3.4.21.27: coagulation factor XIa

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For detailed information about coagulation factor XIa, go to the full flat file.

Word Map on EC 3.4.21.27

3.4.21.27

bleeding

thrombin

clot

platelet

thrombosis

anticoagulant

prothrombin

kallikrein

kininogen

prekallikrein

viii

hemostasis

venous

fibrinogen

antithrombin

zymogen

fibrinolysis

procoagulant

fibrin

willebrand

antithrombotic

hemophilia

thromboembolism

plasmin

ashkenazi

fxiia

hageman

coagulopathy

amidolytic

diathesis

haemostat

thrombophilias

leiden

jewish

antifibrinolytic

kaolin

proline-specific

thrombin-activatable

meningosepticum

fletcher

c1-inhibitor

thromboelastometry

drug development

tenase

medicine

basque

menorrhagia

desmopressin

tranexamic

proline-containing

tafi

recalcified

Reaction

Selective cleavage of Arg-/-Ala and Arg-/-Val bonds in factor IX to form factor IXa =

Synonyms

activated blood-coagulation factor XI, activated coagulation factor XIa, activated factor XI, activated factor XIa, activated FXI, activated plasma thromboplastin antecedent, blood coagulation factor XIa, blood-coagulation factor XI, activated, blood-coagulation factor XIa, coagulation factor XI, coagulation factor XIa, factor XI, factor XIa, factor XIa catalytic domain, FXI, FXIa, fXIaCD, More, plasma thromboplastin antecedent, prolyl endopeptidase, protease factor XIa, PTA, recombinant human FXI370-607, rhFXI370-607

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.27 coagulation factor XIa

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Results	in table
43	Activating Compound
50	AA Sequence
11	Application
1	CAS Registry Number
16	Cloned(Commentary)
1	Cofactor
8	Crystallization (Commentary)
4621	Disease/ Diagnostics
2	Expression
28	General Information
4	General Stability
47	IC50 Value
271	Inhibitors
2	kcat/KM [mM/s]
142	Ki Value [mM]
53	KM Value [mM]
8	Localization
9	Metals/Ions
25	Molecular Weight [Da]
44	Natural Substrates/ Products (Substrates)
84	Organism
123	PDB ID
6	pH Optimum
8	Posttranslational Modification
63	Protein Variants
19	Purification (Commentary)
1	Reaction
1	Reaction Type
84	Reference
47	Source Tissue
3	Specific Activity [micromol/min/mg]
1	Storage Stability
123	Substrates and Products (Substrate)
17	Subunits
149	Synonyms
7	Temperature Optimum [°C]
52	Turnover Number [1/s]

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hydrolysis of peptide bond