Inhibitors | Comment | Organism | Structure |
---|---|---|---|
antipain | - |
Mus musculus | |
benzamidine | - |
Mus musculus | |
leupeptin | - |
Mus musculus | |
additional information | little or no effect by the following protease inhibitors: PMSF, DFP, aprotinin, iodoacetamide, NEM, PCMBS, and E-64; no inhibition by EDTA and pepstatin A | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
polypeptide + H2O | Mus musculus | - |
peptides | - |
? | |
Prorenin + H2O | Mus musculus | inactive precursor | Renin + ? | product is an active enzyme | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
female and male ICR mice, Balb/c mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | low activity | Mus musculus | - |
additional information | no activity in liver, brain, heart, and pancreas | Mus musculus | - |
submandibular gland | highest activity | Mus musculus | - |
submandibular gland | enzyme regulation is parallel and similar to that of renin | Mus musculus | - |
submandibular gland | larger amounts in male than female mice | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
polypeptide + H2O | - |
Mus musculus | peptides | - |
? | |
polypeptide + H2O | cleavage site at paired basic amino acid residues | Mus musculus | peptides | - |
? | |
Prorenin + H2O | cleavage site at paired basic amino acid residues | Mus musculus | Renin + ? | - |
? | |
Prorenin + H2O | murine or human origin substrate from Xenopus oocytes expression system | Mus musculus | Renin + ? | - |
? | |
Prorenin + H2O | inactive precursor | Mus musculus | Renin + ? | product is an active enzyme | ? |
Synonyms | Comment | Organism |
---|---|---|
More | enzyme is neither trypsin-like nor kallikrein | Mus musculus |
prorenin-converting enzyme | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | 8.5 | - |
Mus musculus |