3.4.22.16: cathepsin H
This is an abbreviated version!
For detailed information about cathepsin H, go to the full flat file.
Reaction
Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg-/- bonds) as well as an endopeptidase =
Synonyms
aleurain, aleuron thiol protease, alpha-N-benzoyl-arginine 2-naphthylamide hydrolase, alpha-N-benzoylarginine-beta-naphthylamide hydrolase, Cat H, CatB3, CatH, cathepsin B3, cathepsin Ba, cathepsin H, cathepsin H-like cysteine proteinase, CTSH, procathepsin H
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Application
Application on EC 3.4.22.16 - cathepsin H
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medicine
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tumor specific increase in cathepsin H antigen may be useful marker of tumor progression in central nervous system neoplasms
medicine
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enzyme activity, immunoreactivity, and mRNA in most basal cell carcinomas are higher than in normal skin. Reactive cells are located between and around tumor nodules, but not in tumor nests. Enzyme in peritumoral cells may either promote invasion of the tumor cells by degradation of the extracellular matrix or may reflect an elevated activity of the surrounding immunological cells
medicine
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enzyme from meningogioma shows a 3.5fold increased vmax-value compared to normal tissue, and a 1.3fold decrease in KM-value. Molecular weight of tumor enzyme is decreased