3.4.22.16: cathepsin H

This is an abbreviated version!
For detailed information about cathepsin H, go to the full flat file.

Reaction

Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg-/- bonds) as well as an endopeptidase =

Synonyms

aleurain, aleuron thiol protease, alpha-N-benzoyl-arginine 2-naphthylamide hydrolase, alpha-N-benzoylarginine-beta-naphthylamide hydrolase, Cat H, CatB3, CatH, cathepsin B3, cathepsin Ba, cathepsin H, cathepsin H-like cysteine proteinase, CTSH, procathepsin H

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.16 cathepsin H

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Results	in table
27	Activating Compound
73	AA Sequence
3	Application
1	CAS Registry Number
9	Cloned(Commentary)
5	Crystallization (Commentary)
324	Disease/ Diagnostics
24	General Information
2	General Stability
310	Inhibitors
216	Ki Value [mM]
41	KM Value [mM]
15	Localization
36	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
74	Organism
20	PDB ID
32	pH Optimum
1	pH Range
9	pH Stability
1	pI Value
20	Posttranslational Modification
11	Protein Variants
20	Purification (Commentary)
6	Reaction
2	Reaction Type
74	Reference
93	Source Tissue
23	Specific Activity [micromol/min/mg]
7	Storage Stability
131	Substrates and Products (Substrate)
28	Subunits
30	Synonyms
20	Temperature Optimum [°C]
5	Temperature Stability [°C]
22	Turnover Number [1/s]

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TURNOVER NUMBER [1/s]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

1.87

Ala-4-methylcoumaryl-7-amide

Cyprinus carpio

-

-

638835

1.82 - 115

Arg-2-naphthylamide

2 entries

2.2 - 8.13

Arg-4-methylcoumaryl-7-amide

3 entries

1.82

benzoyl-Arg-2-naphthylamide

Homo sapiens

-

-

36634

0.63

benzoyl-Arg-4-methylcoumaryl-7-amide

Rattus norvegicus

-

at 30°C

638837

5.3

benzyloxycarbonyl-Pro-Ala-Ala-Ala-Pro

Rattus norvegicus

-

-

638821

7.7

benzyloxycarbonyl-Pro-Ala-Ala-Ala-Pro-NH2

Rattus norvegicus

-

-

638821

3.1

citrulline-4-methylcoumaryl-7-amide

Rattus norvegicus

-

at 30°C

638837

122

Leu-2-naphthylamide

Bos taurus

-

-

638838

1.1

Leu-4-methylcoumaryl-7-amide

Cyprinus carpio

-

-

638835

4.13

Lys-4-methylcoumaryl-7-amide

Cyprinus carpio

-

-

638835

219

Met-2-naphthylamide

Bos taurus

-

-

638838

0.07

succinyl-Ala-Ala-4-nitroanilide

Rattus norvegicus

-

-

638821

0.3

succinyl-Ala-Ala-Ala-4-nitroanilide

Rattus norvegicus

-

-

638821

0.9

succinyl-Ala-Ala-Ala-Ala-4-nitroanilide

Rattus norvegicus

-

-

638821

0.8

succinyl-Ala-Ala-Ala-Ala-Ala-4-nitroanilide

Rattus norvegicus

-

-

638821

0.004

succinyl-Ala-Ala-Pro-4-nitroanilide

Rattus norvegicus

-

-

638821

0.15

succinyl-Pro-Ala-Ala-4-nitroanilide

Rattus norvegicus

-

-

638821

additional information

additional information

Rattus norvegicus

-

pH and temperature dependence of kcat/Km

638837

-

1.82

Arg-2-naphthylamide

Homo sapiens

-

-

36634

115

Arg-2-naphthylamide

Bos taurus

-

-

638838

2.2

Arg-4-methylcoumaryl-7-amide

Cyprinus carpio

-

-

638835

2.53

Arg-4-methylcoumaryl-7-amide

Homo sapiens

-

-

36634

8.13

Arg-4-methylcoumaryl-7-amide

Rattus norvegicus

-

at 30°C

638837