3.4.22.16: cathepsin H

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For detailed information about cathepsin H, go to the full flat file.

Reaction

Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg-/- bonds) as well as an endopeptidase =

Synonyms

aleurain, aleuron thiol protease, alpha-N-benzoyl-arginine 2-naphthylamide hydrolase, alpha-N-benzoylarginine-beta-naphthylamide hydrolase, Cat H, CatB3, CatH, cathepsin B3, cathepsin Ba, cathepsin H, cathepsin H-like cysteine proteinase, CTSH, procathepsin H

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.16 cathepsin H

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Results	in table
27	Activating Compound
73	AA Sequence
3	Application
1	CAS Registry Number
9	Cloned(Commentary)
5	Crystallization (Commentary)
324	Disease/ Diagnostics
24	General Information
2	General Stability
310	Inhibitors
216	Ki Value [mM]
41	KM Value [mM]
15	Localization
36	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
74	Organism
20	PDB ID
32	pH Optimum
1	pH Range
9	pH Stability
1	pI Value
20	Posttranslational Modification
11	Protein Variants
20	Purification (Commentary)
6	Reaction
2	Reaction Type
74	Reference
93	Source Tissue
23	Specific Activity [micromol/min/mg]
7	Storage Stability
131	Substrates and Products (Substrate)
28	Subunits
30	Synonyms
20	Temperature Optimum [°C]
5	Temperature Stability [°C]
22	Turnover Number [1/s]

pH Stability

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pH Stability on EC 3.4.22.16 - cathepsin H

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pH STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

4 - 7.5

Bos taurus

-

-

638838

5 - 9

Rattus norvegicus

-

-

638840

5.5 - 6

Cyprinus carpio

-

rapid inactivation above

638839

7

Homo sapiens

-

irreversible inactivation above

36634, 638831

8.2

Bos taurus

-

stable at 25°C, unstable at 37°C

638825

8.5

Oryctolagus cuniculus

-

83% activity

638833

additional information

2 entries

additional information

Homo sapiens

-

irreversibly inactivated at alkaline pH

638831

additional information

Oryctolagus cuniculus

-

little sensitivity to alkaline pH

638833