3.4.21.119: kallikrein 13
This is an abbreviated version!
For detailed information about kallikrein 13, go to the full flat file.
Word Map on EC 3.4.21.119
-
3.4.21.119
-
kallikreins
-
prorenins
-
submandibular
-
medicine
-
trypsin-like
-
endoproteolytic
-
diagnostics
-
renin-angiotensin
-
analysis
- 3.4.21.119
- kallikreins
- prorenins
-
submandibular
- medicine
-
trypsin-like
-
endoproteolytic
- diagnostics
-
renin-angiotensin
- analysis
Reaction
Hydrolyses mouse Ren2 protein (a species of prorenin present in the submandibular gland) on the carboxy side of the arginine residue at the Lys-Arg-/- pair in the N-terminus, to yield mature renin =
Synonyms
GK-13, glandular kallikrein 13, glandular kallikrein K13, hK13, K13, kallikrein-related peptidase 13, KLK13, MGK-13, mK13, More, PRECE, prorenin converting enzyme, prorenin-converting enzyme, S01.306, tissue kallikrein
ECTree
Advanced search results
Application
Application on EC 3.4.21.119 - kallikrein 13
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
analysis
substrate substrate ABZ-Val-Arg-Phe-Arg-Ser-Thr-Gln-Tyr(3-NO2)-NH2 is suitable for determination of KLK13 activity and is successfully converted into an activity-based probe by the incorporation of a chloromethylketone warhead and biotin bait. The modified subvsrtae is applicable in complex biological samples
diagnostics
medicine
gene KLK13 mRNA expression constitutes a biomarker for the prediction of overall survival in nonsmall cell lung cancer and that its quantitative assessment in tumor tissues can aid in treatment decision making. Kaplan-Meier survival analyses demonstrate that patients with KLK13-positive tumors survive significantly longer than those with KLK13-negative ones
diagnostics
loss of the enzyme is a potential biomarker for early detection of lymph node metastasis in oral squamous cell carcinoma cell lines
diagnostics
the enzyme has clinical importance as a favorable prognostic biomarker for gastric cancer patients' survival
gene may be involved in the pathogenesis and/or progression of breast cancer and may find applicability as cancer biomarker
medicine
-
most salivary gland tumors show high levels of enzyme expression. Pleomorphic adenoma shows less staining than normal tissue, adenoid cystic carcinomas, polymorphous low grade adenocarcinomas and adenocarcinomas not otherwise specified stain significantly more than normal salivary gland tissue
medicine
-
patients with ovarian carcinoma, women with enzyme-positive tumors most often have early stage disease, no residual tumor after surgery and optimal debulking success. Patients with enzyme-positive tumors have a significantly longer progression-free survival and overall survival. Use of enzyme as biomarker for ovarian carcinoma
medicine
-
treatment of ovarian cancer cell lines secreting enzyme with an enzyme neutralizing antibody results in less migration of cells
medicine
-
a multiparametric panel of kallikrein markers for lung cancer diagnosis with relatively good accuracy is provided
medicine
-
although marginally significant, patients with high KLK13 expression at the mRNA or protein level have lower overall survival