3.4.21.27: coagulation factor XIa
This is an abbreviated version!
For detailed information about coagulation factor XIa, go to the full flat file.
Word Map on EC 3.4.21.27
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3.4.21.27
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bleeding
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thrombin
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clot
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platelet
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thrombosis
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anticoagulant
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prothrombin
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kallikrein
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kininogen
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prekallikrein
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viii
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hemostasis
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venous
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fibrinogen
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antithrombin
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zymogen
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fibrinolysis
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procoagulant
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fibrin
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willebrand
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antithrombotic
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hemophilia
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thromboembolism
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plasmin
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ashkenazi
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fxiia
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hageman
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coagulopathy
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amidolytic
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diathesis
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haemostat
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thrombophilias
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leiden
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jewish
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antifibrinolytic
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kaolin
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proline-specific
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thrombin-activatable
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meningosepticum
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fletcher
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c1-inhibitor
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thromboelastometry
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drug development
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tenase
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medicine
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basque
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menorrhagia
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desmopressin
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tranexamic
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proline-containing
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tafi
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recalcified
- 3.4.21.27
- bleeding
- thrombin
- clot
- platelet
- thrombosis
-
anticoagulant
- prothrombin
- kallikrein
- kininogen
- prekallikrein
- viii
-
hemostasis
- venous
- fibrinogen
- antithrombin
- zymogen
-
fibrinolysis
-
procoagulant
- fibrin
- willebrand
-
antithrombotic
- hemophilia
- thromboembolism
- plasmin
-
ashkenazi
- fxiia
-
hageman
- coagulopathy
-
amidolytic
- diathesis
-
haemostat
- thrombophilias
- leiden
-
jewish
-
antifibrinolytic
- kaolin
-
proline-specific
-
thrombin-activatable
- meningosepticum
-
fletcher
- c1-inhibitor
-
thromboelastometry
- drug development
-
tenase
- medicine
-
basque
- menorrhagia
- desmopressin
-
tranexamic
-
proline-containing
- tafi
-
recalcified
Reaction
Selective cleavage of Arg-/-Ala and Arg-/-Val bonds in factor IX to form factor IXa =
Synonyms
activated blood-coagulation factor XI, activated coagulation factor XIa, activated factor XI, activated factor XIa, activated FXI, activated plasma thromboplastin antecedent, blood coagulation factor XIa, blood-coagulation factor XI, activated, blood-coagulation factor XIa, coagulation factor XI, coagulation factor XIa, factor XI, factor XIa, factor XIa catalytic domain, FXI, FXIa, fXIaCD, More, plasma thromboplastin antecedent, prolyl endopeptidase, protease factor XIa, PTA, recombinant human FXI370-607, rhFXI370-607
ECTree
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Crystallization
Crystallization on EC 3.4.21.27 - coagulation factor XIa
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full-length zymogen FXI, and the isolated active protease domain of activated factor IX in complex with natural and synthetic inhibitors. Intimate linkage of the apple domains into a disk-like platform around the base of the catalytic domain
hanging drop vapor diffusion
in complaex with inhibitors, hanging drop vapor diffusion method, using 0.2 M (NH4)2SO4, 25% (w/v) polyethylene glycol methyl ether 2000, and 100 mM NaOAc, pH 4.6
in complex with inhibitors, hanging drop vapor diffusion method, using 0.1 M citrate pH 4.7-5.2, 20-26% (w/v) PEG 4K
purified recombinant catalytic domain of mutant S434A/T475A/C482S/K437A complexed with benzylamidine, crystallization solution is 2.0 M ammonium sulfate, 0.1 M Tris-HCl, pH 8.5, overnight at 10 °C, cryoprotection by 20% v/v glycerol, X-ray diffraction structure determination and anaylsis at 2.25 A resolution