3.4.21.27: coagulation factor XIa
This is an abbreviated version!
For detailed information about coagulation factor XIa, go to the full flat file.
Word Map on EC 3.4.21.27
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3.4.21.27
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bleeding
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thrombin
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clot
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platelet
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thrombosis
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anticoagulant
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prothrombin
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kallikrein
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kininogen
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prekallikrein
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viii
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hemostasis
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venous
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fibrinogen
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antithrombin
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zymogen
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fibrinolysis
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procoagulant
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fibrin
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willebrand
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antithrombotic
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hemophilia
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thromboembolism
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plasmin
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ashkenazi
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fxiia
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hageman
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coagulopathy
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amidolytic
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diathesis
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haemostat
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thrombophilias
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leiden
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jewish
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antifibrinolytic
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kaolin
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proline-specific
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thrombin-activatable
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meningosepticum
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fletcher
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c1-inhibitor
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thromboelastometry
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drug development
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tenase
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medicine
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basque
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menorrhagia
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desmopressin
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tranexamic
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proline-containing
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tafi
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recalcified
- 3.4.21.27
- bleeding
- thrombin
- clot
- platelet
- thrombosis
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anticoagulant
- prothrombin
- kallikrein
- kininogen
- prekallikrein
- viii
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hemostasis
- venous
- fibrinogen
- antithrombin
- zymogen
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fibrinolysis
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procoagulant
- fibrin
- willebrand
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antithrombotic
- hemophilia
- thromboembolism
- plasmin
-
ashkenazi
- fxiia
-
hageman
- coagulopathy
-
amidolytic
- diathesis
-
haemostat
- thrombophilias
- leiden
-
jewish
-
antifibrinolytic
- kaolin
-
proline-specific
-
thrombin-activatable
- meningosepticum
-
fletcher
- c1-inhibitor
-
thromboelastometry
- drug development
-
tenase
- medicine
-
basque
- menorrhagia
- desmopressin
-
tranexamic
-
proline-containing
- tafi
-
recalcified
Reaction
Selective cleavage of Arg-/-Ala and Arg-/-Val bonds in factor IX to form factor IXa =
Synonyms
activated blood-coagulation factor XI, activated coagulation factor XIa, activated factor XI, activated factor XIa, activated FXI, activated plasma thromboplastin antecedent, blood coagulation factor XIa, blood-coagulation factor XI, activated, blood-coagulation factor XIa, coagulation factor XI, coagulation factor XIa, factor XI, factor XIa, factor XIa catalytic domain, FXI, FXIa, fXIaCD, More, plasma thromboplastin antecedent, prolyl endopeptidase, protease factor XIa, PTA, recombinant human FXI370-607, rhFXI370-607
ECTree
3.4.21.27 coagulation factor XIaAdvanced search results
results (
results (KM Value
KM Value on EC 3.4.21.27 - coagulation factor XIa
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KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.34
D-Ile-Pro-Arg-4-nitroanilide
recombinant wild-type enzyme, pH 7.5, 37°C
0.0003
factor IX
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wild type enzyme, in 50 mM Tris-HCl, 150 mM NaCl, 5 mM CaCl2, 0.5% (w/v) bovine serum albumin, pH 7.3, at 37°C
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0.205
L-pyroGlu-L-Pro-L-Arg-4-nitroanilide
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mutant enzyme K192R, in 50 mM Tris-HCl, 150 mM NaCl, 5 mM CaCl2, 0.5% (w/v) bovine serum albumin, pH 7.3, at 37°C
0.268
L-pyroGlu-L-Pro-L-Arg-4-nitroanilide
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mutant enzyme R3704A, in 50 mM Tris-HCl, 150 mM NaCl, 5 mM CaCl2, 0.5% (w/v) bovine serum albumin, pH 7.3, at 37°C
0.292
L-pyroGlu-L-Pro-L-Arg-4-nitroanilide
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mutant enzyme Y5901A, in 50 mM Tris-HCl, 150 mM NaCl, 5 mM CaCl2, 0.5% (w/v) bovine serum albumin, pH 7.3, at 37°C
0.315
L-pyroGlu-L-Pro-L-Arg-4-nitroanilide
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mutant enzyme K192E, in 50 mM Tris-HCl, 150 mM NaCl, 5 mM CaCl2, 0.5% (w/v) bovine serum albumin, pH 7.3, at 37°C
0.336
L-pyroGlu-L-Pro-L-Arg-4-nitroanilide
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mutant enzyme Y5901V, in 50 mM Tris-HCl, 150 mM NaCl, 5 mM CaCl2, 0.5% (w/v) bovine serum albumin, pH 7.3, at 37°C
0.339
L-pyroGlu-L-Pro-L-Arg-4-nitroanilide
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wild type enzyme, in 50 mM Tris-HCl, 150 mM NaCl, 5 mM CaCl2, 0.5% (w/v) bovine serum albumin, pH 7.3, at 37°C
0.383
L-pyroGlu-L-Pro-L-Arg-4-nitroanilide
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mutant enzyme E98D, in 50 mM Tris-HCl, 150 mM NaCl, 5 mM CaCl2, 0.5% (w/v) bovine serum albumin, pH 7.3, at 37°C
0.4
L-pyroGlu-L-Pro-L-Arg-4-nitroanilide
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mutant enzyme E98A, in 50 mM Tris-HCl, 150 mM NaCl, 5 mM CaCl2, 0.5% (w/v) bovine serum albumin, pH 7.3, at 37°C
0.525
L-pyroGlu-L-Pro-L-Arg-4-nitroanilide
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mutant enzyme E98V, in 50 mM Tris-HCl, 150 mM NaCl, 5 mM CaCl2, 0.5% (w/v) bovine serum albumin, pH 7.3, at 37°C
0.538
L-pyroGlu-L-Pro-L-Arg-4-nitroanilide
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mutant enzyme Y143A, in 50 mM Tris-HCl, 150 mM NaCl, 5 mM CaCl2, 0.5% (w/v) bovine serum albumin, pH 7.3, at 37°C
0.603
L-pyroGlu-L-Pro-L-Arg-4-nitroanilide
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mutant enzyme K192Q, in 50 mM Tris-HCl, 150 mM NaCl, 5 mM CaCl2, 0.5% (w/v) bovine serum albumin, pH 7.3, at 37°C
0.828
L-pyroGlu-L-Pro-L-Arg-4-nitroanilide
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mutant enzyme I151A, in 50 mM Tris-HCl, 150 mM NaCl, 5 mM CaCl2, 0.5% (w/v) bovine serum albumin, pH 7.3, at 37°C
0.852
L-pyroGlu-L-Pro-L-Arg-4-nitroanilide
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mutant enzyme K192A, in 50 mM Tris-HCl, 150 mM NaCl, 5 mM CaCl2, 0.5% (w/v) bovine serum albumin, pH 7.3, at 37°C
0.552
L-pyroglutamyl-L-prolyl-L-argininyl-p-nitroanilide
fXIa-catalytic domain-K170A/R171A/R173A mutant
0.655
L-pyroglutamyl-L-prolyl-L-argininyl-p-nitroanilide
fXIa-catalytic domain-K170A mutant
0.757
L-pyroglutamyl-L-prolyl-L-argininyl-p-nitroanilide
fXIa-catalytic domain-wild type
0.764
L-pyroglutamyl-L-prolyl-L-argininyl-p-nitroanilide
fXIa-catalytic domain-K179A mutant
0.81
L-pyroglutamyl-L-prolyl-L-argininyl-p-nitroanilide
fXIa-catalytic domain-R173A mutant
0.812
L-pyroglutamyl-L-prolyl-L-argininyl-p-nitroanilide
fXIa-catalytic domain-R171A mutant
0.829
L-pyroglutamyl-L-prolyl-L-argininyl-p-nitroanilide
fXIa-catalytic domain-K175A mutant
0.993
L-pyroglutamyl-L-prolyl-L-argininyl-p-nitroanilide
fXIa-R37Q mutant
0.26
pyroGlu-Pro-Arg-4-nitroanilide
recombinant wild-type enzyme, pH 7.5, 37°C
additional information
additional information
kinetics of recombinant wild-type and mutant enzymes, overview
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additional information
additional information
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kinetics of isolated subunits with each one active site, stoichiometry of FIX and FIXalphabeta binding to FXIa, overview
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