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3.4.21.27: coagulation factor XIa

This is an abbreviated version!
For detailed information about coagulation factor XIa, go to the full flat file.

Word Map on EC 3.4.21.27

Reaction

Selective cleavage of Arg-/-Ala and Arg-/-Val bonds in factor IX to form factor IXa =

Synonyms

activated blood-coagulation factor XI, activated coagulation factor XIa, activated factor XI, activated factor XIa, activated FXI, activated plasma thromboplastin antecedent, blood coagulation factor XIa, blood-coagulation factor XI, activated, blood-coagulation factor XIa, coagulation factor XI, coagulation factor XIa, factor XI, factor XIa, factor XIa catalytic domain, FXI, FXIa, fXIaCD, More, plasma thromboplastin antecedent, prolyl endopeptidase, protease factor XIa, PTA, recombinant human FXI370-607, rhFXI370-607

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.27 coagulation factor XIa

Cloned

Cloned on EC 3.4.21.27 - coagulation factor XIa

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cDNAs in expression vector pJVCMV are used to transfect HEK-293 cells
expressed in baby hamster kidney cells
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expressed in HEK293 cells
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expressed in Pichia pastoris
expressed in Pichia pastoris strain X-33
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expression of mutant enzyme C362S/C482S in HEK-293 cells and secretion of recombinant protein to the medium
expression of the catalytic domain rhFXI370-60 of mutant S434A/T475A/C482S/K437A
expression of the peptide comprising 237 amino acids at the C-terminal end of FXI, peptide FXI/E361-V607, in Pichia pastoris strain X33
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expression of wild-type and mutant enzymes in HEK-293 cells
expression of wild-type and mutant enzymes in HEK-293 cells and secretion of recombinant protein to the medium
genetic location on chromosome 4q35, stable expression of wild-type and mutant enzymes in BHK-570 cells
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individual apple domains of FXI with a tPA-tag
recombinant human fXI is expressed in HEK-293 cells
stable expression of wild-type and mutant enzymes in HEK-293 cells
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