrolase from cathepsin B1
J. Biol. Chem.
253
4319-4326
1978
Oryctolagus cuniculus
Sivaparvathi, M.; Sawaya, R.; Gokaslan, Z.L.; Chintala, K.S.; Rao, J.S.
Expression and the role of cathepsin H in human glioma progression and invasion
Cancer Lett.
104
121-126
1996
Homo sapiens, Rattus norvegicus
Aranishi, F.; Hara, K.; Osatomi, K.; Ishihara, T.
Substrate specificity of carp Cyprinus carpio cathepsin H with methylcoumarylamide substrates
Comp. Biochem. Physiol. B
116B
203-208
1997
Cyprinus carpio
Guncar, G.; Podobnik, M.; Pungercar, J.; Strukelj, B.; Turk, V.; Turk, D.
Crystal structure of porcine cathepsin H determined at 2.1 A resolution: location of the mini-chain C-terminal carboxyl group defines cathepsin H aminopeptidase function
Structure
6
51-61
1998
Homo sapiens, Sus scrofa
Rothe, M.; Doth, J.
Studies on the aminopeptidase activity of rat cathepsin H
Eur. J. Biochem.
210
759-764
1992
Rattus norvegicus
Raghav, N.; Kamboj, R.C.; Parnami, S.; Singh, H.
Physico-chemical properties of brain cathepsin H
Indian J. Biochem. Biophys.
32
279-285
1995
Bos taurus
Aranishi, F.; Hara, K.; Ishinara, T.
Purification and characterization of cathepsin H from hepatopancreas of carp Cyprinus carpio
Comp. Biochem. Physiol. B
102B
499-505
1992
Cyprinus carpio
Yamamoto, K.; Kamata, O.; Kato, Y.
Separation and properties of three forms of cathepsin H-like cysteine proteinase from rat spleen
J. Biochem.
95
477-484
1984
Rattus norvegicus
Kominami, E.; Katunuma, N.
Immunological studies on cathepsins B and H from rat liver
J. Biochem.
91
67-71
1982
Rattus norvegicus
Kamphuis, I.G.; Drenth, J.; Baker, E.N.
Thiol proteases: comparative studies on the high-resolution structures of papain and actinidin, and on amino acid sequence information for cathepsins B and H, and stem bromelain
J. Mol. Biol.
182
317-329
1985
Homo sapiens
Vasiljeva, O.; Dolinar, M.; Turk, V.; Turk, B.
Recombinant human cathepsin H lacking the mini chain is an endopeptidase
Biochemistry
42
13522-13528
2003
Homo sapiens, Sus scrofa
Dodt, J.; Reichwein, J.
Human cathepsin H: deletion of the mini-chain switches substrate specificity from aminopeptidase to endopeptidase
Biol. Chem.
384
1327-1332
2003
Homo sapiens
Matsuishi, M.; Saito, G.; Okitani, A.; Kato, H.
Purification and some properties of cathepsin H from rabbit skeletal muscle
Int. J. Biochem. Cell Biol.
35
474-485
2003
Oryctolagus cuniculus
Jenko, S.; Dolenc, I.; Guncar, G.; Dobersek, A.; Podobnik, M.; Turk, D.
Crystal structure of stefin A in complex with cathepsin H: N-terminal residues of inhibitors can adapt to the active sites of endo- and exopeptidases
J. Mol. Biol.
326
875-885
2003
Sus scrofa
Brguljan, P.M.; Turk, V.; Nina, C.; Brzin, J.; Krizaj, I.; Popovic, T.
Human brain cathepsin H as a neuropeptide and bradykinin metabolizing enzyme
Peptides
24
1977-1984
2003
Homo sapiens
Froehlich, E.; Moehrle, M.; Klessen, C.
Cathepsins in basal cell carcinomas: activity, immunoreactivity and mRNA staining of cathepsins B, D, H and L. [Erratum to document cited in CA141:021292]
Arch. Dermatol. Res.
296
94
2004
Homo sapiens
-
Bratkovic, T.; Lunder, M.; Popovic, T.; Kreft, S.; Turk, B.; Strukelj, B.; Urleb, U.
Affinity selection to papain yields potent peptide inhibitors of cathepsins L, B, H, and K
Biochem. Biophys. Res. Commun.
332
897-903
2005
Homo sapiens
Horn, M.; Doleckova-Maresova, L.; Rulisek, L.; Masa, M.; Vasiljeva, O.; Turk, B.; Gan-Erdene, T.; Baudys, M.; Mares, M.
Activation processing of cathepsin H impairs recognition by its propeptide
Biol. Chem.
386
941-947
2005
Homo sapiens (P09668)
Chornaya, V.; Lyannaya, O.
Some physicochemical properties of cathepsin H from human meningioma
Exp. Oncol.
26
278-281
2004
Homo sapiens
Ueno, T.; Linder, S.; Na, C.L.; Rice, W.R.; Johansson, J.; Weaver, T.E.
Processing of pulmonary surfactant protein B by napsin and cathepsin H
J. Biol. Chem.
279
16178-16184
2004
Homo sapiens
Serveau-Avesque, C.; Ferrer-Di Martino, M.; Herve-Grepinet, V.; Hazouard, E.; Gauthier, F.; Diot, E.; Lalmanach, G.
Active cathepsins B, H, K, L and S in human inflammatory bronchoalveolar lavage fluids
Biol. Cell.
98
15-22
2006
Homo sapiens
Torikai, H.; Akatsuka, Y.; Miyazaki, M.; Tsujimura, A.; Yatabe, Y.; Kawase, T.; Nakao, Y.; Tsujimura, K.; Motoyoshi, K.; Morishima, Y.; Kodera, Y.; Kuzushima, K.; Takahashi, T.
The human cathepsin H gene encodes two novel minor histocompatibility antigen epitopes restricted by HLA-A*3101 and -A*3303
Br. J. Haematol.
134
406-416
2006
Homo sapiens (P09668), Homo sapiens
Woischnik, M.; Bauer, A.; Aboutaam, R.; Pamir, A.; Stanzel, F.; de Blic, J.; Griese, M.
Cathepsin H and napsin A are active in the alveoli and increased in alveolar proteinosis
Eur. Respir. J.
31
1197-1204
2008
Homo sapiens (P09668), Homo sapiens
Lue, J.; Qian, J.; Keppler, D.; Cardoso, W.V.
Cathepsin H is an Fgf10 target involved in Bmp4 degradation during lung branching morphogenesis
J. Biol. Chem.
282
22176-22184
2007
Mus musculus
Nagaraj, N.S.; Santhanam, K.
Effect of frozen temperature and storage time on calpains, cathepsins (B, B + L, H and D) and their endogenous inhibitors in goat muscles
J. Food Biochem.
30
155-173
2006
Capra aegagrus
Yeh, H.Y.; Klesius, P.H.
Channel catfish, Ictalurus punctatus, cysteine proteinases: cloning, characterisation and expression of cathepsin H and L
Fish Shellfish Immunol.
26
332-338
2009
Ictalurus punctatus (B5LVX3), Ictalurus punctatus
Sethadavit, M.; Meemon, K.; Jardim, A.; Spithill, T.W.; Sobhon, P.
Identification, expression and immunolocalization of cathepsin B3, a stage-specific antigen expressed by juvenile Fasciola gigantica
Acta Trop.
112
164-173
2009
Fasciola gigantica (Q86MW6), Fasciola gigantica
Li, J.; Petrassi, H.; Tumanut, C.; Masick, B.; Trussell, C.; Harris, J.
Substrate optimization for monitoring cathepsin C activity in live cells
Bioorg. Med. Chem.
17
1064-1070
2009
Homo sapiens
D'Angelo, M.E.; Bird, P.I.; Peters, C.; Reinheckel, T.; Trapani, J.A.; Sutton, V.R.
Cathepsin H is an additional convertase of pro-granzyme B
J. Biol. Chem.
285
20514-20519
2010
Mus musculus
Buehling, F.; Kouadio, M.; Chwieralski, C.E.; Kern, U.; Hohlfeld, J.M.; Klemm, N.; Friedrichs, N.; Roth, W.; Deussing, J.M.; Peters, C.; Reinheckel, T.
Gene targeting of the cysteine peptidase cathepsin H impairs lung surfactant in mice
PLoS ONE
6
e26247
2011
Mus musculus
Raghav, N.; Garg, S.
N-formylpyrazolines and N-benzoylpyrazolines as novel inhibitors of mammalian cathepsin B and cathepsin H
Bioorg. Chem.
57
43-50
2014
Capra hircus
Singh, M.; Raghav, N.
2,3-Dihydroquinazolin-4(1H)-one derivatives as potential non-peptidyl inhibitors of cathepsins B and H
Bioorg. Chem.
59
12-22
2015
Capra hircus
Raghav, N.; Singh, M.
Acyl hydrazides and triazoles as novel inhibitors of mammalian cathepsin B and cathepsin H
Eur. J. Med. Chem.
77
231-242
2014
Capra hircus
Jevnikar, Z.; Rojnik, M.; Jamnik, P.; Doljak, B.; Fonovic, U.P.; Kos, J.
Cathepsin H mediates the processing of talin and regulates migration of prostate cancer cells
J. Biol. Chem.
288
2201-2209
2013
Homo sapiens
Lu, W.D.; Funkelstein, L.; Toneff, T.; Reinheckel, T.; Peters, C.; Hook, V.
Cathepsin H functions as an aminopeptidase in secretory vesicles for production of enkephalin and galanin peptide neurotransmitters
J. Neurochem.
122
512-522
2012
Bos taurus, Mus musculus
Raghav, N.; Singh, M.
SAR studies of differently functionalized chalcones based hydrazones and their cyclized derivatives as inhibitors of mammalian cathepsin B and cathepsin H
Bioorg. Med. Chem.
22
4233-4245
2014
Capra hircus
Garg, S.; Raghav, N.
2,5-Diaryloxadiazoles and their precursors as novel inhibitors of cathepsins B, H and L
Bioorg. Chem.
67
64-74
2016
Capra hircus (A0A060INS8)
Raghav, N.; Kaur, R.
Chalcones, semicarbazones and pyrazolines as inhibitors of cathepsins B, H and L
Int. J. Biol. Macromol.
80
710-724
2015
Capra hircus (A0A060INS8)
Naeem, A.S.; Tommasi, C.; Cole, C.; Brown, S.J.; Zhu, Y.; Way, B.; Willis Owen, S.A.; Moffatt, M.; Cookson, W.O.; Harper, J.I.; Di, W.L.; Brown, S.J.; Reinheckel, T.; O'Shaughnessy, R.F.
A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis
J. Allergy Clin. Immunol.
139
1228-1241
2017
Rattus norvegicus (P00786), Homo sapiens (P09668), Homo sapiens, Mus musculus (P49935), Mus musculus, Mus musculus C57BL/6J (P49935)
Raghav, N.; Kaur, R.
A comparative account of sar studies of semicarbazones and thiosemicarbazones on cathepsins H and L
Med. Chem. Res.
26
1723-1734
2017
Capra hircus (A0A060INS8)
-
Hao, Y.; Purtha, W.; Cortesio, C.; Rui, H.; Gu, Y.; Chen, H.; Sickmier, E.A.; Manzanillo, P.; Huang, X.
Crystal structures of human procathepsin H
PLoS ONE
13
e0200374
2018
Homo sapiens (P09668), Homo sapiens
Garg, S.; Raghav, N.
Inhibitory potential of some chalcones on cathepsins B, H and L
RSC Adv.
5
72937-72949
2015
Capra hircus (A0A060INS8)
-
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