3.4.21.119: kallikrein 13
This is an abbreviated version!
For detailed information about kallikrein 13, go to the full flat file.
Word Map on EC 3.4.21.119
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3.4.21.119
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kallikreins
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prorenins
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submandibular
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medicine
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trypsin-like
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endoproteolytic
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diagnostics
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renin-angiotensin
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analysis
- 3.4.21.119
- kallikreins
- prorenins
-
submandibular
- medicine
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trypsin-like
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endoproteolytic
- diagnostics
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renin-angiotensin
- analysis
Reaction
Hydrolyses mouse Ren2 protein (a species of prorenin present in the submandibular gland) on the carboxy side of the arginine residue at the Lys-Arg-/- pair in the N-terminus, to yield mature renin =
Synonyms
GK-13, glandular kallikrein 13, glandular kallikrein K13, hK13, K13, kallikrein-related peptidase 13, KLK13, MGK-13, mK13, More, PRECE, prorenin converting enzyme, prorenin-converting enzyme, S01.306, tissue kallikrein
ECTree
3.4.21.119 kallikrein 13Advanced search results
results (
results (Substrates Products
Substrates Products on EC 3.4.21.119 - kallikrein 13
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
35 kDa pro-interleukin 1beta + H2O
17.5 kDa interleukin 1beta + 20 kDa interleukin 1beta
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cleavage of Leu113-Leu114 bond
-
-
?
Abz-MISLMKRPPGFSPFRSSRI-NH2 + H2O
Abz-MISLMKRPPGFSPFR + SSRI-NH2
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rapid cleavage
-
-
?
ABZ-Val-Arg-Phe-Arg-5-amino-2-nitrobenzoic acid + H2O
ABZ-Val-Arg-Phe-Arg + 5-amino-2-nitrobenzoic acid
kinetically preferred substrate
-
-
?
benzyloxycarbonyl-Arg-Val-Arg-Arg-4-methyl-coumaryl-7-amide + H2O
benzyloxycarbonyl-Arg-Val-Arg-Arg + 7-amino-4-methylcoumarin
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low activity
-
-
?
benzyloxycarbonyl-Gln-Arg-Arg-4-methyl-coumaryl-7-amide + H2O
benzyloxycarbonyl-Gln-Arg-Arg + 7-amino-4-methylcoumarin
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best substrate
-
-
?
benzyloxycarbonyl-Glu-Lys-Lys-4-methyl-coumaryl-7-amide + H2O
benzyloxycarbonyl-Glu-Lys-Lys + 7-amino-4-methylcoumarin
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low activity
-
-
?
benzyloxycarbonyl-Leu-Lys-Arg-4-methyl-coumaryl-7-amide + H2O
benzyloxycarbonyl-Leu-Lys-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
FSR-amido-4-methylcoumarin + H2O
FSR + 7-amino-4-methylcoumarin
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fluorogenic trypsin-like peptide substrate
-
-
?
histatin 3 + H2O
DSHAKRHHGYKRKFHEKHHSHRGYR + SNYLYDN
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i.e. DSHAKRHHGYKRKFHEKHHSHRGYRSNYLYDN, efficient substrate
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-
?
mouse prorenin Ren2 + H2O
renin + ?
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specific cleavage of Lys-Arg bond of mouse prorenin Ren2
-
-
?
myelin basic protein + H2O
?
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at least two cleavage sites are identified at YGGR-ASDYK and PRHR-DTGI
-
-
?
pyroglutamyl-Arg-Tyr-Lys-Arg-4-methyl-coumaryl-7-amide + H2O
pyroglutamyl-Arg-Tyr-Lys-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
VPR-amido-4-methylcoumarin + H2O
VPR + 7-amino-4-methylcoumarin
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fluorogenic trypsin-like peptide substrate
-
-
?
polypeptide + H2O
peptides
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cleavage site at paired basic amino acid residues
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?
polypeptide + H2O
peptides
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cleavage site at paired basic amino acid residues
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?
Prorenin + H2O
Renin + ?
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cleavage site at paired basic amino acid residues
-
?
Prorenin + H2O
Renin + ?
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cleavage site at paired basic amino acid residues
-
?
Prorenin + H2O
Renin + ?
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cleavage site at paired basic amino acid residues
-
?
Prorenin + H2O
Renin + ?
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cleavage site at paired basic amino acid residues
-
?
Prorenin + H2O
Renin + ?
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no cleavage of the peptide bond between Arg and Pro
-
?
Prorenin + H2O
Renin + ?
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specifically cleaves the peptide bond on the COOH-side of the Arg residue at the Lys-Arg pair of mouse Ren 2 prorenin, but does not cleave mouse Ren 1 and human prorenins
-
?
Prorenin + H2O
Renin + ?
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murine or human origin substrate from Xenopus oocytes expression system
-
?
Prorenin + H2O
Renin + ?
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inactive precursor
product is an active enzyme
?
Prorenin + H2O
Renin + ?
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inactive precursor
product is an active enzyme
?
Prorenin + H2O
Renin + ?
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inactive precursor
product is an active enzyme
?
additional information
?
-
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enzyme is involved in tissue remodeling and/or tumor invasion and metastasis
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-
?
additional information
?
-
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KLK13 does not hydrolyze Abz-KLRESKQ-EDDnp, Abz-KLRSEKQ-EDDnp, and AbzeELRSSKQ-EDDnp
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-
?
additional information
?
-
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the S2' subsite of KLK13 does not have restricted specificity but does present preference for the basic amino acid R and does not accepted negative charge
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-
?
additional information
?
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glycosylation near the processing site might prevent hydrolysis
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?
additional information
?
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no substrate: mouse prorenin Ren1, human prorenin
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-
?
