3.4.21.27: coagulation factor XIa
This is an abbreviated version!
For detailed information about coagulation factor XIa, go to the full flat file.
Word Map on EC 3.4.21.27
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3.4.21.27
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bleeding
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thrombin
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clot
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platelet
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thrombosis
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anticoagulant
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prothrombin
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kallikrein
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kininogen
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prekallikrein
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viii
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hemostasis
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venous
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fibrinogen
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antithrombin
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zymogen
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fibrinolysis
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procoagulant
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fibrin
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willebrand
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antithrombotic
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hemophilia
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thromboembolism
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plasmin
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ashkenazi
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fxiia
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hageman
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coagulopathy
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amidolytic
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diathesis
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haemostat
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thrombophilias
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leiden
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jewish
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antifibrinolytic
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kaolin
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proline-specific
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thrombin-activatable
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meningosepticum
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fletcher
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c1-inhibitor
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thromboelastometry
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drug development
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tenase
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medicine
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basque
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menorrhagia
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desmopressin
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tranexamic
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proline-containing
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tafi
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recalcified
- 3.4.21.27
- bleeding
- thrombin
- clot
- platelet
- thrombosis
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anticoagulant
- prothrombin
- kallikrein
- kininogen
- prekallikrein
- viii
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hemostasis
- venous
- fibrinogen
- antithrombin
- zymogen
-
fibrinolysis
-
procoagulant
- fibrin
- willebrand
-
antithrombotic
- hemophilia
- thromboembolism
- plasmin
-
ashkenazi
- fxiia
-
hageman
- coagulopathy
-
amidolytic
- diathesis
-
haemostat
- thrombophilias
- leiden
-
jewish
-
antifibrinolytic
- kaolin
-
proline-specific
-
thrombin-activatable
- meningosepticum
-
fletcher
- c1-inhibitor
-
thromboelastometry
- drug development
-
tenase
- medicine
-
basque
- menorrhagia
- desmopressin
-
tranexamic
-
proline-containing
- tafi
-
recalcified
Reaction
Selective cleavage of Arg-/-Ala and Arg-/-Val bonds in factor IX to form factor IXa =
Synonyms
activated blood-coagulation factor XI, activated coagulation factor XIa, activated factor XI, activated factor XIa, activated FXI, activated plasma thromboplastin antecedent, blood coagulation factor XIa, blood-coagulation factor XI, activated, blood-coagulation factor XIa, coagulation factor XI, coagulation factor XIa, factor XI, factor XIa, factor XIa catalytic domain, FXI, FXIa, fXIaCD, More, plasma thromboplastin antecedent, prolyl endopeptidase, protease factor XIa, PTA, recombinant human FXI370-607, rhFXI370-607
ECTree
3.4.21.27 coagulation factor XIaAdvanced search results
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results (Activating Compound
Activating Compound on EC 3.4.21.27 - coagulation factor XIa
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ACTIVATING COMPOUND 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
activated factor IX
autoactivation, cleavage of FXI at the Arg369-Ile370 bond. activated factor IX is part of a feedback loop that sustains thrombin generation through FIX activation to consolidate coagulation
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Protein disulfide isomerase
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reduction of the enzyme by protein disulfide isomerase enhances its cleavage activity
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activated factor XII
FXI activation proceeds through an intermediate with only one activated submit
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activated factor XII
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activated factor XII-mediated activation of FXI appears to play a central role in formation of pathologic thrombi in murine thrombosis models
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desmopressin
increase of both FXI activity (up to 31%) and antigen levels 60 min after infusion. Also contradictory results with a lack of rise of FXI levels after infusion
Factor XII
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FXI is activated by factor XII during ischemia reperfusion injury and within the growing thrombus according to the classical intrinsic pathway cascade
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thrombin
activated factor V is a cofactor for the activation of factor XI by thrombin. Depletion of factor V, or the addition of activated protein C, decreases the activation of the intrinsic pathway by thrombin in plasma. Factor XI binds to factor V with multiple binding sites. Addition of FVIIIa, kininogen, or protein S does not influence the formation of activated factor XI
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thrombin
FXI activation proceeds through an intermediate with only one activated submit
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thrombin
thrombin generated early in coagulation by the tissue factor pathway activates FXI creating a positive feedback loop that sustains coagulation following inactivation of the factor VIIa/tissue factor complex by tissue factor pathway inhibitor
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thrombin
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activates FXI. FXI activation by thrombin is enhanced by charged substances, such as dextran sulfate or heparin. Thrombin binds to the A1 domain of FXI, with residues Glu66, Lys83, and Gln84 forming part of the binding site. The dimer is required for optimal FXI activation by thrombin
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additional information
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activation of factor XI by thrombin and autoactivation to factor XIa
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additional information
FXI monomers are activated poorly, dimeric form is needed for activation. As FXI lacks a Gla domain, the dimeric structure may represent an alternative solution to the problem of tethering a prothrombotic molecule to a cellular surface in flowing blood in the vicinity of a wound
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additional information
platelets may play a role in FXI activation. FXI binding to platelets is not enhanced by kininogen
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additional information
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in blood challenged with low concentrations of tissue factor, factor XI can be activated independently of factor XII
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additional information
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antibody 14E11 exerts an inhibitory effect on fXI activation, but not fXIa activity
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