3.4.21.27: coagulation factor XIa

This is an abbreviated version!
For detailed information about coagulation factor XIa, go to the full flat file.

Word Map on EC 3.4.21.27

3.4.21.27

bleeding

thrombin

clot

platelet

thrombosis

anticoagulant

prothrombin

kallikrein

kininogen

prekallikrein

viii

hemostasis

venous

fibrinogen

antithrombin

zymogen

fibrinolysis

procoagulant

fibrin

willebrand

antithrombotic

hemophilia

thromboembolism

plasmin

ashkenazi

fxiia

hageman

coagulopathy

amidolytic

diathesis

haemostat

thrombophilias

leiden

jewish

antifibrinolytic

kaolin

proline-specific

thrombin-activatable

meningosepticum

fletcher

c1-inhibitor

thromboelastometry

drug development

tenase

medicine

basque

menorrhagia

desmopressin

tranexamic

proline-containing

tafi

recalcified

Reaction

Selective cleavage of Arg-/-Ala and Arg-/-Val bonds in factor IX to form factor IXa =

Synonyms

activated blood-coagulation factor XI, activated coagulation factor XIa, activated factor XI, activated factor XIa, activated FXI, activated plasma thromboplastin antecedent, blood coagulation factor XIa, blood-coagulation factor XI, activated, blood-coagulation factor XIa, coagulation factor XI, coagulation factor XIa, factor XI, factor XIa, factor XIa catalytic domain, FXI, FXIa, fXIaCD, More, plasma thromboplastin antecedent, prolyl endopeptidase, protease factor XIa, PTA, recombinant human FXI370-607, rhFXI370-607

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.27 coagulation factor XIa

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Results	in table
43	Activating Compound
50	AA Sequence
11	Application
1	CAS Registry Number
16	Cloned(Commentary)
1	Cofactor
8	Crystallization (Commentary)
4621	Disease/ Diagnostics
2	Expression
28	General Information
4	General Stability
47	IC50 Value
271	Inhibitors
2	kcat/KM [mM/s]
142	Ki Value [mM]
53	KM Value [mM]
8	Localization
9	Metals/Ions
25	Molecular Weight [Da]
44	Natural Substrates/ Products (Substrates)
84	Organism
123	PDB ID
6	pH Optimum
8	Posttranslational Modification
63	Protein Variants
19	Purification (Commentary)
1	Reaction
1	Reaction Type
84	Reference
47	Source Tissue
3	Specific Activity [micromol/min/mg]
1	Storage Stability
123	Substrates and Products (Substrate)
17	Subunits
149	Synonyms
7	Temperature Optimum [°C]
52	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.4.21.27 - coagulation factor XIa

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factor IX + H2O

2 entries

factor IX + H2O

activated factor IX + ?

7 entries

factor IX + H2O

factor IXa + ?

3 entries

factor V + H2O

activated factor V + ?

Homo sapiens

fXIa cleaves COOH-terminal to R306, possibly at the fXa/plasmin cleavage site R348

718042

factor VIII + H2O

activated factor VIII + ?

Homo sapiens

fXIa initially cleaves at R740 and R372 in the heavy chain and also makes several A3 cleavages most notably at R1652 and R1721

718042

pro-HGF + H2O

Homo sapiens

the enzyme may regulate processes that involve the HGF/c-Met pathway, such as tissue repair and angiogenesis

652338

prochemerin + H2O

chemerin + ?

Homo sapiens

753068

prochemerin chem163S + H2O

chemerin chem162R + chermerin chem158K

Homo sapiens

prochemerin is activated by a series of C-terminal proteolytic cleavages resulting in diverse chemerin forms with different levels of activity

753069

proteinase-activated receptor 1E + H2O

Rattus norvegicus

752439

tissue factor pathway inhibitor + H2O

Homo sapiens

the cleavage of the protein occurs between the Kunitz (K)1 and K2 domains (Lys86/Thr87) and at the active sites of the K2 (Arg107/Gly108) and K3 (Arg199/Ala200) domains

731538