3.4.22.16: cathepsin H
This is an abbreviated version!
For detailed information about cathepsin H, go to the full flat file.
Reaction
Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg-/- bonds) as well as an endopeptidase =
Synonyms
aleurain, aleuron thiol protease, alpha-N-benzoyl-arginine 2-naphthylamide hydrolase, alpha-N-benzoylarginine-beta-naphthylamide hydrolase, Cat H, CatB3, CatH, cathepsin B3, cathepsin Ba, cathepsin H, cathepsin H-like cysteine proteinase, CTSH, procathepsin H
ECTree
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Subunits
Subunits on EC 3.4.22.16 - cathepsin H
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dimer
monomer
additional information
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two bands in SDS-PAGE of 23000 and 27000, respectively, interpreted as different stages of enzyme processing
additional information
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230 residues, 8 of which belong to SS-linked minichain, high sequnece homologies to cathepsin B and other cysteine proteinases of the papain superfamily
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protein predicted from cDNA contains 361 amino acids
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comparison of amino acid sequence to those of cathepsin B and papain reveals high degree of homology, equal contributions of monomeric and dimeric forms, model of tertiary structure, 2 free SH-groups postulated
additional information
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comparison to other proteinases of the papain superfamily: high sequence homologies