3.4.21.119: kallikrein 13

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For detailed information about kallikrein 13, go to the full flat file.

Reaction

Hydrolyses mouse Ren2 protein (a species of prorenin present in the submandibular gland) on the carboxy side of the arginine residue at the Lys-Arg-/- pair in the N-terminus, to yield mature renin =

Synonyms

GK-13, glandular kallikrein 13, glandular kallikrein K13, hK13, K13, kallikrein-related peptidase 13, KLK13, MGK-13, mK13, More, PRECE, prorenin converting enzyme, prorenin-converting enzyme, S01.306, tissue kallikrein

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.119 kallikrein 13

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Results	in table
5	Activating Compound
2	AA Sequence
11	Application
2	CAS Registry Number
6	Cloned(Commentary)
1	Crystallization (Commentary)
98	Disease/ Diagnostics
3	Expression
4	General Information
1	General Stability
2	IC50 Value
12	Inhibitors
8	kcat/KM [mM/s]
8	KM Value [mM]
6	Localization
1	Metals/Ions
7	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
23	Organism
5	pH Optimum
1	pI Value
2	Posttranslational Modification
1	Protein Variants
5	Purification (Commentary)
7	Reaction
1	Reaction Type
23	Reference
79	Source Tissue
1	Specific Activity [micromol/min/mg]
49	Substrates and Products (Substrate)
7	Subunits
28	Synonyms
3	Temperature Optimum [°C]
8	Turnover Number [1/s]

Expression

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Expression on EC 3.4.21.119 - kallikrein 13

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

kallikrein-related peptidase 13 is downregulated in oral squamous cell carcinoma cell lines

Homo sapiens

Q9UKR3

732498

the kallikrein-related peptidase 13 gene is substantially up-regulated after exposure of gastric cancer cells to antineoplastic agents, epirubicin, oxaliplatin, or methotrexate

Homo sapiens

Q9UKR3

732961

the KLK13 gene is dysregulated in several carcinomas, and its expression levels seem to be associated with disease prognosis

Homo sapiens

Q9UKR3

732966